Sterility of assembled heart-lung pump beyond 48 hours

Chorak, Janice; Leader, Isabel; Patterson, Maria; Kumar, Ashir

doi:10.1016/0196-6553(90)90232-h

Cited by 5 publications

(7 citation statements)

References 3 publications

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“…Our results are concordant with the results of previous studies on this subject [6][7][8][9][10]. Our results are concordant with the results of previous studies on this subject [6][7][8][9][10].…”

Section: Discussionsupporting

confidence: 93%

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Safety of Heart-Lung Machines during Prolonged Standby

et al. 2003

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Background: Coronary artery bypass surgery is increasingly performed without an extra-corporeal circuit. A heart-lung machine (HLM) is kept on standby for safety reasons, but rarely used. The tubes of the machines are currently discarded after every operation. Costs and waste would be avoided if HLMs could stay on standby for longer periods of time. We therefore investigated the sterility of intra-tube fluid over time. Materials and Methods: Four machines were tested. The tube system was fixed and filled with priming solution. Samples of intra-tube fluid and fluid from the fluid bags were taken after 0, 12, 24, 36, 48 and 72 h. Microbiological cultures were performed by direct inoculation and membrane filtration and incubated up to 14 days. Endotoxin levels were also determined. Results: Bacteria were grown from two samples only and were considered as contaminants. Endotoxin concentrations never exceeded acceptable levels. Conclusion: To keep HLMs on standby for 72 h is probably safe. The prolonged use of HLMs will contribute to cost and waste reduction in open heart surgery.

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Section: Discussionsupporting

confidence: 93%

“…Most other studies have tested the sterility of CPB circuits under dry conditions [6,7] or shortly after priming [8,9]. with circulating intra-tube fluid and within the operation area, where the HLMs are kept on standby while off-pump heart surgery is being performed.…”

Section: Discussionmentioning

confidence: 99%

Safety of Heart-Lung Machines during Prolonged Standby

et al. 2003

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“…Many institutions have developed local policies and procedures for maintaining preassembled and preprimed ECMO circuits to minimize the time to successful ECMO initiation. In 1990, Chorak et al 8 reported a nonprimed dry assembled circuit could maintain sterility for a period of 48 to 60 hours. Young et al 9 conducted a study in 1997 to evaluate 12 ECMO circuits (6 dry circuits and 6 wet circuits), for a period of 7 days for potential microbial contamination.…”

Section: Discussionmentioning

confidence: 99%

Sterility Duration of Preprimed Extracorporeal Membrane Oxygenation Circuits

Tan¹,

Evangelista²,

Carella³

et al. 2018

The Journal of Pediatric Pharmacology and Therapeutics

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“…In 1990, Chorack and colleagues 11 demonstrated that an ECC circuit, assembled without priming, could maintain sterility for 48-60 hours. Omishak et al 13 raised the threshold to 2.5 days using complete ECMO circuits (n=17) primed (but not circulating) with three litres of solution.…”

Section: Discussionmentioning

confidence: 99%

“…Many institutions have adopted the policy of having an ECC assembled in advance, especially during the weekend; 11,12 nevertheless, it may happen that the circuit is not used. The official regulations in the management of sterile devices require their immediate use after opening the sterile packaging.…”

Section: Introductionmentioning

confidence: 99%

Wet-priming extracorporeal membrane oxygenation device maintains sterility for up to 35 days of follow-up

et al. 2012

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In emergency cases, rapid extracorporeal membrane oxygenation (ECMO) device initialization is able to drastically reduce the incidence of patient morbidity and/or mortality. Pre-assembled and ready-to-use ECMO circuits might save up to 30-60 critical minutes in patient management. Six ECMO circuits (Oxygenator D905 EOS with REVOLUTION™ pump and Sorin PTS) were assembled in the operating room in standard conditions and then placed at 37°C for 35 days in order to evaluate possible contamination and ingrowth of micro-organisms. Every 7 days after ECMO circuit assembly and wet-priming, samples of priming fluid were analyzed to verify the presence/absence of possible common contaminants (Enterobacteriaceae, Staphylococcus aureus and fungi). Moreover, two supplementary circuits, used as positive controls, were deliberately inoculated with a known concentration of a Escherichia coli strain and prime samplings carried out at different time-points to determine bacterial growth rate. Sterility was maintained in the ECMO circuits for up to 35 days.

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Sterility of assembled heart-lung pump beyond 48 hours

Cited by 5 publications

References 3 publications

Safety of Heart-Lung Machines during Prolonged Standby

Safety of Heart-Lung Machines during Prolonged Standby

Sterility Duration of Preprimed Extracorporeal Membrane Oxygenation Circuits

Wet-priming extracorporeal membrane oxygenation device maintains sterility for up to 35 days of follow-up

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