Sterilization of Polymeric Implants: Challenges and Opportunities

Herczeg, Chloe K.; Song, Jie

doi:10.1021/acsabm.2c00793

Cited by 9 publications

(11 citation statements)

References 98 publications

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“…Generally, the two primary classes of polymers are categorized according to how long they last under physiological conditions based on their biodegradability and stability in in vivo environments . Biostable polymers, such as polytetrafluoroethylene (PTFE), poly(methyl methacrylate) (PMMA), ultrahigh molecular weight polyethene (UHMWPE), and polyether ether ketone (PEEK), have exceptional stability when implanted in the body . While the biodegradable polymers progressively degrade into biocompatible compounds in the biological milieu of the host body, these substances include polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PLC), and polylactic- co -glycolic acid (PLGA).…”

Section: Polymer-based Hip Implantsmentioning

confidence: 99%

“…PTFE’s mechanical strength is insufficient compared to other biostable polymers. Table − depicts the general mechanical properties of PTFE. Typically, adding foreign materials is the primary tool for enhancing the mechanical properties of these polymers.…”

Section: Polymer-based Hip Implantsmentioning

confidence: 99%

“…201 Biostable polymers, such as polytetrafluoroethylene (PTFE), poly(methyl methacrylate) (PMMA), ultrahigh molecular weight polyethene (UHMWPE), and polyether ether ketone (PEEK), have exceptional stability when implanted in the body. 202 While the biodegradable polymers progressively degrade into biocompatible compounds in the biological milieu of the host body, these substances include polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PLC), and polylacticco-glycolic acid (PLGA). As a result, biostable polymers such as PTFE, UHMWPE, and PEEK are a feasible choice for hip operations due to their nondegradable nature 203 and are often utilized for different hip repair applications.…”

Section: Polymer-based Hip Implantsmentioning

confidence: 99%

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Comprehensive Review on Biomaterials and Their Inherent Behaviors for Hip Repair Applications

Sathishkumar,

Paulraj,

Chakraborti

et al. 2023

ACS Appl. Bio Mater.

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Developing biomaterials for hip prostheses is challenging and requires dedicated attention from researchers. Hip replacement is an inevitable and remarkable orthopedic therapy for enhancing the quality of patient life for those who have arthritis as well as trauma. Generally, five types of hip replacement procedures are successfully performed in the current medical market: total hip replacements, hip resurfacing, hemiarthroplasty, bipolar, and dual mobility systems. The average life span of artificial hip joints is about 15 years, and several studies have been conducted over the last 60 years to improve the performance and thereby increase the lifespan of artificial hip joints. Present-day prosthetic hip joints are linked to the wide availability of biomaterials. Metals, ceramics, and polymers are some of the most promising types of biomaterials; nevertheless, each biomaterial has advantages and disadvantages. Metals and ceramics fail in most applications owing to stress shielding and the emission of wear debris; ongoing research is being carried out to find a remedy to these unfavorable responses. Recent research found that polymers and composites based on polymers are significant alternative materials for artificial joints. With growing research and several biomaterials, recent reviews lag in effectively addressing hip implant materials' individual mechanical, tribological, and physiological behaviors. This Review comprehensively investigates the historical evolution of artificial hip replacement procedures and related biomaterials' mechanical, tribological, and biological characteristics. In addition, the most recent advances are also discussed to stimulate and guide future researchers as they seek more effective methods and synthesis of innovative biomaterials for hip arthroplasty application.

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Section: Polymer-based Hip Implantsmentioning

confidence: 99%

Section: Polymer-based Hip Implantsmentioning

confidence: 99%

Section: Polymer-based Hip Implantsmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive Review on Biomaterials and Their Inherent Behaviors for Hip Repair Applications

Sathishkumar,

Paulraj,

Chakraborti

et al. 2023

ACS Appl. Bio Mater.

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“…One critical point of the translation of therapeutic implants to the clinic is showing feasibility of sterilization. 27 Ionizing radiation in the form of gamma irradiation is one of the most common sterilization techniques for medical devices, including UHMWPE implants. The structure and longevity of many materials comprised in implants, especially polymeric components, can be significantly affected by irradiation.…”

Section: Introductionmentioning

confidence: 99%

“…One critical point of the translation of therapeutic implants to the clinic is showing feasibility of sterilization . Ionizing radiation in the form of gamma irradiation is one of the most common sterilization techniques for medical devices, including UHMWPE implants.…”

Section: Introductionmentioning

confidence: 99%

Irradiation Behavior of Analgesic and Nonsteroidal Anti-Inflammatory Drug-Loaded UHMWPE for Joint Replacement

Lekkala,

Inverardi,

Grindy

et al. 2024

Biomacromolecules

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Local delivery of pain medication can be a beneficial strategy to address pain management after joint replacement, as it can decrease systemic opioid usage, leading to less side and long-term effects. In this study, we used ultrahigh molecular weight polyethylene (UHMWPE), commonly employed as a bearing material for joint implants, to deliver a wide set of analgesics and the nonsteroidal anti-inflammatory drug tolfenamic acid. We blended the drugs with UHMWPE and processed the blend by compression molding and sterilization by low-dose gamma irradiation. We studied the chemical stability of the eluted drugs, drug elution, tensile properties, and wear resistance of the polymer blends before and after sterilization. The incorporation of bupivacaine hydrochloride and tolfenamic acid in UHMWPE resulted in either single-or dual-drug loaded materials that can be sterilized by gamma irradiation. These compositions were found to be promising for the development of clinically relevant drug-eluting implants for joint replacement.

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