Sternal osteomyelitis caused by Aspergillus fumigatus in a patient with previously treated Hodgkin's disease

Allen, David A.; Ng, S; Beaton, K.; Taussig, David

doi:10.1136/jcp.55.8.616

Cited by 20 publications

(8 citation statements)

References 7 publications

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“…In endemic areas Mycobacterium tuberculosis infection may occur both as a primary event [11] and disseminated bacille CalmetteGuérin infection postvaccination may involve the sternum [12]. Rarer causative organisms include Aspergillus fumigatus in the immunocompromised patient [13] and Candida albicans seen in debilitated patients poststernotomy [14]. Pseudomonas species have been isolated from IV drug users [1].…”

Section: Discussionmentioning

confidence: 98%

Primary sternal osteomyelitis: a case series and review of the literature

Upadhyaya¹,

Keil²,

Thonell³

et al. 2005

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 98%

Primary sternal osteomyelitis: a case series and review of the literature

Upadhyaya¹,

Keil²,

Thonell³

et al. 2005

Journal of Pediatric Surgery

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“…Hematogenous infection in adults has been associated with i.v drug abuse, sickle-cell anemia, and blunt thoracic trauma; but iatrogenic infections have also been described, following bone-marrow aspiration, resuscita- [10,[18][19][20]. Several antibiotic regimens have been published, but surgical intervention with debridement of infected tissue and even sternectomy have also been recommended [10].…”

Section: Discussionmentioning

confidence: 99%

Sternal osteomyelitis complicating percutaneous coronary artery stenting

Bonatti

Berger

Waltner-Romen

et al. 2004

Wien Klin Wochenschr

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Hematogenous sternal osteomyelitis is a rare infection that has been associated with i.v drug abuse and blunt thoracic trauma, but iatrogenic infections have also been described following resuscitation and in conjunction with hemodialysis catheters. Staphylococcus aureus is the most common causative organism. Stenting is the preferred treatment for isolated stenosis of the coronary artery and is associated with a low complication rate and high patency rate. Such intravascular procedures are rarely complicated by infections. A 72-year-old man developed hematogenous sternal osteomyelitis following coronary artery stenting. Radiological diagnosis was made using CT scan and MRI, and blood cultures and aspiration fluid from the infected soft tissue were positive for S. aureus. Initial therapy consisted of i.v. second-generation cephalosporin followed by oral cephalexin and later linezolid. Prolonged antibiotic therapy without surgical intervention was successful in controlling this rare complication. The patient was well at the one-year follow up, with patent stent and no signs for recurrent osteomyelitis. Although transcutaneous stenting is a widely accepted strategy for treating stenosed arteries, this case highlights the possibility of hazardous infectious complications associated with such procedures.

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“…Mycobacterium tuberculosis in endemic areas [12], Aspergillus fumigatus in immunocompromised patients [13] and Candida albicans [14] have also been reported to cause sternal osteomyelitis. In our case report apart of Streptococcus pneumoniae , Enterococcus Species was also isolated, an organism that has never been reported before as an infecting cause of primary sternal osteomyelitis in the international literature.…”

Section: Discussionmentioning

confidence: 99%

Primary sternal osteomyelitis in a 40 days old infant: a case report and review of the literature

Pettas

Apostolopoulos

Flieger

et al. 2009

Cases J

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IntroductionPrimary sternal osteomyelitis is extremely rare in children and only very few cases have been reported in the international literature.Case presentationA 40 days old Caucasian infant was referred to our clinic with a 4 days history of fever and malaise, accompanying a painful swelling of four days duration involving the lower end of the sternum. Examination revealed a 2 cm swelling which was fixed to the underlying bone. A full blood count, erythrocyte sedimentation rate, and C-reactive protein were measured and x-rays (Anterior and Lateral views) and Ultrasound was performed. Blood cultures were also taken. The patient was commenced empirically to Vancomycin and Cefotaxime intravenously.The values of White Blood Cell (16,720), erythrocyte sedimentation rate (132 mm) and C-reactive protein (108 mg/dl) were elevated, the X-rays showed bone destruction and dislocation of the 3rd sternal nuclei and in the U/S performed appeared a soft tissue mass measuring 2,37/1,02 cm related to the periosteum. Surgical debridement was then performed and swab cultures were taken intraoperatively. The infant grew Streptococcus Pneumoniae and Enterococcus Species. The infant was discharged after 25 days from the hospital. He gradually improved over a period of 2 months, became pain free and repeated x-rays showed significant bone resolution.ConclusionPrimary osteomyelitis in infants is a very rare condition that usually resolves with antibiotic therapy and surgical debridement.

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Sternal osteomyelitis caused by Aspergillus fumigatus in a patient with previously treated Hodgkin's disease

Cited by 20 publications

References 7 publications

Primary sternal osteomyelitis: a case series and review of the literature

Primary sternal osteomyelitis: a case series and review of the literature

Sternal osteomyelitis complicating percutaneous coronary artery stenting

Primary sternal osteomyelitis in a 40 days old infant: a case report and review of the literature

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