Steroid-binding proteins and testosterone level in the badger plasma during the annual cycle

Audy, M.C.; Martin, Bernard; Charron, G.; Bonnin, M.

doi:10.1016/0016-6480(82)90022-3

Cited by 17 publications

(3 citation statements)

References 15 publications

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“…Steroid hormone-binding proteins which resemble the CBG and SHBG reported in human plasma (Daughaday, 1958;Mercier-Bodard, Alfsen & Baulieu, 1970) have also been found in other eutherian mam¬ mals and non-mammalian vertebrates (Seal & Doe, 1965Westphal, 1967Westphal, , 1971Westphal, , 1986Idler, 1972;Corvol & Bardin, 1973;Sernia, 1980;Audy, Martin, Charron & Bonnin, 1982).…”

Section: Introductionmentioning

confidence: 89%

Seasonal changes in plasma androgens, glucocorticoids and glucocorticoid-binding proteins in the marsupial sugar glider Petaurus breviceps

Bradley

Stoddart²

1992

Journal of Endocrinology

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An investigation spanning two breeding seasons was carried out to examine endocrine changes associated with reproduction in a wild population of the marsupial sugar glider Petaurus breviceps, a small arboreal gliding possum. Using techniques of equilibrium dialysis and polyacrylamide gel electrophoresis at steady-state conditions, a high-affinity, low-capacity glucocorticoid-binding protein was demonstrated in the plasma of Petaurus breviceps. Equilibrium dialysis at 36 degrees C using cortisol gave a high-affinity binding constant of 95 +/- 5.2 litres/mumol for a presumed corticosteroid-binding globulin (CBG) while the binding constant for the cortisol-albumin interaction was 3.5 +/- 0.4 litres/mmol. There was no difference between the sexes in the affinity of binding of cortisol to CBG; however, the cortisol-binding capacity underwent seasonal variation in both sexes. Progesterone was bound strongly to the presumed CBG while neither oestradiol nor aldosterone appeared to be bound with high affinity to P. breviceps plasma. In the males, peaks in the plasma concentration of testosterone coincided with the July-September breeding season in both years. A significant inverse relationship was shown to exist between the plasma testosterone concentration and the CBG-binding capacity. In both sexes an increase occurred in the plasma concentration of free cortisol during the first breeding season, a pattern which was not repeated in the subsequent breeding season, possibly due to a lower population density in that year.

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Section: Introductionmentioning

confidence: 89%

Seasonal changes in plasma androgens, glucocorticoids and glucocorticoid-binding proteins in the marsupial sugar glider Petaurus breviceps

Bradley

Stoddart²

1992

Journal of Endocrinology

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“…Concentrations of SBP exhibit marked fluctuations during the important reproductive periods of (1) puberty (Danzo & Eller, 1975;Horst et ai, 1977;Blank et ai, 1978;Berger et ai, 1980Gaidano et ai, 1980Gustafson & Damassa, 1984;Lee et al, 1985; Belgorosky & Rivarola, 1986Maruyama et al, 1987, (2) pregnancy (Rivarola et al, 1968;Anderson et ai, 1976;Heyns, 1977Schiller et al, 1978Uriel et ai, 1981), and (3) renewal of seasonal activity (Maurel et al, 1980;Audy et al, 1982;Saboureau et al, 1982;Gustafson & Damassa, 1985). The significance of these fluctuations remains to be clarified.…”

Section: Introductionmentioning

confidence: 96%

Post-natal patterns of plasma androgen-binding activity in Djungarian (Phodopus sungorus) and golden (Mesocricetus auratus) hamsters

Gustafson¹,

Damassa²,

Pratt³

et al. 1989

Reproduction

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The binding of sex steroids to plasma proteins was examined in post-natal Djungarian and golden hamsters. With dihydrotestosterone or testosterone as ligands, steady-state polyacrylamide gel electrophoresis revealed 2 androgen binding components in the plasma of young Djungarian hamsters of both sexes. The fast-moving component exhibited a low affinity and high capacity for androgens and corresponded to albumin in stained gels. In contrast, the slow moving component was a \g=b\-globulin with high affinity (Ka = 109 m \ m=-\ 1) and low capacity for androgens, and was identified as a specific sex steroid-binding protein (SBP; also SHBG). This SBP did not bind oestrogens or corticosteroids and was electrophoretically distinct from corticosteroid-binding globulin (CBG). In addition, this protein did not appear to be of testicular origin because it was present in immature females and in immature males that had been castrated for 8 days. Plasma concentrations of SBP in males as measured by a diethylaminoethyl-cellulose binding assay were low at birth, became significantly elevated shortly thereafter when plasma androgen values were also elevated, and subsequently fell to low levels during puberty. These changes follow the same general pattern that has been described for other mammals, including humans, during this period of reproductive development. Although the significance of elevated SBP concentrations during prepuberty has yet to be determined, it appears that the increased concentrations of high-affinity androgen binding in the plasma of Djungarian hamsters plays a role in the asynchronous pubertal development of the testes and accessory organs which occurs in this species. The post-natal SBP pattern in females was similar to that observed in males. Plasma SBP levels were low or undetectable in adults of both sexes. As previously described for adult golden hamsters, the plasma of post-natal male and female golden hamsters lacked a specific SBP: androgen binding in this species is apparently limited to albumin and CBG.

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“…Plasma SBP activity was shown to be at a maximum during hibernation (Saboureau, Laurent & Boissin, 1982), at a time when T4 levels reached a minimum (Saboureau & Boissin, 1978). In the male badger, seasonal changes in plasma androgen-binding capacity were difficult to characterize (Audy, Martin, Charron & Bonnin, 1982), but appeared to be low in November, December, February, March and April and showed peaks of activity in January, May-August and October.…”

Section: Discussionmentioning

confidence: 97%

Control of sex steroid-binding protein (SBP) in the male little brown bat: relationship of plasma thyroxine levels to the induction of plasma SBP in immature males

Kwiecinski¹,

Damassa²,

Gustafson³

1986

Journal of Endocrinology

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The seasonally reproductive male little brown bat (Myotis lucifugus lucifugus) exhibits marked increases in plasma concentrations of sex steroid-binding protein (SBP) in the spring following arousal from hibernation. In this species an increase in SBP levels is induced prematurely in male bats aroused during the first half of hibernation and housed under long photoperiods; however, this rise is inhibited in bats housed under short photoperiods. In order to investigate the physiological role of the thyroid gland in the regulation of plasma SBP activity, plasma total thyroxine (T4) and SBP concentrations were determined in immature male little brown bats prematurely aroused from the first half of hibernation and maintained on either a short or long photoperiod. For this purpose a radioimmunoassay for the measurement of total T4 in bat plasma was established and validated. The results showed that immature male little brown bats aroused prematurely from hibernation and housed under a long spring-like photoperiod exhibited marked increases in plasma T4 and SBP concentrations, while animals housed under a short photoperiod showed only marginal increases in SBP, and plasma T4 remained undetectable. These results suggest that the thyroid gland, through the action of T4, may normally play an important role in the control of the post-arousal rise in plasma SBP concentrations in the little brown bat.

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Steroid-binding proteins and testosterone level in the badger plasma during the annual cycle

Cited by 17 publications

References 15 publications

Seasonal changes in plasma androgens, glucocorticoids and glucocorticoid-binding proteins in the marsupial sugar glider Petaurus breviceps

Seasonal changes in plasma androgens, glucocorticoids and glucocorticoid-binding proteins in the marsupial sugar glider Petaurus breviceps

Post-natal patterns of plasma androgen-binding activity in Djungarian (Phodopus sungorus) and golden (Mesocricetus auratus) hamsters

Control of sex steroid-binding protein (SBP) in the male little brown bat: relationship of plasma thyroxine levels to the induction of plasma SBP in immature males

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