Steroid cell tumors of the ovary: clinical, ultrasonic, and MRI diagnosis—a case report

Wang, Peng-Hui; Chao, Hsiang‐Tai; Lee, Rheun‐Chuan; Lai, CL; Lee, Wen-Ling; Kwok, Ching-Fai; Yuan, Chiou‐Chung; Ng, Heung-Tat

doi:10.1016/s0720-048x(96)01133-3

Cited by 72 publications

(69 citation statements)

References 12 publications

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“…However the most noticieable features are due to hormonal activity and virilising tendencies of the tumor. 16 On the other hand, these tumors may produce little or no androgenic activity and could, sometime show the evidence of estrogenic effect. 8,17 These tumors may be difficult to identify on radiological imaging, in part because they are isoechoic to the uterus on ultrasonography and isoattenuating on CT. MRI with phased array coils, or colour Doppler imaging, can possibly detect smaller tumours than more conventional imaging methods.…”

Section: Discussionmentioning

confidence: 99%

“…8,17 These tumors may be difficult to identify on radiological imaging, in part because they are isoechoic to the uterus on ultrasonography and isoattenuating on CT. MRI with phased array coils, or colour Doppler imaging, can possibly detect smaller tumours than more conventional imaging methods. 16,18,19 Unfortunately clinical presentation and sonographic appreance cannot predict which mass is malignant. 20 It has been suggested that a simple clinical assessment and a single serum testosterone measurement may be sufficient to differentiate between benign and malignant virilising tumors in women presenting with hirsutism and androgenic features.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian stromal tumor with minor sex-cord element with virilizing menifestations: a rare case report

Sharma

Vij

Mahajan

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ovarian stromal tumor with minor sex-cord element with virilizing menifestations: a rare case report

Sharma

Vij

Mahajan

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…Patients who do not have postmenopausal or fertility requirement, staged surgery should be conducted in those who have total abdominal hysterectomy and bilateral salpingo-ooforectomy and malignant criteria. Approximately 25-43% of steroid cell tumors are malignant (13,14) . In malignant tumors, postoperative adjuvant chemotherapy is required.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Steroid Cell Tumor: Report Of Four Cases

Tohma¹,

Koç²,

Ozgul³

et al. 2013

J Turk Soc Obstet Gynecol

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“…These tumours can be a source of testosterone and other steroids, hence can cause hirsutism and virilisation in a female adults and precocious puberty in children. [1][2][3][4] Approximately one-third of the steroid cell tumours have been reported to be malignant. 1 Since Virilizing tumours of the ovary account for only 0.1% of all ovarian tumours, not much has been studied on the modalities of treatment for the same.…”

Section: Introductionmentioning

confidence: 99%

Masculinising Ovarian Steroid Cell Tumor in a 51 Year Old Indian Female: A Case Report

C.S¹,

B.M²,

Tauheed³

et al. 2013

jemds

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Virilizing or masculinizing features in a female can be an alarm for the doctor and a source of embarrassment for the patient. These features appear as a result of hyperandrogenism, the source being ovary or adrenal gland. Here is a case of Virilizing ovarian tumour in a 51 year old diabetic female. This patient presented with a 14 year history of appearance of hair all over the body with loss of scalp hair. She also had complaints of pain in lower abdomen with excessive micturition for 3 months. Examination showed hirsutism and features of virilisation. Suprapubic mass was present on abdominal examination. Per vaginal exam revealed a soft mass? Ovarian. Radiological tests showed features suggestive of ovarian malignancy with possible uterine involvement and mild ascites. Most routine hematological investigations were normal. Total testosterone was grossly elevated (>1500 ng/dl); CA-125 was also raised (103.7 U/ml). FSH & LH values were low, TSH was normal while estradiol& progesterone were raised. Urine microscopy had features of urinary tract infection; hence treatment was started for the same. Patient underwent panhysterectomy. Histopathological studies confirmed steroid cell left ovarian tumour (T1aN0Mx), which was the source of virility in the patient. Patient improved dramatically after the surgery with reversal of androgenic features (partial).key words: steroid cell tumor, hirsutism, and panhysterectomy. INTRODUCTION:Steroid cell tumors are tumors composed entirely or predominantly of cells resembling steroid hormone secreting cells. They are classified under sex cord-stromal tumors which account for approximately 8% of all ovarian tumors. These tumours can be a source of testosterone and other steroids, hence can cause hirsutism and virilisation in a female adults and precocious puberty in children. [1][2][3][4] Approximately one-third of the steroid cell tumours have been reported to be malignant. 1 Since Virilizing tumours of the ovary account for only 0.1% of all ovarian tumours, not much has been studied on the modalities of treatment for the same. Although surgery has been the mainstay, a recent report showed that gonadotropin releasing hormone agonist was effective in treating steroid cell tumors. [5][6] Here, we present a case of a 51year old lady who presented with hirsutism, virilisation of 14 year duration and was found to have steroid cell tumour of the left ovary measuring 12x12x9 cm. She showed drastic reversal of symptoms following panhysterectomy and was declared free of tumour.

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Steroid cell tumors of the ovary: clinical, ultrasonic, and MRI diagnosis—a case report

Cited by 72 publications

References 12 publications

Ovarian stromal tumor with minor sex-cord element with virilizing menifestations: a rare case report

Ovarian stromal tumor with minor sex-cord element with virilizing menifestations: a rare case report

Ovarian Steroid Cell Tumor: Report Of Four Cases

Masculinising Ovarian Steroid Cell Tumor in a 51 Year Old Indian Female: A Case Report

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