Steroid cell tumour- NOS of the ovary in a young female

Abstract

The patient, 22 year old, married since 3 years presented with history of primary infertility and excessive hair growth with change in the voice. She had history of oligomenorrhea and noted decrease in the size of the breast. There was no other significant past medical or surgical history. On general examination, vital parameters were within normal limits. Hirsutism was present. Genital examination revealed the presence of Clitoromegaly. Laboratory investigations revealed S. Androstenedione levels of more than 10ng/ml (Range: 0.3-2 ng/ml) and the level of S. Testosterone was 6.79 ng/ml (Range: 0.15-0.7 ng/ml). S. FSH level was 6.8 miu/ml (Range: 2.3-18.5 miu/ ml), S. LH level was 7.95 miu/ml (Range: 0.4-105 miu/ml) while S. ACTH level was 21.2 pg/ml (Range: 5-27 pg/ml). MRI Pelvis revealed right ovary measuring 4.6 X 4.4 X 3.4 cm which showed a focal lesion in the ovarian stroma. The left ovary was normal. Patient underwent right salpingooophorectomy with left ovarian drilling. Pranav Pramod Patwardhan*, Annapurna Chandrashekhar Taware and Pragati Aditya SatheDepartment of Pathology, Seth G S Medical College, Mumbai, India ABSTRACTSex cord stromal cell tumours constitute 5-8 % of all ovarian neoplasms. Steroid cell tumours are a type of sex cord stromal cell tumours. The name "Steroid cell" stands for the morphology and the functionality of these tumours. Steroid cell tumours-Not otherwise specified constitute about 56% of all steroid cell tumours and presents more commonly with androgenic manifestations in third to fourth decade.We present a case, 22 year old, who presented with virilizing symptoms. MRI was suggestive of an right ovarian mass for which right salpingo-oophorectomy was done. Histopathology revealed features classical of Steroid cell tumour-Not otherwise specified. We present the case for a relatively younger age at presentation and the classical histomorphology.

Recurrent ovarian steroid cell tumour not otherwise specified: A case report

“…It is rare, accounting for about 0.1% of all ovarian tumors. 1 In a study conducted by Hayes et al 2 , the mean age of presentation for steroid cell tumor is 43 years, in which if presented in patients aged 51 years or older, the possibility of the tumor to be malignant is higher. Otherwise, there are no other specific risk factors associated with steroid cell tumor illustrated in literatures.…”

“…These are defined as an ovarian neoplasm compound made up entirely of cells that resemble steroid-secreting cells but without Reinke crystals. 1 Steroid cell tumor not otherwise specified (NOS) is the most common variety of steroid cell tumors, besides other less common tumors, namely Leydig cell tumor and stromal luteoma. Androgenic manifestation was observed in 41% of patients, whereas hyperestrogenic and hypercortisolism features were reported in some cases.…”

“…These are defined as an ovarian neoplasm compound made up entirely of cells that resemble steroid‐secreting cells but without Reinke crystals. 1 …”

“…It is an uncommon neoplasm, accounting for only 0.16% of all ovarian tumors. These are defined as an ovarian neoplasm compound made up entirely of cells that resemble steroid‐secreting cells but without Reinke crystals 1 …”

“…These are defined as an ovarian neoplasm compound made up entirely of cells that resemble steroid-secreting cells but without Reinke crystals. 1 Steroid cell tumor not otherwise specified (NOS) is the most common variety of steroid cell tumors, besides other…”