Steroid Hormone Receptors During Brain Development

Kato, Junzo

doi:10.1016/b978-0-08-024940-7.50028-7

Development of Responsiveness to Steroid Hormones 1980

DOI: 10.1016/b978-0-08-024940-7.50028-7

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Steroid Hormone Receptors During Brain Development

Junzo Kato

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1987

1989

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Cited by 2 publications

References 135 publications

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Daily Rhythms of Serum Luteinizing Hormone in the Immature Hamster are Estradiol-Dependent1

Donham

Posern

Stetson

1987

Biology of Reproduction

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In the female Syrian hamster (Mesocricetus auratus), daily rhythms of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) begin several weeks before regular vaginal estrous cycles are initiated. These rhythms, which appear rather abruptly at about 16 days of age, are dependent on the presence of the ovaries. The experiments described here were intended to determine the nature of the ovarian information required for the initiation and maintenance of the daily LH surge. This surge characterizes the daily cycle of LH and occurs each afternoon at about 1700 h in the intact animal between 2 and 5 weeks of age. Females were ovariectomized at 14 or 15 days of age and implanted with constant-release Silastic capsules of estradiol (E) or progesterone (P). Blood samples were collected at 21 days of age at 1400 or 1700 b, and the serum was assayed for LH, P, and E. While ovariectomy abolished the afternoon surge of serum LH that was observed in sham-operated controls, implantation of E effectively replaced the ovaries. Implantation of P was without effect on LH levels; when P plus E was implanted, the effect was similar to that of E alone. These results suggest that ovaries of the 2-week-old hamster secrete estrogen necessary for the initiation of cyclical LH release.

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Daily Rhythms of Serum Luteinizing Hormone in the Immature Hamster are Estradiol-Dependent1

Donham

Posern

Stetson

1987

Biology of Reproduction

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Estrogen Receptor Content of Regions of the Hypothalamus and Pituitary of the Gilt From Four to Twenty-Eight Weeks of Age

Evans¹,

Christopherson²,

Aherne³

1989

Can. J. Anim. Sci.

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Estradiol-17β receptors (E2R) in 100 000 × g supernatant fractions from the hypothalamus and pituitary were determined for groups of five gilts, slaughtered at 4-wk intervals from 4 to 28 wk of age. Tissue samples were separated into the anterior hypothalamus (AH), the central hypothalamus (CH), posterior hypothalamus (PH), anterior pituitary (AP) and posterior pituitary (PP). After saturation binding assays were conducted, E2R concentrations were determined by Scatchard analysis. When expressed on a fmol mg−1 protein basis there was no increase in receptor concentration with age (P > 0.05); however, AP had higher concentrations of receptors than the AH, CH or PH (10.6 ± 1.4 vs. 6.5 ± 0.9, 6.7 ± 0.7 and 6.2 ± 0.6, P < 0.01). Posterior pituitary receptor levels remained low during maturation of the gilt with affinity constant (Ka) values similar to that obtained for the AP. Affinity constant values were found not to change with age; however, AP values were greater than that of the hypothalamus samples (55.2 ± 2.7 vs. 4.8 ± 0.2, × 108M−1). On a total tissue basis AH and CH had significant increases in receptor content from 4 to 28 wk (41.4 to 138.2 and 31.6 to 163.4 fmol, P < 0.05). It was also determined that the soluble protein content per gram wet tissue decreased with age in all regions of the hypothalamus and therefore may mask increases in receptor numbers. Keywords: Estradiol, receptor, gilt, hypothalamus, pituitary, swine

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Steroid Hormone Receptors During Brain Development

Cited by 2 publications

References 135 publications

Daily Rhythms of Serum Luteinizing Hormone in the Immature Hamster are Estradiol-Dependent1

Daily Rhythms of Serum Luteinizing Hormone in the Immature Hamster are Estradiol-Dependent1

Estrogen Receptor Content of Regions of the Hypothalamus and Pituitary of the Gilt From Four to Twenty-Eight Weeks of Age

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