Steroid hormone receptors in cancer development: A target for cancer therapeutics

Ahmad, Nihal; Kumar, Raj

doi:10.1016/j.canlet.2010.09.008

Cited by 113 publications

(84 citation statements)

References 94 publications

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“…What is relevant, the same hormone could induce different effects in various species through non-classical pathway, or the same result could be achieved by different steroids. Controversies regarding membrane pathway could stem just from this diversity and heterogeneity [8]. Both, visualization of levels on which nuclear and membrane fractions of the receptors could reciprocally work, and recognition of every cell and tissue where membrane receptors are expressed, might enable a new, innovative look at processes which, although known, remain elusive [79].…”

Section: Discussionmentioning

confidence: 99%

“…the influence of estrogens on neurons, testosterone on macrophages and prostate cells, as well as the activity of glucocorticosteroids, aldosterone, triiodothyronine, thyroxine, retinoids and calcitriol, have been described [4 -7]. Membrane receptors seem to be specific variants of nuclear receptors and are formed through alternative splicing or post-translational modification [8].…”

Section: Introductionmentioning

confidence: 99%

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New Insight into Progesterone-dependent Signalization

Kociszewska¹,

Czekaj²

2017

PHARMSCI

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Background:Various effects of steroid hormone activity cannot easily be explained by the action of classical nuclear receptors and genomic signal transduction pathways. These activities are manifested principally as rapid processes, lasting from seconds to minutes, resulting in changes in ion transduction, calcium intracellular concentration, and level of the second messengers, which cannot be realized through the genomic pathway. Hence, it has been proposed that other kinds of mediators should be involved in steroid-induced processes, namely receptors located on the cell surface. The search for their chemical nature and role is of utmost importance. Current state of knowledge confirms their relation to GPCRs. Moreover, it seems that almost every nuclear receptor specific for steroid hormone family has its membrane-bound equivalent. Objective:In this review, we summarize current state of knowledge about nuclear and membrane receptors for progesterone, and describe their potential functions alone, as well as in cooperation with other receptors. Conclusion:In the light of common expression, both in species and organs, membrane receptors could play a role that is at least comparable to nuclear receptors. Further exploration of membrane receptor-dependent signaling pathways could give a new insight in the treatment of many endocrine and oncological pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Insight into Progesterone-dependent Signalization

Kociszewska¹,

Czekaj²

2017

PHARMSCI

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“…Hormone signaling can play important roles in the development and survival of various cancers, most notably those related to the sex organs, including breast and prostate cancer (70,71). The androgen receptor (AR) is amplified in more than 40% of cases of metastatic prostate cancer (70), and androgen signaling is thought to be a strong driver of prostate cancer growth and metastasis.…”

Section: Imaging Androgen Receptor Signalingmentioning

confidence: 99%

Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine

et al. 2017

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Comprehensive molecular analysis of individual tumors provides great potential for personalized cancer therapy. However, the presence of a particular genetic alteration is often insufficient to predict therapeutic efficacy. Drugs with distinct mechanisms of action can affect the biology of tumors in specific and unique ways. Therefore, assays that can measure drug-induced perturbations of defined functional tumor properties can be highly complementary to genomic analysis. PET provides the capacity to noninvasively measure the dynamics of various tumor biologic processes in vivo. Here, we review the underlying biochemical and biologic basis for a variety of PET tracers and how they may be used to better optimize cancer therapy.

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“…44 Steroid hormones and their nuclear receptors are highly correlated with cancers and have been investigated as anticancer targets. 45 It will be interesting to examine if mammalian Nrf2 regulates the productions of as well as the responses to steroid hormones, and if the interaction between Nrf2 and steroid hormone signaling contributes to carcinogenesis.…”

Section: Flymentioning

confidence: 99%

Multiple roles of Nrf2-Keap1 signaling

Huai

2013

Fly

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X enobiotic and oxidative responses protect cells from external and internal toxicities. Nrf2 and Keap1 are central factors that mediate these responses, and are closely related with many human diseases. In a recent study, we revealed novel developmental function and regulatory mechanism of Nrf2 and Keap1 by investigating their Drosophila homolog CncC and dKeap1. We found that CncC and dKeap1 control metamorphosis through regulations of ecdysone biosynthetic genes and ecdysone response genes in different tissues. CncC and dKeap1 cooperatively activate these developmental genes, in contrast to their conserved antagonizing effect to xenobiotic response transcription. In addition, interactions between CncC and Ras signaling in metamorphosis and in transcriptional regulation were established. Here I discuss the implications that place these classic xenobiotic response factors into a broader network that potentially control development and oncogenesis using mechanisms other than those mediating xenobiotic response.

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Steroid hormone receptors in cancer development: A target for cancer therapeutics

Cited by 113 publications

References 94 publications

New Insight into Progesterone-dependent Signalization

New Insight into Progesterone-dependent Signalization

Harnessing Preclinical Molecular Imaging to Inform Advances in Personalized Cancer Medicine

Multiple roles of Nrf2-Keap1 signaling

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