Steroid hormone receptors in human colon cancers

Alford, T. C.; ‐M, Hoan‐My; Geelhoed, Glenn W.; Tsangaris, N. T.; Lippman, Marc E.

doi:10.1002/1097-0142(197903)43:3<980::aid-cncr2820430329>3.0.co;2-r

Cited by 139 publications

(25 citation statements)

References 20 publications

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“…It has been shown, at least in mammary carcinomas, to represent an independent prognostic factor [2]. Besides these "typical" sex-hormone-dependent cancers, SSHR have been found in a whole variety of other cancer types, such as hepatocellular carcinomas [21], colon cancer [1] and malignant melanomas [27,9]. Therefore, it is no surprise that the occurence of SHRs has also been described in squamous cell carcinoma cell lines [17].…”

Section: Discussionmentioning

confidence: 99%

Analysis of sex-hormone-receptor expression in laryngeal carcinoma

Hagedorn¹,

Nerlich

2002

European Archives of Oto-Rhino-Laryngology

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There are significant differences in how laryngeal cancer affects the two genders, with cases occuring predominantly in males. This has been speculated to result from the different susceptibilities of the tumor cells to steroid sex hormones. Since the sex hormone action is mediated by specific cellular receptors, several previous studies have analyzed the presence of these sex-hormone receptors. However, the data on the receptor status for androgen, estrogen and progesterone receptors in laryngeal carcinomas are controversial. Since some authors have suggested antiandrogen or antiestrogen therapy as an adjuvant treatment for laryngeal carcinoma, we performed a comprehensive study using immunomorphological and biochemical techniques on both in-vivo and in-vitro tumor cells in order to clarify whether major sex-hormone receptors are present or not. We performed an immunohistochemical analysis on 13 patients with laryngeal carcinomas, 8 males and 5 females, using monoclonal antibodies against androgen, estrogen and progesterone receptors. In addition, the presence of estrogen and progesterone receptors was tested biochemically using an enzyme immune assay (EIA). Furthermore, we analyzed immunohistochemically the expression of the hormone receptors in five keratinocyte cell lines originating from laryngeal carcinomas. In all of our tumor samples, as well as in the five tumor cell lines tested, we did not detect any specific immunohistochemical staining for androgen, estrogen and progesterone receptors in the laryngeal carcinoma cells when compared to the positive controls of breast and prostate cancer samples. Similarly, the biochemical analysis did not demonstrate any significant amount of receptor protein in the analyzed cases. In conclusion, the absence of male and female sex-hormone receptors strongly argues against laryngeal carcinomas being sex-hormone-dependent tumors. Therefore, we do not see any rational indication to use a specific antiandrogen or antiestrogen therapy for the adjuvant treatment of laryngeal carcinomas.

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Section: Discussionmentioning

confidence: 99%

Analysis of sex-hormone-receptor expression in laryngeal carcinoma

Hagedorn¹,

Nerlich

2002

European Archives of Oto-Rhino-Laryngology

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“…Moreover, previous reports have indicated the existence of estrogen and progesterone receptors in colorectal cancers. 10,11 Yakushiji et al reported that estrogen and estrogen receptor in tumor cells is involved in tumor progression and ovarian metastases, which can easily occur in the premenopausal state when ovarian function is very active. 12 In our patient, a rapid increase in tumor size was observed within only 2 months, during which time irregular vaginal bleeding continued.…”

Section: Discussionmentioning

confidence: 99%

Manifestation of Bilateral Huge Ovarian Metastases from Colon Cancer Immediately After the Initial Operation: Report of a Case

et al. 2002

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This report describes the case of a 34-year-old premenopausal woman in whom bilateral huge ovarian metastases were found immediately after initial surgery for sigmoid colon cancer. Both ovaries had been intact at the time of sigmoidectomy, but 2 months later, she complained of persistent vaginal bleeding, and large bilateral metastases were detected in both ovaries. Oophorectomy with intraperitoneal chemotherapy proved ineffective and the patient died 3 months later, after a second operation, from peritoneal dissemination. This case report serves to demonstrate the importance of searching for synchronous or nonsynchronous metastases to the ovaries after surgery for colon cancer in young women. Consideration should also be given to the feasibility of performing prophylactic oophorectomy or administering intensive chemotherapy in association with colon resections for carcinoma for premenopausal women because of the ineffectiveness of these modalities as treatment for metastatic disease.

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“…ER and PR expression have been associated with a more favorable prognosis and increased survival in breast cancer [7][8][9]. In addition, an active estrogen-signaling pathway attenuated p53 apoptotic responses leading to tumor formation [10].…”

Section: Introductionmentioning

confidence: 99%

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Barrera

Shroyer

Said

et al. 2007

Head and Neck Pathol

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Objectives The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer. Study Design ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens. Methods Formalin-fixed paraffin-embedded tissues from 47 ACC specimens and 47 samples of normal salivary gland tissue were evaluated histochemically for the presence of ER, PR and p53. Immunoreactivity was scored using a 0 to +3 scale in which staining was either (0) negative, (+1) spotty, (+2) weakly positive, or (+3) strongly positive. Results ER was expressed in 8 of 47 tumors while PR was expressed in 4 of 47 tumors. p53 aberrations were demonstrated in 26 of 47 tumors. Tumors showed varying degrees of immunopositivity ranging from 0 to +3. Conclusions These studies suggest that p53 aberrations may be involved in ACC tumor progression and that ER and PR may play a role in ACC development.

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Steroid hormone receptors in human colon cancers

Cited by 139 publications

References 20 publications

Analysis of sex-hormone-receptor expression in laryngeal carcinoma

Analysis of sex-hormone-receptor expression in laryngeal carcinoma

Manifestation of Bilateral Huge Ovarian Metastases from Colon Cancer Immediately After the Initial Operation: Report of a Case

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

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