Steroid hormones and pregnancy

Noyola-Martínez, Nancy; Halhali, Ali; Barrera, David

doi:10.1080/09513590.2018.1564742

Cited by 96 publications

(56 citation statements)

References 81 publications

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“…Moreover, hCG plays an essential role in the differentiation of the trophoblast, by an autocrine mechanism, and promotes further differentiation of cytotrophoblasts into syncytiotrophoblasts [ 85 ]. P4 allows maintenance of myometrial quiescence and E2 regulates utero-placental blood flow and plays a role in contraction of the myometrium during childbirth [ 86 ]. Therefore, disturbances of these hormones, especially in early pregnancy, can affect the course of pregnancy and its outcome.…”

Section: Discussionmentioning

confidence: 99%

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

et al. 2020

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The human placenta is at the interface between maternal and fetal circulations, and is crucial for fetal development. The nanoparticles of cerium dioxide (CeO2 NPs) from air pollution are an unevaluated risk during pregnancy. Assessing the consequences of placenta exposure to CeO2 NPs could contribute to a better understanding of NPs’ effect on the development and functions of the placenta and pregnancy outcome. We used primary villous cytotrophoblasts purified from term human placenta, with a wide range of CeO2 NPs concentrations (0.1–101 μg/cm2) and exposure time (24–72 h), to assess trophoblast uptake, toxicity and impact on trophoblast differentiation and endocrine function. We have shown the capacity of both cytotrophoblasts and syncytiotrophoblasts to internalize CeO2 NPs. CeO2 NPs affected trophoblast metabolic activity in a dose and time dependency, induced caspase activation and a LDH release in the absence of oxidative stress. CeO2 NPs decreased the fusion capacity of cytotrophoblasts to form a syncytiotrophoblast and disturbed secretion of the pregnancy hormones hCG, hPL, PlGF, P4 and E2, in accordance with NPs concentration. This is the first study on the impact of CeO2 NPs using human primary trophoblasts that decrypts their toxicity and impact on placental formation and functions.

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Section: Discussionmentioning

confidence: 99%

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

et al. 2020

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“…Cholesterol is the precursor of progesterone [41], which is the key steroid for the maintenance of pregnancy. Furthermore, progesterone modulates the maternal immune system favoring the tolerance toward fetal allograft [42]. Besides, it has been shown that progesterone increases the anti-inflammatory cytokine production in maternal T lymphocytes [43].…”

Section: Discussionmentioning

confidence: 99%

Detection of Vaginal Metabolite Changes in Premature Rupture of Membrane Patients in Third Trimester Pregnancy: a Prospective Cohort Study

Liu

Chen

et al. 2020

Reprod. Sci.

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Premature rupture of membranes (PROM) is usually associated with pregnant and neonatal complications. Most of the PROM cases are caused by ascending asymptomatic genital infection. In China, PROM (15.3%) is more common than spontaneous preterm labor (7.3%) and leads to more adverse pregnancy outcomes. Here, we designed a prospective cohort study to measure the metabolomics changes in vaginal swab samples and explored their potential contribution to PROM. A total of 260 differentially expressed metabolites were identified and further analyzed. In the PROM group, N-acetyl-d-galactosamine and sucrose were downregulated (P = 0.0025, P = 0.0195, respectively), both of which are the upstream metabolites of the glycolysis pathway. Furthermore, estriol 3-sulfate 16-glucuronide (P = 0.0154) and 2-methoxy-17beta-estradiol 3-glucosiduronic acid (P = 0.004), two final metabolites in steroid hormone biosynthesis, were both downregulated in the PROM group. Finally, we found two catechin metabolites (epigallocatechin-7-glucuronide, P = 0.0009; 4′-methyl-epigallocatechin-7-glucuronide, P = 0.01) as well as DL-citrulline (P = 0.0393) were also significantly downregulated in the PROM group compared with the healthy control (HC) group, which are related to important antioxidant and anti-inflammatory activities in the human body. Altogether, metabolite changes in glycolysis, steroid hormone biosynthesis, and antioxidant/anti-inflammatory pathways may contribute to (or be a consequence of) vaginal dysbiosis and PROM. Metabolite pathway analysis is a new and promising approach to further investigate the mechanism of PROM and help prevent its unfavorable pregnant outcomes at a functional level. Trial registration number: ChiCTR2000034721

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“…Indeed, during pregnancy, cell-mediated immunity is depressed to avoid fetal rejection ( Figure 3 ), whereas humoral immune responses, promoting the transfer of maternal antibodies to the fetus, are increased ( 215 – 218 ). The primary hormones supporting pregnancy are estrogens and progesterone ( 219 ) that increase throughout gestation and alter the immune responses both systemically and at the maternal-fetal interface ( 215 ). This bidirectional interaction between hormones and the immune system contributes first to pregnancy outcomes, e.g., full-term or preterm birth, and spontaneous abortion, and secondly, to a lowered relapse rate in women with MS ( Figure 3 ).…”

Section: Biology Of Sex Differences In Multiple Sclerosismentioning

confidence: 99%

SeXX Matters in Multiple Sclerosis

2020

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Multiple sclerosis (MS) is the most common chronic inflammatory and neurodegenerative disease of the central nervous system (CNS). An interesting feature that this debilitating disease shares with many other inflammatory disorders is that susceptibility is higher in females than in males, with the risk of MS being three times higher in women compared to men. Nonetheless, while men have a decreased risk of developing MS, many studies suggest that males have a worse clinical outcome. MS exhibits an apparent sexual dimorphism in both the immune response and the pathophysiology of the CNS damage, ultimately affecting disease susceptibility and progression differently. Overall, women are predisposed to higher rates of inflammatory relapses than men, but men are more likely to manifest signs of disease progression and worse CNS damage. The observed sexual dimorphism in MS may be due to sex hormones and sex chromosomes, acting in parallel or combination. In this review, we outline current knowledge on the sexual dimorphism in MS and discuss the interplay of sex chromosomes, sex hormones, and the immune system in driving MS disease susceptibility and progression.

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Steroid hormones and pregnancy

Cited by 96 publications

References 81 publications

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta

Detection of Vaginal Metabolite Changes in Premature Rupture of Membrane Patients in Third Trimester Pregnancy: a Prospective Cohort Study

SeXX Matters in Multiple Sclerosis

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