Steroid-induced Glaucoma: An Avoidable Irreversible Blindness

Pandav, SS; Kaur, Savleen; Kaushik, Sushmita; Phulke, Sonia

doi:10.5005/jp-journals-10028-1226

Cited by 198 publications

(102 citation statements)

References 49 publications

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“…Similar to other corticosteroid treatments [ 22 ], increases in IOP may occur with the dexamethasone intracanalicular insert [ 6 ]. Monitoring IOP is recommended during treatment with the dexamethasone intracanalicular insert, and caution is advised if the dexamethasone intracanalicular insert is used in patients with glaucoma [ 6 ].…”

Section: Tolerability Of the Dexamethasone Insertmentioning

confidence: 99%

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Dexamethasone Intracanalicular Insert: A Review in Treating Post-Surgical Ocular Pain and Inflammation

Lee

Blair

2020

Drugs

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Dextenza ® , an intracanalicular insert that is placed into the lower punctal opening of the eye, gradually releases dexamethasone for up to 30 days to alleviate pain and inflammation associated with ophthalmic surgery. A significantly higher proportion of patients treated with the dexamethasone intracanalicular insert than with the placebo insert had no pain at day 8 (co-primary endpoint, 7 days post-operation) across three pivotal phase III trials, and the inflammation co-primary endpoint (absence of anterior chamber cells) at day 14 (13 days post-operation) was met in two of three trials. Overall, the dexamethasone intracanalicular insert was effective and generally well tolerated for the treatment of post-surgical ocular pain and inflammation following cataract surgery. As low patient adherence is an issue for topical ophthalmic anti-inflammatory medications, the convenience (ease of insertion, single application with no patient input and typically no removal required) of the dexamethasone intracanalicular insert makes it a promising emerging option for the treatment of ocular inflammation and pain following ophthalmic surgery.

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Section: Tolerability Of the Dexamethasone Insertmentioning

confidence: 99%

“…4 ). Although elevated IOP is associated with use of topical corticosteroids [ 22 ], increases in IOP AEs with the dexamethasone intracanalicular insert were limited to day 2 (i.e. 1 day after surgery).…”

Section: Current Status Of the Dexamethasone Intracanalicular Insert mentioning

confidence: 99%

Dexamethasone Intracanalicular Insert: A Review in Treating Post-Surgical Ocular Pain and Inflammation

Lee

Blair

2020

Drugs

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“…Several studies have reported congenital renal anomalies as the most common renal diagnosis. [2,5,6,19,20] In this research, the congenital renal abnormalities were the second most frequent renal disease. Congenital, hereditary, and genetic renal disease can be attributed to the high prevalence of parental consanguinity in the Jordanian community although there is a declining trend in consanguinity: "The level of consanguinity decreased from 57% in 1990 to 35% in 2012, according to the Jordan Population and Family Health Surveys."…”

Section: Discussionmentioning

confidence: 66%

Spectrum and contributing factors of renal diseases among Jordanian children

Alkadomi

Shawish

Saleh

et al. 2019

CNS

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Renal diseases are a significant cause of morbidity and mortality in children. They can affect children in various ways: they vary from completely treatable without long-lasting consequences to severe disorders such as chronic kidney disease. The causes of renal disease may differ from one country to another. Understanding the spectrum and identifying the contributing factors of renal diseases in a specific country promote early diagnosis, facilitate treatment, and prevent complications such as renal failure and end-stage kidney disease. This study was conducted to establish the spectrum and contributing factors to renal diseases among Jordanian children receiving health care in a tertiary hospital in Amman, Jordan (Prince Hamza Hospital). A convenience sample of 129 children diagnosed with renal diseases, treated and followed in our nephrology clinic, were interviewed during 2015 to 2017. A kidney-disease patient questionnaire was used to interview the children or their caregivers. The study revealed that the most common renal disease among the participants was urinary tract infection (UTI, 35.7%), followed by congenital diseases (34.1%), then chronic renal failure (CRF, 11.6%). There were several contributing factors of renal disease among the studied children, such as malnutrition, poverty, high rate of consanguinity, delayed diagnosis, and geographical location.

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“…It is known that topical, periocular, and even systemic or inhaled administration of steroids can cause OH [91]. The significant elevation of the IOP can occur in a matter of hours or up to 1 day after steroid use.…”

Section: Models Of Ocular Hypertension (Oh)mentioning

confidence: 99%

Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans—A Review of the Literature

2019

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Glaucoma is a common complex disease that leads to irreversible blindness worldwide. Even though preclinical studies showed that lowering intraocular pressure (IOP) could prevent retinal ganglion cells loss, clinical evidence suggests that lessening IOP does not prevent glaucoma progression in all patients. Glaucoma is also becoming more prevalent in the elderly population, showing that age is a recognized major risk factor. Indeed, recent findings suggest that age-related tissue alterations contribute to the development of glaucoma and have encouraged exploration for new treatment approaches. In this review, we provide information on the most frequently used experimental models of glaucoma and describe their advantages and limitations. Additionally, we describe diverse animal models of glaucoma that can be potentially used in translational medicine and aid an efficient shift to the clinic. Experimental animal models have helped to understand the mechanisms of formation and evacuation of aqueous humor, and the maintenance of homeostasis of intra-ocular pressure. However, the transfer of pre-clinical results obtained from animal studies into clinical trials may be difficult since the type of study does not only depend on the type of therapy to be performed, but also on a series of factors observed both in the experimental period and the period of transfer to clinical application. Conclusions: Knowing the exact characteristics of each glaucoma experimental model could help to diminish inconveniences related to the process of the translation of results into clinical application in humans.

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Steroid-induced Glaucoma: An Avoidable Irreversible Blindness

Cited by 198 publications

References 49 publications

Dexamethasone Intracanalicular Insert: A Review in Treating Post-Surgical Ocular Pain and Inflammation

Dexamethasone Intracanalicular Insert: A Review in Treating Post-Surgical Ocular Pain and Inflammation

Spectrum and contributing factors of renal diseases among Jordanian children

Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans—A Review of the Literature

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