Steroid receptor RNA activator bi-faceted genetic system: Heads or Tails?

Cooper, Charlton; Vincett, Daniel; Yan, Yongping; Hamedani, Mohammad K.; Myal, Yvonne; Leygue, Etienne

doi:10.1016/j.biochi.2011.07.002

Cited by 53 publications

(50 citation statements)

References 43 publications

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“…The SRA proteins also bind their own RNAs, and SRA/SRA coding transcripts also act in muscle myogenic differentiation as cofactors of myogenic differentiation (MyoD), 112 are associated with nuclear receptor-dependent cancers, and are a component of gene insulator complexes. 110 SRA also is present in a 600-kb linkage disequilibrium block associated with human dilated cardiomyopathy in 3 independent populations. 113 Knockdown of the zebrafish SRA homolog caused myocardial contractile dysfunction predominantly in ventricular heart chambers, 113 perhaps consistent with the role of nuclear receptors in cardiomyocyte maturation and function.…”

Section: Sra and Human Dilated Cardiomyopathymentioning

confidence: 99%

Long Noncoding RNAs in Cardiac Development and Pathophysiology

Schönrock

Harvey

Mattick

2012

Circulation Research

216

167

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Heart function requires sophisticated regulatory networks to orchestrate organ development, physiological responses, and environmental adaptation. Until recently, it was thought that these regulatory networks are composed solely of protein-mediated transcriptional control and signaling systems; consequently, it was thought that cardiac disease involves perturbation of these systems. However, it is becoming evident that RNA, long considered to function primarily as the platform for protein production, may in fact play a major role in most, if not all, aspects of gene regulation, especially the epigenetic processes that underpin organogenesis. These include not only wellvalidated classes of regulatory RNAs, such as microRNAs, but also tens of thousands of long noncoding RNAs that are differentially expressed across the entire genome of humans and other animals. Here, we review this emerging landscape, summarizing what is known about their functions and their role in cardiac biology, and provide a toolkit to assist in exploring this previously hidden layer of gene regulation that may underpin heart adaptation and complex heart diseases. (Circ Res. 2012;111:1349-1362.)

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Section: Sra and Human Dilated Cardiomyopathymentioning

confidence: 99%

Long Noncoding RNAs in Cardiac Development and Pathophysiology

Schönrock

Harvey

Mattick

2012

Circulation Research

216

167

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“…This subgroup seemed to be defined also by a high expression of a potential modulator of ERb activity, called steroid receptor RNA activator protein (Yan et al, 2013). This ER co-regulator is encoded by a gene that in its own right is also bi-faceted, as alternative splicing of its transcripts results in a functional non-coding RNA and/or a protein able to modulate transcription (Cooper et al 2011).…”

Section: Clinical Correlation Studies Supporting the Bi-faceted Role mentioning

confidence: 99%

A bi-faceted role of estrogen receptor β in breast cancer

Leygue¹,

Murphy²

2013

Endocrine-Related Cancer

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Despite over 15 years of research, the exact role, if any, played by estrogen receptor b (ERb) in human breast cancer remains elusive. A large body of data both in vitro and in vivo supports its role as an antiproliferative, pro-apoptotic factor especially when co-expressed with ERa. However, there is a smaller body of data associating ERb with growth and survival in breast cancer. In clinical studies and most often in cell culture studies, the pro-growth and prosurvival activity of ERb occurs in ERa-negative breast cancer tissue and cells. This bi-faceted role of ERb is discussed in this review.

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“…109,110 SNPs in the SRA1 gene are associated with human dilated cardiomyopathy and SRA depletion results in contractile dysfunction in the ventricles of zebrafish, suggesting that this gene is important in cardiac development and function. 111 Noncoding SRA transcripts display tissue-specific expression patterns and are abundant in the liver, skeletal muscle, and heart.…”

Section: Mi-associated Transcript (Miat-also Referred To Asmentioning

confidence: 99%

Lnc ing Epigenetic Control of Transcription to Cardiovascular Development and Disease

Rizki

Boyer

2015

Circulation Research

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Transcriptional and epigenetic regulation is critical for proper heart development, cardiac homeostasis, and pathogenesis. Long noncoding RNAs have emerged as key components of the transcriptional regulatory pathways that govern cardiac development as well as stress response, signaling, and remodeling in cardiac pathologies. Within the past few years, studies have identified many long noncoding RNAs in the context of cardiovascular biology and have begun to reveal the key functions of these transcripts. In this review, we discuss the growing roles of long noncoding RNAs in different aspects of cardiovascular development as well as pathological responses during injury or disease. In addition, we discuss diverse mechanisms by which long noncoding RNAs orchestrate cardiac transcriptional programs. Finally, we explore the exciting potential of this novel class of transcripts as biomarkers and novel therapeutic targets for cardiovascular diseases. ( Rizki and Boyer Long Noncoding RNAs in Cardiovascular Biology 193of fetal cardiac and stress response genes. 6,8,9 Despite these findings, transcriptional and epigenetic reprogramming of the failing heart is a complex process and the full spectrum of molecular determinants of these responses are waiting to be identified. Similar to developmental control mechanisms, noncoding RNAs are emerging players in post injury response cascades. In this review, we focus on the surge of recent studies that have begun to uncover the critical roles of lncRNAs in many different aspects of cardiovascular development, physiology, and disease.

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Steroid receptor RNA activator bi-faceted genetic system: Heads or Tails?

Cited by 53 publications

References 43 publications

Long Noncoding RNAs in Cardiac Development and Pathophysiology

Long Noncoding RNAs in Cardiac Development and Pathophysiology

A bi-faceted role of estrogen receptor β in breast cancer

Lnc ing Epigenetic Control of Transcription to Cardiovascular Development and Disease

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