Steroid receptor status of focal-nodular hyperplasia of the human liver

Bojar, Hans; Petzinna, Dieter; Brölsch, Ch.; Staib, W.

doi:10.1007/bf01726905

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…Therefore, prolonged OC intake and pregnancy have been suggested to be related to FNH pathogenesis (Davis et al 1975;Bartok et al 1980;Tajada et al 2001). Low levels of estrogen receptors have been detected in FNH (Bojar et al 1984), whereas expression of progesterone receptors was not demonstrated in FNH (Kubota et al 2001). However, in a large study on 216 women, neither the size nor number of FNH lesions were influenced by OC use, and pregnancy was not associated with FNH changes or complications (Mathieu et al 2000).…”

Section: Fnh and Fnh-like Nodules Associated With Steroid Hormonesmentioning

confidence: 99%

Focal Nodular Hyperplasia (FNH) of the Liver

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Focal nodular hyperplasia (FNH) of the liver is a reactive mass-forming regenerative hyperplastic response of hepatocytes, secondary to localized vascular and circulatory abnormalities. FNH has a predilection for young females and represents, after hemangioma, the second most common benign hepatic tumorous lesion of the liver in adults. Many FNH are asymptomatic and detected by chance, but a minority of FNH are associated with various symptoms mainly related to large size or atypical location. Most FNH are solitary lesions that are predominantly located in the right liver lobe. In a minority of patients, multiple lesions, sometimes exceeding 30, are present. Macroscopically, FNH are well-circumscribed nodular, yellowish to tan masses with a characteristic nodular texture, radiating septa, and a central stellate scar-like fibrotic structure. Part of the lesions protrude from the liver and can become pedunculated masses. The diameter of FNH may exceed 20 cm. Histologically, FNH is characterized by nodules that consist of normal-looking hepatocytes forming thin plates. These nodules are separated from each other by fibrous septa and interspersed portal tract-like structures. The latter lack interlobular bile ducts but contain ductular proliferations. The fibrous tissue areas contain abnormal thick-walled blood vessels.

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Section: Fnh and Fnh-like Nodules Associated With Steroid Hormonesmentioning

confidence: 99%

Focal Nodular Hyperplasia (FNH) of the Liver

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Progesterone receptor in hepatocellular carcinoma. Correlation with androgen and estrogen receptors

Nagasue

Kohno

Yamanoi

et al. 1991

Cancer

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Progesterone receptors (PgR), estrogen receptors (ER), and androgen receptors (AR) were assayed consecutively for hepatocellular carcinoma (HCC) that was surgically removed from 19 men and three women. The methods of receptor assay were the enzyme immunoassay (EIA) for PgR and the dextran-coated charcoal (DCC) technique for ER and AR. The patients ranged in age from 32 to 77 years (average, 60.3 years). No patients had received any specific anti-cancer therapy before tissue collection. All patients but one had underlying liver disease: cirrhosis in 13 and chronic hepatitis in eight. The positive rate of each receptor was 18% for PgR, 48% for ER, and 82% for AR. The titer was highest for AR, intermediate for ER, and lowest for PgR. The titers of PgR in four PgR-positive patients ranged from only 1.1 to 3.0 fmol/mg of protein. There was no relationship between PgR, ER, and AR in terms of positivity and titer. Also, other clinical and histopathologic data did not influence the positivity or concentration of these three sex hormone receptors. It can be concluded that no or little PgR exists in the cytosol of untreated HCC. Cancer 672501-2505,1991. HE EFFECT OF SEX HORMONES on liver function and T morphologic type has been recognized for several decades.' Since the first report by Baum and associates,2 the relation between the use of oral contraceptives, which usually contain estrogen and progestin, and the development of liver cell adenoma and hepatocellular carci-noma (HCC) is currently not der~iable.~.~ There is, however , no good evidence that the development of focal nodular hyperplasia (FNH) is influenced by exogenous hormonesSx6 although the sex ratio in FNH strongly favors women.7 On the other hand, long-term use of androgenic ana-bolic steroids occasionally induce such tumors in the All over the world HCC is more prevalent in men than in women. This is particularly true in patients with liver cirrhosis and in the geographic areas where this tumor is prevalent."

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Expression of estrogen receptor mRNA in tumorous and non-tumorous liver tissue as detected by in situ hybridization

et al. 1993

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Estrogen receptor mRNA was detected by a non-radioactive in situ hybridization assay in tumor and non-neoplastic liver tissues. A synthetic oligonucleotide complementary to the human estrogen receptor mRNA was 3'-labeled with digoxigenin-deoxyuridine triphosphate (dUTP). Hybrids were revealed by an alkaline phosphatase-conjugated anti-digoxigenin antibody. Fourteen primary hepatocellular carcinoma tissues (and one metastatic) were obtained at surgery from 15 patients. The corresponding nonneoplastic liver tissues were available in 13 cases. The estrogen receptor mRNA was detected in 1 1 tumorous and 7 non-tumorous liver specimens. The staining was cytoplasmic and involved the majority of transformed hepatocytes, whereas a less widespread and weaker signal was found in normal hepatocytes. Within non-neoplastic tissue, bile duct epithelial cells could also be occasionally stained, whereas other cell types, such as vasal endothelial cells, were negative. Appropriate controls established the specificity of the reaction. Detection of the estrogen receptor protein by immunohistochemistry in these same specimens was invariably negative. This in situ hybridization assay can therefore be used as a complementary tool to evaluate the estrogen receptor expression within liver cancer. 0 1993 Wiley-Liss, Inc.

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Steroid receptor status of focal-nodular hyperplasia of the human liver

Cited by 7 publications

References 14 publications

Focal Nodular Hyperplasia (FNH) of the Liver

Focal Nodular Hyperplasia (FNH) of the Liver

Progesterone receptor in hepatocellular carcinoma. Correlation with androgen and estrogen receptors

Expression of estrogen receptor mRNA in tumorous and non-tumorous liver tissue as detected by in situ hybridization

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