Steroid Therapy in Oral Lichen Planus

Alerraqi, Ebtissam

doi:10.4172/2157-7536.1000173

Cited by 4 publications

(5 citation statements)

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“…The majority of the patients (60%) complained of oral discomfort either in the form of burning sensation or pain as reported in other studies (Bakhtiari, 2017). Nearly 75% of the erosive lichen planus was treated using systemic steroids like Prednisone for a maximum period of eight months (Alerraqi, 2016;Kurt et al, 2019). During the later follow-up, it was noted that the patients responded well with systemic steroid therapy when compared to topical steroid therapy.…”

Section: Resultsmentioning

confidence: 99%

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Correlation Of Clinical Severity Of Oral Lichen Planus With Treatment Prognosis - A Retrospective Institution Based Study

Umashankar

Hannah

2020

ijrps

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Lichen planus is a chronic mucocutaneous immunologically mediated disease which is triggered by varied etiological agents. Lichen planus shows many clinical features affecting the skin, oral cavity, genital organ, nail and scalp. Lichen planus has well documented clinical findings and histological findings that aid in diagnosis. This retrospective study was done to assess the clinical severity of Oral Lichen Planus (OLP) and compare it to the treatment prognosis of the patients visiting our institution. A total of 60 clinically diagnosed OLP patients were included. Clinical and treatment details were recorded and tabulated using Excel. The collected data were then analyzed by appropriate statistics using SPSS software. The results revealed 60% of the cases to be females with 58.3% accounting for the erosive type of lichen planus. 60% had involvement of bilateral buccal mucosa. Erosive variant showed eight months duration of treatment using systemic steroids. Within the limitations of the study, we observed that OLP accounts for nearly 28.4% of the OPMD reporting to the institution and females were found to be more commonly affected than males. Erosive lichen planus was the most common variant which exhibited maximum treatment duration. Hence, it is necessary to follow up the OLP patients regularly and to provide a precise treatment which prevents the remission of the disease in these patients.

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Section: Resultsmentioning

confidence: 99%

“…Even though there is no speci ic treatment for OLP, symptomatic treatment is indicated (Jayaraj et al, 2015;Jangid, 2015). Corticosteroids provide relief and are the irst drug of choice (Swathy et al, 2015;Alerraqi, 2016). The reticular type has a better response to steroids when compared to erosive form (Bakhtiari, 2017;Hasan, 2020).…”

Section: Resultsmentioning

confidence: 99%

Correlation Of Clinical Severity Of Oral Lichen Planus With Treatment Prognosis - A Retrospective Institution Based Study

Umashankar

Hannah

2020

ijrps

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“…Steroid therapy is the mainstay of treatment of OLP [18]. A Cochrane review in 2011 found that there were no randomised clinical trials that compared steroids with placebo, and concluded that there is no evidence that one steroid is any more effective than another [19].…”

Section: Discussionmentioning

confidence: 99%

‘Nasal flossing’: A case report of nasopharyngeal stenosis due to severe erosive lichen planus and a novel therapeutic intervention

Henry

Biddlestone

McCaul

2019

International Journal of Surgery Case Reports

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HighlightsAn unusual case of nasopharyngeal stenosis following severe erosive oral lichen planus is described.Initial surgical management was complicated by recurrent nasopharyngeal stenosis due to the intense underlying inflammatory disease process.‘Nasal flossing’ is described as a novel technique that can be used as an adjunct to prevent recurrence of nasopharyngeal stenosis and has relevance to a broad range of oral and nose and throat physicians.

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“…Penyakit ini biasanya terjadi pada pasien dengan usia paruh baya dan sedikit lebih banyak terjadi pada perempuan. 1 Etiologi dari lichen planus masih belum diketahui. Hal ini mungkin disebabkan karena banyak penyebab berbeda yang menimbulkan gambaran klinis dan histologis yang mirip.…”

Section: Pendahuluanunclassified

Efektivitas Injeksi Intralesi Beberapa Jenis Obat Pada Terapi Oral Lichen Planus : Tinjauan Sistematik

Yusuf

Nur'aeny

2022

Bdent

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Injeksi intralesi, Oral lichen planus, TerapiPendahuluan: Oral lichen planus merupakan penyakit inflamasi kronik dengan etiologi yang tidak diketahui. Sistem imun berperan dalam penyakit OLP ini karena secara histopatologis terlihat infiltrasi pita sub-epitelial yang didominasi oleh limfosit T dan makrofag. Stres, genetik, makanan, obat-obatan, plak gigi, penyakit sistemik dan kebersihan mulut yang buruk diduga memicu terjadinya OLP. Terapi penyakit ini biasanya menggunakan kortikosteroid topikal triamcinolone acetonide baik berupa salep, obat kumur, spray, atau pasta maupun sistemik kortikosteroid seperti prednisolon dan prednison, namun pada beberapa pasien terdapat efek samping kortikosteroid sistemik maupun topikal yang tidak diinginkan seperti moon face dan hirsutism. Injeksi kortikesteroid intralesional termasuk ke dalam terapi topikal dan dapat digunakan untuk mengurangi efek samping tersebut. Tujuan dari tinjauan sistematik ini untuk menyajikan informasi mengenai efektivitas dan jenis obat yang digunakan dalam perawatan OLP dengan teknik injeksi intralesional. Metode: Pencarian literatur dilakukan dengan database elektronik termasuk PubMed dan Google Scholar. Artikel yang dimasukkan hanya dalam Bahasa Inggris dan Bahasa Indonesia, dengan kata kunci injeksi intralesional, oral lichen planus, terapi, dan penyaringan studi kohort, randomized controlled trial dan penelitian dari tahun 2010 sampai 2020. Hasil: Sebanyak 1.179 artikel diperoleh sesuai kata kunci injeksi intralesional, oral lichen planus, terapi, tetapi setelah mengeliminasi duplikasi dan skrining berdasarkan abstrak didapatkan hasil sebanyak 8 artikel, dengan 4 jenis obat yang sering dipakai untuk terapi injeksi intralesi pada OLP, yaitu Triamcinolone acetonide, Bacillus Calmette Guerin-Polysaccharide Nucleic Acid (BCG-PSN), betamethason dan bevacizumab. Simpulan: Injeksi intralesi dengan obat Triamcinolone acetonide, bethametasone, BCG-PSN dan bevacizumab efektif dalam mengobati oral lichen planus.

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Steroid Therapy in Oral Lichen Planus

Cited by 4 publications

References 10 publications

Correlation Of Clinical Severity Of Oral Lichen Planus With Treatment Prognosis - A Retrospective Institution Based Study

Correlation Of Clinical Severity Of Oral Lichen Planus With Treatment Prognosis - A Retrospective Institution Based Study

‘Nasal flossing’: A case report of nasopharyngeal stenosis due to severe erosive lichen planus and a novel therapeutic intervention

Efektivitas Injeksi Intralesi Beberapa Jenis Obat Pada Terapi Oral Lichen Planus : Tinjauan Sistematik

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