Steroidal epoxides as anticancer agents in lung, prostate and breast cancers: The case of 1,2-epoxysteroids

Gomes, Ana R.; Tavares-da-Silva, Elisiário J.; Costa, Saúl C.; Varela, Carla L.; Abrantes, Ana M.; Gonçalves, Ana C.; Alves, Raquel; Botelho, Maria F.; Roleira, Fernanda M.F.; Pires, Ana S.

doi:10.1016/j.bcp.2024.116266

Biochemical Pharmacology

2024

DOI: 10.1016/j.bcp.2024.116266

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Steroidal epoxides as anticancer agents in lung, prostate and breast cancers: The case of 1,2-epoxysteroids

Ana R. Gomes,

Elisiário J. Tavares-da-Silva,

Saúl C. Costa

et al.

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2024

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Antimicrobial Activity of Copolymer Structures from Bio-Based Monomers

Fernandes,

Branco,

Pereira

et al. 2024

Biomacromolecules

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The urgent need for new antimicrobial compounds has led scientists to explore antimicrobial peptides (AMPs) and antimicrobial polymers as solutions for multidrug resistance. In this study, we synthesized copolymers with cationic and hydrophobic moieties by freeradical polymerization (FRP) using a chain transfer agent to control molecular weights. The potential of natural products as part of the hydrophobic moiety was evaluated, along with variations in their monomer content (13−25%) and the molecular weight (MW) of the copolymer (5000−20,000 g•mol −1 ). Hydrophobicity was evaluated using the theoretical Log P oct values and surface areas (SAs). Biological assays included antimicrobial activity against Escherichia coli and Staphylococcus aureus standard strains, hemolytic activity in red blood cells (RBC), and cytotoxicity tests against HEK293T cells. Keys findings indicate that copolymers with tropolone moieties, lower MWs, and an optimal balance between hydrophobic and cationic moieties show a promising basis for future generations of antimicrobials.

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Antimicrobial Activity of Copolymer Structures from Bio-Based Monomers

Fernandes,

Branco,

Pereira

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

show abstract

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Steroidal epoxides as anticancer agents in lung, prostate and breast cancers: The case of 1,2-epoxysteroids

Cited by 1 publication

References 42 publications

Antimicrobial Activity of Copolymer Structures from Bio-Based Monomers

Antimicrobial Activity of Copolymer Structures from Bio-Based Monomers

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