Steroidal glycoalkaloids in Solanum chacoense

Mweetwa, Alice M.; Hunter, Danielle; Poe, Rebecca; Harich, Kim; Ginzberg, Idit; Veilleux, Richard E.

doi:10.1016/j.phytochem.2011.12.003

Cited by 34 publications

(42 citation statements)

References 34 publications

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“…S. chacoense, which produces a high concentration of leptines, and 16 SHs and BC 1 clones also showed the specific sequence of 250 bp. 36 This is similar to the findings of Bouarte-Medina et al 26 This sequence was not detected in cultivated potato and 11 of the SHs and BC 1 clones that proved to be susceptible to CPB.…”

Section: Resultssupporting

confidence: 88%

Mismatch repair deficiency increases the transfer of antibiosis and antixenosis properties against Colorado potato beetle in somatic hybrids ofSolanum tuberosum+S. chacoense

et al. 2016

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Section: Resultssupporting

confidence: 88%

Mismatch repair deficiency increases the transfer of antibiosis and antixenosis properties against Colorado potato beetle in somatic hybrids ofSolanum tuberosum+S. chacoense

et al. 2016

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“…The results show that (a) fruits of S. aethiopicum and S. melongena contained (in mg/100 g fresh weight) 0.58− 4.56 α-solamargine and 0.17−1.0 α-solasonine and (b) the corresponding much higher values for S. macrocarpon are 124− 197 and 16−23, respectively, suggesting that this accession might not be safe for consumption. A related study of 10 eggplant lines and three allied species (S. aethiopicum, S. integrifolium, and S. sodomaeum) confirmed that the allied species had higher glycoalkaloid content than the widely consumed eggplants and that the glycoalkaloid content 137,140,141 Journal of Agricultural and Food Chemistry Review generally increased during fruit development and ripening. 11 Bajaj et al 12 used colorimetry to determine an average glycoalkaloid content of 21 eggplant varieties, whose concentrations (in mg/100 g fresh weightt) ranged from 6.25 to 20.5 or 3.3-fold variation from the lowest to the highest value.…”

Section: ■ Introductionmentioning

confidence: 91%

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Friedman¹

2015

J. Agric. Food Chem.

174

106

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Inhibition of cancer can occur via apoptosis, a genetically directed process of cell self-destruction that involves numerous biomarkers and signaling pathways. Glycoalkaloids are nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants, potatoes, and tomatoes. Exposure of cancer cells to glycoalkaloids produced by eggplants (α-solamargine and α-solasonine), potatoes (α-chaconine and α-solanine), and tomatoes (α-tomatine) or their hydrolysis products (mono-, di-, and trisaccharide derivatives and the aglycones solasodine, solanidine, and tomatidine) inhibits the growth of the cells in culture (in vitro) as well as tumor growth in vivo. This overview comprehensively surveys and consolidates worldwide efforts to define the following aspects of these natural compounds: (a) their prevalence in the three foods; (b) their chemistry and structure-activity relationships; (c) the reported factors (biomarkers, signaling pathways) associated with apoptosis of bone, breast, cervical, colon, gastric, glioblastoma, leukemia, liver, lung, lymphoma, melanoma, pancreas, prostate, and squamous cell carcinoma cell lines in vitro and the in vivo inhibition of tumor formation and growth in fish and mice and in human skin cancers; and (d) future research needs. The described results may make it possible to better relate the structures of the active compounds to their health-promoting function, individually, in combination, and in food, and allow the consumer to select glycoalkaloid-containing food with the optimal content of nontoxic beneficial compounds. The described findings are expected to be a valuable record and resource for further investigation of the health benefits of food-related natural compounds.

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“…For example, in legumes, β-amyrin and lupeol have been detected in nodule tissues (Hartmann et al ., 2002 ), and sprouting has been reported to increase both β-amyrin and saponin content of seedlings (Ayet et al ., 1997 ; Baisted, 1971 ; Guajardo-Flores et al ., 2012 ; Livingston et al ., 1984 ). Likewise, in Solanum species, differential tissue- and organ-specific synthesis and accumulation of steroidal glycoalkaloids has been observed (Mweetwa et al ., 2012 ). Synthesis commences during germination and peaks in the flowering period.…”

Section: Occurrence and Distribution In Plantsmentioning

confidence: 99%

Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives

Moses

Papadopoulou

Osbourn

2014

Critical Reviews in Biochemistry and Molecular Biology

397

282

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Saponins are widely distributed plant natural products with vast structural and functional diversity. They are typically composed of a hydrophobic aglycone, which is extensively decorated with functional groups prior to the addition of hydrophilic sugar moieties, to result in surface-active amphipathic compounds. The saponins are broadly classified as triterpenoids, steroids or steroidal glycoalkaloids, based on the aglycone structure from which they are derived. The saponins and their biosynthetic intermediates display a variety of biological activities of interest to the pharmaceutical, cosmetic and food sectors. Although their relevance in industrial applications has long been recognized, their role in plants is underexplored. Recent research on modulating native pathway flux in saponin biosynthesis has demonstrated the roles of saponins and their biosynthetic intermediates in plant growth and development. Here, we review the literature on the effects of these molecules on plant physiology, which collectively implicate them in plant primary processes. The industrial uses and potential of saponins are discussed with respect to structure and activity, highlighting the undoubted value of these molecules as therapeutics.

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Steroidal glycoalkaloids in Solanum chacoense

Cited by 34 publications

References 34 publications

Mismatch repair deficiency increases the transfer of antibiosis and antixenosis properties against Colorado potato beetle in somatic hybrids ofSolanum tuberosum+S. chacoense

Mismatch repair deficiency increases the transfer of antibiosis and antixenosis properties against Colorado potato beetle in somatic hybrids ofSolanum tuberosum+S. chacoense

Chemistry and Anticarcinogenic Mechanisms of Glycoalkaloids Produced by Eggplants, Potatoes, and Tomatoes

Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives

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