Steroidal Glycosides from Reineckia carnea herba and Their Antitussive Activity

Han, Na; Chen, Ling Li; Wang, Yao; Xue, Rui; Zou, Li; Liu, Fang; Yin, Jun

doi:10.1055/s-0032-1328556

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…For example, the steroidal saponin RCE-4, a major active component of R. carnea, has been found to effectively induce apoptosis in cervical cancer cells [13]. Furthermore, certain steroidal glycosides isolated from R. carnea have shown promising in vitro antitussive activity [14]. However, the potential role and underlying molecular mechanisms of R. carnea in mitigating AD remain largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Reineckia carnea Ether Fraction against Alzheimer’s Disease Pathology: An Exploration in Caenorhabditis elegans Models

Fu,

Zhou,

et al. 2023

IJMS

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Alzheimer’s disease (AD) presents a significant challenge to global healthcare systems, with current treatments offering only modest relief and often bringing unwanted side effects, necessitating the exploration of more effective and safer drugs. In this study, we employed the Caenorhabditis elegans (C. elegans) model, specifically the AD-like CL4176 strain expressing the human Aβ(1–42) protein, to investigate the potential of Reineckia carnea extract and its fractions. Our results showed that the Reineckia carnea ether fraction (REF) notably diminished the paralysis rates of CL4176 worms. Additionally, REF also attenuated the neurotoxicity effects prompted by Tau proteins in the BR5270 worms. Moreover, REF was observed to counteract the accumulation of Aβ and pTau proteins and their induced oxidative stress in C. elegans AD-like models. Mechanistic studies revealed that REF’s benefits were associated with the induction of autophagy in worms; however, these protective effects were nullified when autophagy-related genes were suppressed using RNAi bacteria. Together, these findings highlight Reineckia carnea ether fraction as a promising candidate for AD treatment, warranting further investigation into its autophagy-inducing components and their molecular mechanisms.

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Section: Introductionmentioning

confidence: 99%

The Protective Effects of Reineckia carnea Ether Fraction against Alzheimer’s Disease Pathology: An Exploration in Caenorhabditis elegans Models

Fu,

Zhou,

et al. 2023

IJMS

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Steroids from herbs of Reineckia carnea and their anticomplement activities

Zhan

et al. 2018

Natural Product Research

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A new polyhydroxylated pregnane, named lβ,2β,3β,4β,5β,6β-hexolhydroxy-pregn-16-en-20-one (1), along with nine known (2-10) steroidal saponins were isolated from the whole plant of Reineckia carnea. Structure elucidations of all compounds were established by interpretation of their NMR spectral data, HR-ESI-MS and comparing with literatures. In addition, these compounds were evaluated with anticomplement activity. The result showed that compound 1 exhibited anticomplement effects with the CH values of 0.043 mg/mL, but saponins (2-10) showed no inhibition. Interestingly, hydrolysis of steroidal saponins (2-10) resulted in its aglycones (2a-10a) correspondingly which showed anticomplement activity with the CH values of 0.049-0.156 mg/mL.

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Three new steroidal components from the roots of reineckia carnea

Zheng

Zhang

et al. 2019

Natural Product Research

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A new coprostanol glycoside, 26-trihydroxy-16, 22-dioxo-3β-[(α-Lrhamnopyranosyl)oxy]-5β-cholestan-1β-yl O-α-L-rhamnopyranosyl-(1→2)-β-Dfucopyranoside (1) (25S)-5β-spirostan-1β,2β,3β,4β,5β,6β-hexol (2), a new C-22 steroidal lactone saponin, (20R)-16β-trihydroxy-3β-[(α-L-rhamnopyranosyl)oxy]-1β-[(O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl)oxy]-5β-pregnane-20-oic acid ᵧ-lactone (3) along with two known pregnane glycosides (4 and 5) were obtained from the roots of Reineckia carnea. Their structures were determined by 1D, 2D NMR, IR and MS data analysis. In addition, the cytotoxic activities in HT-29, HCT116, H1299 and A549 tumor cells of the isolated compounds (1 − 5) were determined by the MTT method. The results showed that only compound 1 exhibited weak effect against these cells with IC 50 values ranging from 63.36 μM to 105.01 μM.

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Steroidal Glycosides from Reineckia carnea herba and Their Antitussive Activity

Cited by 3 publications

References 9 publications

The Protective Effects of Reineckia carnea Ether Fraction against Alzheimer’s Disease Pathology: An Exploration in Caenorhabditis elegans Models

The Protective Effects of Reineckia carnea Ether Fraction against Alzheimer’s Disease Pathology: An Exploration in Caenorhabditis elegans Models

Steroids from herbs of Reineckia carnea and their anticomplement activities

Three new steroidal components from the roots of reineckia carnea

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