Steroidal lactams: a review

Ibrahim‐Ouali, Malika; DUMUR, Frédéric

doi:10.24820/ark.5550190.p011.773

Cited by 2 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Structure containing D-homo lactone moiety and ester of p-bis(2-chloroethyl)aminophenylacetic acid on C3 (27), along with its lactam analogs 28 and 29, are proven to be effective in causing markedly increased SCE (sisterchromatid exchange) rates and cell division delays in human lymphocytes [123]. In more recent research, compounds 27 and 28 showed good anticancer activity against pancreatic cancer cell lines [124,125]. The best GI 50 of 8 µM is observed for D-homo lactam 28 on Hs776T cells.…”

Section: Biologically Active Derivatives and Analogs Of Testolactonementioning

confidence: 99%

Testolactone: The Rise and Fall of a Drug

Savić

Kuzminac

Nikolić

2023

DDC

View full text Add to dashboard Cite

Testolactone is structurally related to testosterone and belongs to the first generation of aromatase inhibitors. It is a non-selective irreversible aromatase enzyme inhibitor that was one of the first steroids used in the clinical treatment of breast cancer. The use of testolactone in the treatment of breast cancer started in 1970, although its ability to inhibit aromatase was not discovered until 1975. Its use was primarily based on the inhibition of estrogen synthesis, which was applied in the treatment of estrogen-dependent breast cancers, in the treatment of disorders of sex steroid excess, familial male-limited precocious puberty, or in the treatment of patients with McCune–Albright syndrome, etc. The weak inhibitory activity of testolactone, and the moderate clinical response, prevented its widespread use, which ultimately resulted in withdrawal from the drug market in 2008. This review paper is dedicated to testolactone, its rise in the second half of the 20th century, and its fall in the first decade of the 21st century. Regardless of withdrawal from the market, for many years testolactone was a drug that improved the quality of life of patients facing one of the most serious diseases today, and for this reason, this paper describes medicinal application, synthesis, and modifications of testolactone.

show abstract

Section: Biologically Active Derivatives and Analogs Of Testolactonementioning

confidence: 99%

Testolactone: The Rise and Fall of a Drug

Savić

Kuzminac

Nikolić

2023

DDC

View full text Add to dashboard Cite

show abstract

“…Their use in photopolymerization has been widely reported by Dumur and coworkers. 62 , 63 , 64 Coumarins are flavonoid type of secondary metabolites present in (green) plants and have been intensively studied due to promising antioxidant and anti-cancer properties. 65 Moreover, coumarins have been used in sensing, detecting or fluorescence applications.…”

Section: Natural Photoinitiating Systemsmentioning

confidence: 99%

“…However, with proper derivatization and substitution of the chalcone core, the photoelectric properties can be fine-tuned and shifted to the blue-green region. 63…”

Section: Natural Photoinitiating Systemsmentioning

confidence: 99%

Natural and Naturally Derived Photoinitiating Systems for Light-Based 3D Printing

2022

View full text Add to dashboard Cite

Photoinitiating systems (PIS) are key components in photocurable formulations (inks) for 3D printing. Natural PIS are promising and more environmentally friendly alternatives to conventional photoinitiators. These systems offer enhanced features such as less toxicity and therefore, higher biocompatibility. Furthermore, they can be found in a large "color palette” variety (absorbing in the different regions of the UV-visible spectrum) enabling new possibilities in the field of 3D printing. In this review, we outline the current efforts to implement natural and naturally derived PIS in light-based 3D printing. First, recently applied natural PIS and their performance for light-based 3D printing are discussed. In a second part, an overview of naturally derived PIS including the most common synthetic strategies are provided. Last, current challenges as well as future perspectives of the field are discussed.

show abstract

Steroidal lactams: a review

Cited by 2 publications

References 34 publications

Testolactone: The Rise and Fall of a Drug

Testolactone: The Rise and Fall of a Drug

Natural and Naturally Derived Photoinitiating Systems for Light-Based 3D Printing

Contact Info

Product

Resources

About