Steroidal sapogenins and glycosides from the fibrous roots of Polygonatum odoratum with inhibitory effect on tissue factor (TF) procoagulant activity

Zhang, Hong; Chen, Ling; Kou, Junping; Zhu, Daling; Qi, Jin; Yu, Boyang

doi:10.1016/j.steroids.2014.07.002

Cited by 26 publications

(14 citation statements)

References 25 publications

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“…3-O-β-D-Galactopyranosyl diosgenin [25] (6a), yield 95.1%, a white solid, 1 : 141.2, 121.6, 109.2, 103.3, 81.1, 78.2, 74.5, 72.4, 69.4, 66.9, 66.8, 62.8, 56.6, 50.2, 41.9, 41.0, 40.4, 39.8, 37.3, 37.0, 32.6, 32.2 3-O-α-L-Rhamnopyranosyl diosgenin [27] (6d), yield 93.5%, a white solid, 1 Then the medium was discarded and 200 μL of DMSO was added to each well to dissolve the blue crystal. The absorbance was read on a microplate reader(Bio-Rad, USA) and the cell viability after drug intervention was normalized with vehicle treated cells.…”

Section: General Procedures For Syntheses Of Compounds 6a-6imentioning

confidence: 99%

Syntheses and anti-cancer activities of glycosylated derivatives of diosgenin

Tan

Xiao

Jianing

et al. 2016

Chem. Res. Chin. Univ.

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In order to obtain better anti-cancer compounds, nine glycosylated derivatives were designed and synthesized using diosgenin as starting material. Their structures were confirmed by 1 H NMR, 13 C NMR and MS spectra. The anti-cancer activities of intermediate compounds 5a-5i and the target compounds 6a-6i were investigated against human leukemia HEL, K562, HL60 and melanoma WM9 cell lines via MTT method. The bioassay results show that these derivatives possess good inhibitory activities against the four cancer cell lines. Furthermore, these derivatives show better inhibitory activities against K562 than against other cell lines, and most derivatives show better inhibitory activities than the parental material. Moreover, compounds 6a-6i are more active than their intermediates 5a-5i when against these cells. The above results demonstrate the effects of glycosylation on 3 -OH of diosgenin and acetylation of the sugar moiety on their antitumor activities.

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Section: General Procedures For Syntheses Of Compounds 6a-6imentioning

confidence: 99%

Syntheses and anti-cancer activities of glycosylated derivatives of diosgenin

Tan

Xiao

Jianing

et al. 2016

Chem. Res. Chin. Univ.

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“…Traditional herbal medicines with anti-cancer properties that trigger apoptosis in various types of tumor cells with minimal adverse effects have been valuable sources for therapeutic agents. Polygonatum odoratum is widely used as an herbal medicine with procoagulant ( 15 ), anti-hyperglycemic ( 16 ), anti-herpes simplex virus-II, and apoptosis-inducing ( 17 ) activities, that can also improve glucose tolerance ( 18 ). However, the active components in P. odoratum for the anti-cancer effects and the underlying mechanisms of these effects remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Homoisoflavanone‑1 isolated from Polygonatum�odoratum arrests the cell cycle and induces apoptosis in A549 cells

Ning

Jin

et al. 2018

Oncol Lett

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Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner. Homoisoflavanone-1 arrested the cell cycle at the G2/M stage, which was associated with an increase in the accumulation of phosphorylated (p-)p38, p38, p53, and p-cyclin dependent kinase (Cdc)2 proteins, as well as a decrease in Cdc2 expression. In addition, treatment with homoisoflavanone-1 increased the levels of active caspase-3 and decreased Poly ADP-ribose polymerase, which was accompanied by a reduction in the B-cell lymphoma-2/Bak ratio and consequently, apoptosis. Furthermore, homoisoflavanone-1 increased the expression of endoplasmic reticulum (ER) stress-related proteins, including PERK, ATF4 and GADD34 in a dose-dependent manner. In conclusion, homoisoflavanone-1 induced apoptosis in A549 cells by regulating the mitochondria-caspase-dependent and ER stress pathways and resulted in G2/M arrest by activating the p38/p53 signaling pathway. These findings suggest that homoisoflavanone-1 extracted from Polygonatum odoratum may function as a cancer-suppressing agent and has potential as a novel therapeutic method against NSCLC.

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“…Its rhizome, also referred to as "YuZhu", "WaiSheng", "WeiRui", or "LingDangCai" in Chinese, has been widely used as an ingredient or supplement in food supplies. Additionally, it is a well-known Chinese traditional medicine that functions in removing dryness, quenching thirst, promoting fluid secretion, and treatment of diverse diseases, including fatigue, hypo-immunity, diabetes, and cardiovascular disease [11,12]. Many studies have reported the biological activities of steroids, dipeptides, flavonoids, and polysaccharides isolated from P. odoratum [13].…”

Section: Introductionmentioning

confidence: 99%