Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism

Huang, Dan; Dong, Xin Qi; Li, Jianzhe; Chen, Yudan; Zhou, Ying; Chen, Qingjie; Sun, Yuewen

doi:10.1007/s12032-023-02000-1

Cited by 10 publications

(5 citation statements)

References 38 publications

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“…SSPH I was found to induce ferroptosis in HepG2 liver cancer cells. This was confirmed by an increase in ROS, malondialdehyde, transferrin, and ferroportin proteins and a decrease in glutathione levels following the SSPH I treatment [44]. Dioscin had cytotoxic effects against melanoma cell lines A375, G361, and WM115 via ferroptosis induction.…”

Section: Ferroptosismentioning

confidence: 66%

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Bouabdallah,

Al-Maktoum,

Amin

2023

Cancers

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Cancer is a global health burden responsible for an exponentially growing number of incidences and mortalities, regardless of the significant advances in its treatment. The identification of the hallmarks of cancer is a major milestone in understanding the mechanisms that drive cancer initiation, development, and progression. In the past, the hallmarks of cancer have been targeted to effectively treat various types of cancers. These conventional cancer drugs have shown significant therapeutic efficacy but continue to impose unfavorable side effects on patients. Naturally derived compounds are being tested in the search for alternative anti-cancer drugs. Steroidal saponins are a group of naturally occurring compounds that primarily exist as secondary metabolites in plant species. Recent studies have suggested that steroidal saponins possess significant anti-cancer capabilities. This review aims to summarize the recent findings on steroidal saponins as inhibitors of the hallmarks of cancer and covers key studies published between the years 2014 and 2024. It is reported that steroidal saponins effectively inhibit the hallmarks of cancer, but poor bioavailability and insufficient preclinical studies limit their utilization.

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Section: Ferroptosismentioning

confidence: 66%

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Bouabdallah,

Al-Maktoum,

Amin

2023

Cancers

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“…This leads to the accumulation of Fe 2+ and subsequent iron overload, ultimately inducing ferroptosis. 121 Additionally, SSPH I induces a notable G2/M blockade in HepG2 cells. 121 …”

Section: Ferroptosis Inducersmentioning

confidence: 99%

“…This leads to the accumulation of Fe 2+ and subsequent iron overload, ultimately inducing ferroptosis. 121 Additionally, SSPH I induces a notable G2/M blockade in HepG2 cells. 121 Polyphyllin B (PB) is a dioscin isolated from Paris formosana with antitumor activity and immunomodulatory effects.…”

mentioning

confidence: 99%

“…121 Additionally, SSPH I induces a notable G2/M blockade in HepG2 cells. 121 Polyphyllin B (PB) is a dioscin isolated from Paris formosana with antitumor activity and immunomodulatory effects. 122 Can Hu et al found that PB could effectively inhibit the proliferation of GC cells by inducing ferroptosis and apoptosis, and could prevent the migration, invasion and cell cycle of tumor cells in vitro.…”

mentioning

confidence: 99%

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Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Luo,

Bai,

Zhang

et al. 2024

DDDT

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“…Esculetin [223], caryophyllene oxide [224], d-Borneol [225], and electrophilic sesquiterpenes isolated from Eupatorium chinense L. [226] could trigger ferroptosis of liver cancer cells through activating NCOA4-mediated ferritinophagy. In addition, SSPH I, a steroidal saponin isolated from Schizocapsa plantaginea Hance, could also upregulate the expression of TFR1 and FPN, leading to iron overload and inducing ferroptosis [227]. SLC7A11-GSH-GPX4 axis is the key antioxidant pathway against ferroptosis.…”

Section: Artesunatementioning

confidence: 99%

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body, the liver is crucial for iron storage and lipid metabolism. The liver seems to be closely related to ferroptosis through iron and lipid metabolism. Liver disease greatly threatens host health, and exploring effective interventions is essential. Mounting studies have demonstrated that ferroptosis is one of the possible pathogenic mechanisms involved in liver disease. Targeting ferroptosis may provide a promising opportunity for treating liver disease. However, drugs targeting ferroptosis are extremely limited. Therefore, it is an urgent need to develop new and safe ferroptosis regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, have recently shown great therapeutic potential in liver disease via modulating ferroptosis-related genes or pathways. Here, we outline the molecular mechanism of ferroptosis and systematically summarize the regulatory function of NAC on ferroptosis in liver disease. Finally, we discuss the application prospects and potential problems concerning NAC as ferroptosis regulators for managing liver disease.

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Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism

Cited by 10 publications

References 38 publications

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

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