Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity

Wang, Jing; Shi, Hua; Wu, Xiaoxue; Zhang, Shuyi; Gao, Xuemin; Li, Fu-Nan; Zhu, Xuan; Chen, Qing

doi:10.3390/molecules23030579

Cited by 27 publications

(17 citation statements)

References 22 publications

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“…Free radicals are unstable molecules that cause oxidative stress, triggering cell damage, antioxidants are substances that may prevent or delay cell deterioration, vegetables and fruits are a rich source of antioxidants (Lobo et al, 2010). The percentage of free radical scavenging activity was found to be significantly low, which may be due to a lower concentration of phenol (Wang et al, 2018) and flavonoids in the present study (Liu et al, 2018). Lin et al (2016) observed mild antioxidant activity in the essential oil of A. chinense bulb which supports the present findings.…”

Section: Antioxidant Assaysupporting

confidence: 85%

GC-MS based metabolite profiling and antioxidant activity of solvent extracts of Allium chinense G Don leaves

et al. 2021

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Allium chinense, a main source of “Xiebai” drug in Chinese traditional medicine and commonly known as Ganoderma lucidum belongs to the family Amaryllidaceae. The main focus of this research was to quantify the secondary metabolites, antioxidant potential and study the GC- MS based metabolite profile of different solvent leaf extracts of A. chinense. The reports on the bioactive compounds of A. chinense leaves are still insufficient compared to the bulb; hence this study was carried out to understand the bioactive compounds present in A. chinense leaves using different solvents of varying polarity. Our investigation showed that the ethanol extract contained the highest saponin, flavonoid, phenol, and DPPH scavenging activity. Further, metabolite profiling revealed a total of forty-eight compounds, indicating a diverse range of phytochemicals present in the four extracts. The highest number of compounds were observed in ethanol extract (15) followed by chloroform extract (13), petroleum ether extract (11) and methanol extract (9). Some of the major compounds identified in the four solvents are octacosane (27.11%), heptadecane (19.66%), eicosane (18.51%), ethyl palmitate (18.50%), phytol (17.68%) and phytol acetate (17.30%). In conclusion, this study highlights that A. chinense leaf extracts contain high saponins, terpenes and alkanes which could be a potential source of a new beneficial drug.

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Section: Antioxidant Assaysupporting

confidence: 85%

GC-MS based metabolite profiling and antioxidant activity of solvent extracts of Allium chinense G Don leaves

et al. 2021

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“…They are mainly distributed among monocotyledonous families: Amarillidaceae (Agapanthus, Allium), Asparagaceae (Agave, Anemarrhena, Asparagus, Convallaria, Hosta, Nolina, Ophiopogon, Ornithogalum, Polygonatum, Ruscus, Sansevieria, Tupistra, Yucca), Costaceae (Costus), Dioscoreaceae (Dioscorea), Liliaceae (Fritillaria, Lilium), Melanthiaceae (Paris), Smilacaceae (Smilax). Although it is uncommon, steroidal saponins can also be found in some dicotyledonous angiosperms, such as: Fabaceae (Trigonella), Zygophyllaceae (Tribulus, Zygophyllum), Solanaceae (Solanum, Lycopersicon, Capsicum), Asteraceae (Vernonia), and Plantaginaceae (Digitalis) (Faizal and Geelen 2013;Rahman et al 2017;Lanzotti 2005;Sobolewska et al 2016;Tang et al 2013;Wang et al 2018). Moreover, these compounds have been identified in starfish and marine sponges (Ivanchina et al 2011; Barnett et al 1988;Regaldo et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

et al. 2020

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Steroidal saponins are a group of glycosides widely distributed among monocotyledonous families. They exert a wide spectrum of biological effects including cytotoxic and antitumor properties which are the most studied. This review is an update of our previous paper-Saponins as cytotoxic agents (Podolak et al. in Phytochem Rev 9:425-474, 2010) and covers studies that were since published (2010-2018). In this paper we refer to steroidal saponins presenting results of cytotoxicity studies, mechanisms of action and structure-activity relationships.

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“…foam. The Venoniamyosides family was characterized by the peaks at 1456, 1507 (C=C aromatic stretching), 1771 (unsaturated aliphatic ester and carbonyl C=O) and 3392 cm -1 (OH groups) (Wang, Song et al 2018). The intensity ratio of foam and initial extracts at these peaks (1456, 1507, 1771 and 3392 cm -1 ) were 1.6, 2.1, 1.8 and 2.2, respectively.…”

Section: Identification Of V Amygdalina Extracted Substances By Ftirmentioning

confidence: 99%

“…The resolution setting was 2 cm -1 . The peaks detection was based on reported vibronic FTIR peaks assignments (Tawata, Taira et al 1996, Gao, Ci et al 2000, Shao, Guo et al 2007, Abbas, Compère et al 2017, Tambe, Patil et al 2017, Wang, Song et al 2018).…”

Section: Ftir Analysis Of Extractmentioning

confidence: 99%

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Improving the quality of Vernonia amygdalina extract by ultrasound‐assisted extraction coupled with gas bubble flotation

Luu¹,

Le²,

Le³

et al. 2019

J Food Process Engineering

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V. amygdalina (V.A) is an herb commonly used in folk medicine; it possesses various compounds with therapeutic capabilities. Traditional extraction approaches applied to this plant may destroy its bioactive compounds and inherently contaminate them with toxic organic solvents. In this study, ultrasound-assisted extraction combined with gas-bubble flotation was applied to increase V.A extraction yield. The efficiency of water maceration was increased by 200%, without the drawbacks of the conventional extraction methods. The total phenolic content yield was 189 ± 12.7 (mg GAE/g dry weight) with a condensation efficiency of 115 ± 5.7%; and the total flavonoid content was 6.44 ± 1.68 (mg QE/g dry weight). Additionally, the antioxidant activity of the condensed foam was enhanced up to 120%. Analysis of the extract by FTIR revealed the presence of extractable chemical families: sesquiterpene lactones, saponins and flavonoids, and that the chemical characteristics of the extract were also preserved This article is protected by copyright. All rights reserved. This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

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Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity

Cited by 27 publications

References 22 publications

GC-MS based metabolite profiling and antioxidant activity of solvent extracts of Allium chinense G Don leaves

GC-MS based metabolite profiling and antioxidant activity of solvent extracts of Allium chinense G Don leaves

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

Improving the quality of Vernonia amygdalina extract by ultrasound‐assisted extraction coupled with gas bubble flotation

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