Steroidomics of Pregnant Women at Advanced Age

Yu, Bin; Guo, Fang; Yang, Yuqi; Long, William M.; Zhou, Jun

doi:10.3389/fendo.2022.796909

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…In addition to protecting the fetus from maternal immune attacks, immune cells play critical roles in the migration and invasion of trophoblasts and in forming decidual blood vessels ( 54 ). The maternal corpus luteum and fetal placenta can signal the production of high levels of estrogen and progesterone ( 55 ), and interactions involving hormones and immune cells cannot be ignored.…”

Section: Mdscs In Embryo Implantationmentioning

confidence: 99%

“…During gestation, the maternal corpus luteum and fetal placenta can relay to produce high levels of estrogen and progesterone ( 55 ), and the interactions between hormones and MDSCs cannot be ignored. The MDSC count and frequency steadily increase during pregnancy and peak in the second trimester, showing parallel changes with the circulating estradiol and progesterone levels.…”

Section: Mdscs In Embryo Implantationmentioning

confidence: 99%

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Myeloidderived suppressor cells: Escorts at the maternal–fetal interface

Pang

et al. 2023

Front. Immunol.

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Myeloid-derived suppressor cells (MDSCs) are a novel heterogenous group of immunosuppressive cells derived from myeloid progenitors. Their role is well known in tumors and autoimmune diseases. In recent years, the role and function of MDSCs during reproduction have attracted increasing attention. Improving the understanding of their strong association with recurrent implantation failure, pathological pregnancy, and neonatal health has become a focus area in research. In this review, we focus on the interaction between MDSCs and other cell types (immune and non-immune cells) from embryo implantation to postpartum. Furthermore, we discuss the molecular mechanisms that could facilitate the therapeutic targeting of MDSCs. Therefore, this review intends to encourage further research in the field of maternal–fetal interface immunity in order to identify probable pathways driving the accumulation of MDSCs and to effectively target their ability to promote embryo implantation, reduce pathological pregnancy, and increase neonatal health.

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Section: Mdscs In Embryo Implantationmentioning

confidence: 99%

Section: Mdscs In Embryo Implantationmentioning

confidence: 99%

Myeloidderived suppressor cells: Escorts at the maternal–fetal interface

Pang

et al. 2023

Front. Immunol.

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Menopausale Übergangsphase und Postmenopause

Amrani

2023

Gynäkologische Endokrinologie Und Kinderwunschtherapie

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Estradiol and progesterone from pregnancy to postpartum: a longitudinal latent class analysis

Dukic,

Johann,

Henninger

et al. 2024

Front. Glob. Womens Health

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IntroductionDuring the peripartum, women undergo significant hormonal changes that are crucial for fetal development and a healthy pregnancy and postpartum period for mother and infant. Although several studies have determined healthy norm ranges of estradiol and progesterone, there are discrepancies among the reports, rendering it unclear which hormone levels are linked to adverse health outcomes. To account for the impact of sex steroid patterns on health outcomes in mothers and children, a longitudinal assessment of different parameters is needed.Materials and methodsWe longitudinally assessed a cohort of 130 women over five months during pregnancy and postpartum. The women provided saliva samples and completed psychosocial questionnaires. Hormone analyses were conducted using enzyme-linked immunosorbent assay (ELISA). Different parameters of estradiol and progesterone were analyzed and evaluated in relation to psychometric variables. To examine the presence of heterogenous hormonal trajectories in the peripartum, we applied group-based trajectory modelling as a special case of latent-class group analysis.ResultsEstradiol and progesterone levels rose towards the end of pregnancy and dropped sharply after birth, with considerable individual variation, particularly during pregnancy. However, their ratio remained stable. We identified three estradiol trajectory subgroups and two progesterone subgroups. Age influenced progesterone levels, with older pregnant women having higher levels than younger women. Anxiety and depressive symptoms had a predictive value for trajectories of specific subgroups of women. The study also revealed two distinct subgroups regarding the course of estradiol and progesterone fluctuations as well as their ratio.ConclusionThis study provides insights into the course and fluctuation of salivary estradiol and progesterone levels among healthy women during the peripartum period, highlighting significant variations in hormone levels but stability in their ratio during this time. The finding of distinct sex steroid courses in the peripartum is new and suggests the need for further research to explore their impact on health outcomes. Our preliminary results suggest that hormonal fluctuations at the end of pregnancy appear to be a normal occurrence and might even be a protective factor for associated psychological symptoms and sleep disturbances in women.

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Steroidomics of Pregnant Women at Advanced Age

Cited by 3 publications

References 20 publications

Myeloidderived suppressor cells: Escorts at the maternal–fetal interface

Myeloidderived suppressor cells: Escorts at the maternal–fetal interface

Menopausale Übergangsphase und Postmenopause

Estradiol and progesterone from pregnancy to postpartum: a longitudinal latent class analysis

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