Steroids in the Treatment of Group A Streptococcal Necrotizing Soft Tissue Infection

Abstract

The cases illustrate the possible utility of high-dose steroids in the treatment of this process.

Intraoperative Patient-to-Healthcare-Worker Transmission of Invasive Group A Streptococcal Infection

“…Lack of glove use while caring for index patient; presence of dermatitis on affected skin Sablier et al 8 GAS necrotizing fasciitis 1 (necrotizing fasciitis) Transmission related to sharps injury incurred during initial debridement of index patient This study 1 GAS necrotizing fasciitis 2 (1 with necrotizing fasciitis with toxic shock syndrome, 1 with pharyngitis)…”

“…In June 2009, an extensive debridement of both lower extremities was performed on a 55-year-old patient with necrotizing fasciitis and myonecrosis following blunt injury (day 1), as reported previously. 1 The patient presented with septic shock and required urgent operative debridement and hip disarticulation. Blood and wound cultures grew Streptococcus pyogenes.…”

“…On day 8, surgeon B, who assisted with the disarticulation of the index patient's left hip, developed malaise, subjective fever, and chills, as reported previously. 1 The following day, erythema and edema of the right foot and thigh ensued. Physical examination was notable for extensive tinea pedis.…”

Prospective bacterial and fungal sources of hyaluronic acid: A review

“…Streptococcus pyogenes is a β-hemolytic group A streptococcus [230] , a human pathogen [165] , [231] , which causes puerperal sepsis [232] , tonsillitis [233] , toxic shock syndrome [234] , [235] , and necrotizing fasciitis [236] , [237] .…”

Necrotizing Soft-tissue Infections: An Orthopaedic Emergency

“…35 Corticosteroids have a similar, albeit less specific effect on the immune response to bacterial toxins have been used as an adjunct in patients with NSTI and toxic shock syndrome. 38 Hyperbaric oxygen treatment is theorized to aid in the prevention of the progression of tissue loss and therefore morbidity and mortality. However, in a Cochrane review, no literature worth of analysis was found, and no summation of data was suggested.…”