Sterol carrier protein 2 in lipid metabolism and non-alcoholic fatty liver disease: Pathophysiology, molecular biology, and potential clinical implications

Xu, Can; Li, Heng; Tang, Chao-Ke

doi:10.1016/j.metabol.2022.155180

Cited by 16 publications

(12 citation statements)

References 151 publications

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“…SCP2 is a lipid-binding protein that plays key roles a large variety of lipid trafficking and signaling. 61 SCP2 regulates lipids and fatty acids signaling pathways through lipid raft micro-domains of the plasma membrane in interaction with CAV1, which was also over-expressed in blastocysts from females exposed to high-fat diet of the present study. 62 Moreover, SCP2 is described to enhance cholesterol transfer from intracellular membranes to mitochondria.…”

Section: Discussionsupporting

confidence: 60%

Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit model

Calderari,

Archilla,

Jouneau

et al. 2023

J Dev Orig Health Dis

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The maternal metabolic environment can be detrimental to the health of the offspring. In a previous work, we showed that maternal high-fat (HH) feeding in rabbit induced sex-dependent metabolic adaptation in the fetus and led to metabolic syndrome in adult offspring. As early development representing a critical window of susceptibility, in the present work we aimed to explore the effects of the HH diet on the oocyte, preimplantation embryo and its microenvironment. In oocytes from females on HH diet, transcriptomic analysis revealed a weak modification in the content of transcripts mainly involved in meiosis and translational control. The effect of maternal HH diet on the embryonic microenvironment was investigated by identifying the metabolite composition of uterine and embryonic fluids collected in vivo by biomicroscopy. Metabolomic analysis revealed differences in the HH uterine fluid surrounding the embryo, with increased pyruvate concentration. Within the blastocoelic fluid, metabolomic profiles showed decreased glucose and alanine concentrations. In addition, the blastocyst transcriptome showed under-expression of genes and pathways involved in lipid, glucose and amino acid transport and metabolism, most pronounced in female embryos. This work demonstrates that the maternal HH diet disrupts the in vivo composition of the embryonic microenvironment, where the presence of nutrients is increased. In contrast to this nutrient-rich environment, the embryo presents a decrease in nutrient sensing and metabolism suggesting a potential protective process. In addition, this work identifies a very early sex-specific response to the maternal HH diet, from the blastocyst stage.

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Section: Discussionsupporting

confidence: 60%

Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit model

Calderari,

Archilla,

Jouneau

et al. 2023

J Dev Orig Health Dis

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“…Analysis based on TMT shows that DM has significantly downregulated nine genes and upregulated two genes in the PPAR pathway. The downregulation of plin2, scp2, and scd1 has demonstrated their positive involvement in improving lipid metabolism and reducing inflammation ( Libby et al, 2018 ; Tao et al, 2020 ; Xu et al, 2022 ). In the past two decades, PPARγ has attracted much attention as a transcription factor regulating glucose and lipid homeostasis ( Wang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Dendrobium mixture ameliorates type 2 diabetes mellitus with non-alcoholic fatty liver disease through PPAR gamma: An integrated study of bioinformatics analysis and experimental verification

et al. 2023

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Dendrobium mixture (DM) is a patented Chinese herbal medicine indicated which has anti-inflammatory and improved glycolipid metabolism. However, its active ingredients, targets of action, and potential mechanisms are still uncertain. Here, we investigate the role of DM as a prospective modulator of protection against non-alcoholic fatty liver disease (NAFLD) induced by type 2 diabetes mellitus (T2DM) and illustrate the molecular mechanisms potentially involved. The network pharmacology and TMT-based quantitative protomics analysis were conducted to identify potential gene targets of the active ingredients in DM against NAFLD and T2DM. DM was administered to the mice of DM group for 4 weeks, and db/m mice (control group) and db/db mice (model group) were gavaged by normal saline. DM was also given to Sprague-Dawley (SD) rats, and the serum was subjected to the palmitic acid-induced HepG2 cells with abnormal lipid metabolism. The mechanism of DM protection against T2DM-NAFLD is to improve liver function and pathological morphology by promoting peroxisome proliferator-activated receptor γ (PPARγ) activation, lowering blood glucose, improving insulin resistance (IR), and reducing inflammatory factors. In db/db mice, DM reduced RBG, body weight, and serum lipids levels, and significantly alleviated histological damage of liver steatosis and inflammation. It upregulated the PPARγ corresponding to the prediction from the bioinformatics analysis. DM significantly reduced inflammation by activating PPARγ in both db/db mice and palmitic acid-induced HepG2 cells.

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“…Recent scientific research has shown that SCP-2 has a favorable influence on NAFLD by effectively modulating many components of lipid metabolism, including cholesterol, endocannabinoid, and fatty acid pathways (22). Therefore, it is postulated that the impacts of Cynara scolymus may manifest via the stimulation and engagement of these hepatic metabolic pathways (22).…”

Section: Discussionmentioning

confidence: 99%

Role of Artichoke Leaf Extract as Antioxidant in Nonalcoholic Fatty Liver Disease of Adult Male Albino Rats

Zoair,

Abdelhay,

El-Said

2023

Benha Medical Journal

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Background:The artichoke plant, scientifically known as Cynara scolymus, is often planted in Mediterranean regions. It has a notable abundance of antioxidants. This research aims to evaluate the medical capacity of artichoke in modulating biochemical oxidant and antioxidant enzymes, as well as liver biomarkers, in adult male albino rats with nonalcoholic fatty liver disease. Methods: The rats were allocated into three distinct cohorts for the purpose of the study: a control group, a group that was provided with a high-fat diet to induce hyperlipidemia, and a group that received treatment with artichoke leaf extract. Following the conclusion of the experimental phase, blood samples were obtained and subjected to analysis to assess the lipid profile, liver enzyme activity, as well as the levels of malondialdehyde (MDA) and glutathione peroxidase (GSH-PX). Additionally, liver specimens had been subjected to examination using a light microscope. Results: Artichoke extract improved blood serum lipids in rats with NAFLD. Triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), very lowdensity lipoprotein (VLDL), and TC/HDL and LDL/HDL ratios decreased significantly. HDL values also rose. The treatment with artichoke extract to rats with NAFLD significantly reduced liver enzyme levels. In the group with non-alcoholic fatty liver disease (NAFLD), artichoke extract restored GSH and MDA levels to normal levels. Conclusions: The use of artichoke in rat models of non-alcoholic fatty liver disease (NAFLD) had a relation to diminished indicators of oxidative stress.

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Sterol carrier protein 2 in lipid metabolism and non-alcoholic fatty liver disease: Pathophysiology, molecular biology, and potential clinical implications

Cited by 16 publications

References 151 publications

Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit model

Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit model

Dendrobium mixture ameliorates type 2 diabetes mellitus with non-alcoholic fatty liver disease through PPAR gamma: An integrated study of bioinformatics analysis and experimental verification

Role of Artichoke Leaf Extract as Antioxidant in Nonalcoholic Fatty Liver Disease of Adult Male Albino Rats

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