Sterol-Sensing Domain (SSD)-Containing Proteins in Sterol Auxotrophic
            <i>Phytophthora capsici</i>
            Mediate Sterol Signaling and Play a Role in Asexual Reproduction and Pathogenicity

Wang, Weizhen; Xue, Zhaolin; Xie, Linfang; Zhou, Xin; Zhang, Fan; Zhang, Sicong; Govers, F.; Liu, Xili

doi:10.1128/spectrum.03797-22

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Cited by 5 publications

References 54 publications

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Sterol complex visualisation in Phytophthora cinnamomi and expression analysis of genes involved in sterol sensing, recruitment and conversion

Kharel,

Adcock,

Ziemann

et al. 2024

Physiological and Molecular Plant Pathology

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Sterol complex visualisation in Phytophthora cinnamomi and expression analysis of genes involved in sterol sensing, recruitment and conversion

Kharel,

Adcock,

Ziemann

et al. 2024

Physiological and Molecular Plant Pathology

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Harnessing CRISPR-Cas for oomycete genome editing

Vink¹,

Hayhurst²,

Gerth³

2023

Trends in Microbiology

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A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68

Sheng,

Ai,

Yang

et al. 2024

Nat Commun

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Oomycete pathogens deliver many effectors to enhance virulence or suppress plant immunity. Plant immune networks are interconnected, in which a few effectors can trigger a strong defense response when recognized by immunity-related proteins. How effectors activate plant defense response remains poorly understood. Here we report Phytophthora capsici effector RxLR23 KM can induce plant cell death and plant immunity. RxLR23 KM specifically binds to ERD15La, a regulator of abscisic acid and salicylic acid pathway, and the binding intensity depends on the amino acid residues (K 93 and M 320 ). NbNAC68, a downstream protein of ERD15La, can stimulate plant immunity that is compromised after binding with ERD15La. Silencing of NbNAC68 substantially prevents the activation of plant defense response. RxLR23 KM binds to ERD15La, releasing NbNAC68 to activate plant immunity. These findings highlight a strategy of plant defense response that ERD15La as a central regulator coordinates RxLR23 KM to regulate NbNAC68-triggered plant immunity.

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Sterol-Sensing Domain (SSD)-Containing Proteins in Sterol Auxotrophic Phytophthora capsici Mediate Sterol Signaling and Play a Role in Asexual Reproduction and Pathogenicity

Abstract: Phytophthora is an important genus of oomycetes that comprises many destructive plant pathogens. Due to the incompleteness of the sterol synthesis pathway, Phytophthora spp. do not possess the ability to produce sterols.

Cited by 5 publications

References 54 publications

Sterol complex visualisation in Phytophthora cinnamomi and expression analysis of genes involved in sterol sensing, recruitment and conversion

Sterol complex visualisation in Phytophthora cinnamomi and expression analysis of genes involved in sterol sensing, recruitment and conversion

Harnessing CRISPR-Cas for oomycete genome editing

A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68

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