Stevens Johnson syndrome and toxic epidermal necrolysis – an Australian analysis of treatment outcomes and mortality

Abstract

Johnson syndrome and toxic epidermal necrolysisan Australian analysis of treatment outcomes and mortalityArticle no: IJDT_A_1568380 Enclosures: 1) Query sheet 2) Article proofs 4. Funding: Was your research for this article funded by a funding agency? If so, please insert `This work was supported by <insert the name of the funding agency in full>', followed by the grant number in square brackets `[grant number xxxx]'. 5. Supplemental data and underlying research materials: Do you wish to include the location of the underlying research materials (e.g. data, samples or models) for your article? If so, please insert this sentence before the reference section: `The underlying research materials for this article can be accessed at <full link>/ description of location [author to complete]'. If your article includes supplemental data, the link will also be provided in this paragraph. See <http://journalauthors.tandf.co. uk/preparation/multimedia.asp> for further explanation of supplemental data and underlying research materials.6. The PubMed (http://www.ncbi.nlm.nih.gov/pubmed) and CrossRef databases (www.crossref.org/) have been used to validate the references. Changes resulting from mismatches are tracked in red font. AUTHOR QUERIESQ1:Please check the affiliations are correct as set.How to make corrections to your proofs using Adobe Acrobat/ReaderTaylor & Francis offers you a choice of options to help you make corrections to your proofs. Your PDF proof file has been enabled so that you can mark up the proof directly using Adobe Acrobat/Reader. This is the simplest and best way for you to ensure that your corrections will be incorporated. If you wish to do this, please follow these instructions:1. Save the file to your hard disk.2. Check which version of Adobe Acrobat/Reader you have on your computer. You can do this by clicking on the "Help" tab, and then "About".If Adobe Reader is not installed, you can get the latest version free from http://get.adobe.com/reader/.3. If you have Adobe Acrobat/Reader 10 or a later version, click on the "Comment" link at the right-hand side to view the Comments pane.4. You can then select any text and mark it up for deletion or replacement, or insert new text as needed. Please note that these will clearly be displayed in the Comments pane and secondary annotation is not needed to draw attention to your corrections. If you need to include new sections of text, it is also possible to add a comment to the proofs. To do this, use the Sticky Note tool in the task bar. Please also see our FAQs here: http://journalauthors.tandf.co.uk/production/index.asp.5. Make sure that you save the file when you close the document before uploading it to CATS using the "Upload File" button on the online correction form. If you have more than one file, please zip them together and then upload the zip file.If you prefer, you can make your corrections using the CATS online correction form.

Retrospective Study of Patients With SJS/TEN Treated at a Tertiary Burn Unit in Canada: Overview of 17 Years of Treatment

“…The overall mortality rate in our study, 21%, is comparable to those of other retrospective studies 14 during hospitalization. Although those who passed away during hospitalization were all from the first time period studied, our small sample size limits us in any meaningful conclusions between the reasons for the mortality difference between the 2 time periods.…”

“…Our most common offending medications were similar to those of other retrospective studies, with the most common being allopurinol, carbamazepine, cephalosporins, and trimethoprim-sulfamethoxazole. [14][15][16]19 The overall mortality rate in our study, 21%, is comparable to those of other retrospective studies 14 during hospitalization. Although those who passed away during hospitalization were all from the first time period studied, our small sample size limits us in any meaningful conclusions between the reasons for the mortality difference between the 2 time periods.…”

“…The most common causes of death were multiorgan failure and sepsis, also commonly found in other studies. 14,15,19 The fact that of the patient's who passed away, 100% had oral involvement, 89% ocular involvement, 67% had genital involvement in comparison to the overall percentages of 84% (oral), 79% (ocular), and 60% (genital) during hospitalization reinforces the necessity of a multi-disciplinary care team for patients. This team includes dermatology, ophthalmology, and gynecology at the minimum, as well as other specialists as needed in order to identify patients at higher risk of death.…”

“…Our most common offending medications were similar to those of other retrospective studies, with the most common being allopurinol, carbamazepine, cephalosporins, and trimethoprim-sulfamethoxazole. 14 -19,19…”

“…Six retrospective studies were conducted on the treatment of SJS/TEN in the adult populations. Tran and Sidhu 14 from Australia conducted a retrospective review of 42 patients with 18 years duration that showed improvement in mortality in those treated with intravenous immunoglobulin (IVIG) versus steroids and supportive care. Zhang et al 15 conducted a 10-year retrospective review of 48 patients in the United States and found that there was not a statistically significant mortality benefit when comparing the treatment of IVIG versus cyclosporine.…”