Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature

Letko, Erik; Papaliodis, Dean N.; Papaliodis, George N.; Daoud, Yassine J.; Ahmed, A. Razzaque; Foster, C. Stephen

doi:10.1016/s1081-1206(10)61112-x

Cited by 286 publications

(238 citation statements)

References 165 publications

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“…For phenytoin, carbamazepine and barbiturates, the incidence of DRESS has been estimated to one reaction per 5000 to 10 000 exposures. 2 Another factor affecting the frequency of hypersensitivity drug reactions is the route of drug administration; 6 topical, intramuscular and intravenous administrations are more likely to cause hypersensitivity reactions, as drugs are directly presented to the skin. Oral medications in general are less likely to result in drug hypersensitivity.…”

Section: Drug Reaction With Eosinophilia and Systemic Symptomsmentioning

confidence: 99%

Untitled

2006

Prescriber

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Section: Drug Reaction With Eosinophilia and Systemic Symptomsmentioning

confidence: 99%

Untitled

2006

Prescriber

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“…1,2 Among the drugs, implicated more often are allopurinol, antibiotics, anticonvulsants, and nonsteroid anti-inflammatories. 3 In addition to medications, conditions such as malignancies, systemic lupus erythematosus, viral infections, exposure to ultraviolet rays may trigger SJS/TEN.…”

Section: Introductionmentioning

confidence: 99%

Nimesulide induced toxic epidermal necrolysis: a rare case report

Kumar

Gari

Chakraborty

et al. 2017

Int J Basic Clin Pharmacol

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Adverse drug reactions to the prescribed medicines are the major obstacles in continuation of drug treatment. Nimesulide, a selective cyclo-oxygenase (COX-2) inhibitor was first launched in Italy in 1985 and subsequently marketed in more than 50 countries including India. Due to its better and faster antipyretic action, it has gained popularity among physicians and paediatricians. Here, we report a case of 60 years old male patient who developed toxic epidermal necrolysis (TEN) following ingestion of tablet nimesulide. The patient was managed with parenteral corticosteroids, antibiotics, emollients, anti-fungal and supportive care. This case highlights the importance of nimesulide and other NSAIDs as possible cause of TEN. Nimesulide has never been approved in countries like USA, Canada, Britain, New Zealand, Australia. But in India it is available as over the counter drug and is used for various indications like fever, myalgia, arthralgia. Therefore, the drugs which are banned outside India should be used with caution and medical practitioners should report all the adverse drug reactions to such drugs.

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“…SJS is a severe hypersensitive reaction that can be precipitated by infection, vaccination, systemic diseases, physical agents, foods and drugs [1]. The drugs that cause SJS commonly are antibacterials (sulfonamides), anticonvulsants (phenytoin, phenobarbital and carbamazepine), NSAIDs (oxicam derivatives) and oxide inhibitors (allopurinol) [2]. This syndrome may present as a nonspecific febrile illness (malaise, headache, cough, rhinorrhea) with oral and perioral involvement, polymorphic lesions of skin and mucous membrane characterized by acute blisters and erosions.…”

Section: Introductionmentioning

confidence: 99%