Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis – A Comprehensive Review and Guide to Therapy. I. Systemic Disease

Kohanim, Sahar; Palioura, Sotiria; Saeed, Hajirah N.; Akpek, Esen K.; Amescua, Guillermo; Basu, Sayan; Blomquist, Preston H.; Bouchard, Charles S.; Dart, John; Gai, Xiaowu; Gomes, José Álvaro Pereira; Gregory, Darren G.; Iyer, Geetha; Jacobs, Deborah S.; Johnson, Anthony J.; Kinoshita, Shigeru; Mantagos, Iason S.; Mehta, Jodhbir S.; Pérez, Víctor L.; Pflugfelder, Stephen C.; Sangwan, Veena; Sippel, Kimberly C.; Sotozono, Chie; Srinivasan, Bhaskar; Tan, Donald; Tandon, Radhika; Tseng, Scheffer C.G.; Ueta, Mayumi; Chodosh, James

doi:10.1016/j.jtos.2015.10.002

Cited by 124 publications

(116 citation statements)

References 220 publications

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“…The essential care giving [6,7] includes; 1) specific treatments such as steroid medication, Human Intravenous Immune Globulin (IVIG) medication, plasmapheres is treatment, etc. ; 2) supportive care to control complications by isolating the patient in specific care units such as Burn unit or ICU for infection prevention, osmoregulation, nutrition management, pain management, mental and spiritual care for patients and their families; and finally, 3) wound management.…”

Section: Discussionmentioning

confidence: 99%

“…Scoring 0-7 of the risk factors on SCORTEN scale signifies 1%, 4%, 12%, 32%, 62%, 85%, 85% 95% and 99% mortality rate respectively [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The goal of wound care is prevention of further mechanical trauma to the skin and management of wound infection [7,8]. Bacterial proliferation on the wound surface can lead to an invasive infection [4].…”

Section: Introductionmentioning

confidence: 99%

“…One should manage exudate, prevent maceration, and prevent further wound trauma to the patient. Medication management [7] includes immunosuppressive therapy using cyclosporine A, while Corticosteroid therapy is not recommended.…”

Section: Introductionmentioning

confidence: 99%

“…Examples of modern medical [3, [6][7][8] supplies used are paraffin-coated mesh, vaseline, petroleum, disinfectant dressings with silver-compounds such as nanocrystaline silver dressing, silver hydrofiber, silicone silver foam dressing etc. This makes wound care an expensive proposition and every effort in cost reduction and decreased pain level is welcomed.…”

Section: Introductionmentioning

confidence: 99%

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Wound Management of Patients with Toxic Epidermal Necrolysis Using Banana Leaf: A Case Study

Uppanisakorn¹,

Boonyarat²

2017

Adv Practice Nurs

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The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening allergic reactions to medication. They require immediate treatment with the primary goal to prevent infection and encourage healing. This research proposes a specific treatment and care for SJS/TEN patient using sterile banana leaf dressing, which allows the patient to be discharged swiftly and reduces the cost of treatment by 8 times. In conclusion, the case study where specific, supportive therapy using sterilized banana leaf dressing was given the patient can be discharged within 12 days.

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Section: Discussionmentioning

confidence: 99%

“…Scoring 0-7 of the risk factors on SCORTEN scale signifies 1%, 4%, 12%, 32%, 62%, 85%, 85% 95% and 99% mortality rate respectively [6,7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Wound Management of Patients with Toxic Epidermal Necrolysis Using Banana Leaf: A Case Study

Uppanisakorn¹,

Boonyarat²

2017

Adv Practice Nurs

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Bilateral Limbus-Sparing Conjunctivitis in a Boy With Rash and Pneumonia

2019

Self Cite

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An adolescent boy presented to the hospital with bilateral eye redness, an erythematous chest rash, lip blistering, and worsening sore throat for 2 days while undergoing a 10-day outpatient treatment course of ciprofloxacin and trimethoprim-sulfamethoxazole for community-acquired pneumonia. He complained of a cough, sore throat, and ocular itching. He denied prior ocular history and reported no visual changes. He had no significant medical history aside from documented allergies to β-lactam, macrolide, and cephalosporin antibiotics resulting in rashes, angioedema, and hives.The patient was febrile on admission, and results from chest radiography were consistent with pneumonia. Bedside ophthalmic examination revealed bilateral limbus-sparing conjunctival hyperemia that blanched minimally with phenylephrine, bilateral nasal and temporal conjunctival epithelial ulcerations, and inferior forniceal pseudomembranes (Figure , A). There were no symblephara or eyelid margin defects. Examination of the face revealed erosions with hemorrhagic crusts on the lip mucosa (Figure , B) but no associated cutaneous lesions or desquamation. Findings from the remainder of the ophthalmologic examination, including visual acuity, intraocular pressure, and dilated fundus examination, were unremarkable. Mycoplasma pneumoniae IgG and IgM titers were obtained and found to be within normal limits.

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Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

Langley

Worley

Pardo

et al. 2018

Cochrane Database of Systematic Reviews

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Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis – A Comprehensive Review and Guide to Therapy. I. Systemic Disease

Cited by 124 publications

References 220 publications

Wound Management of Patients with Toxic Epidermal Necrolysis Using Banana Leaf: A Case Study

Wound Management of Patients with Toxic Epidermal Necrolysis Using Banana Leaf: A Case Study

Bilateral Limbus-Sparing Conjunctivitis in a Boy With Rash and Pneumonia

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

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