Stevens Johnson Syndrome Triggered by Carbamazepine

Samali, Mehdi; Koundi, Abdelghafour El; Andaloussi, Mohammed Rabi; Meskine, Amine; Doghmi, Noufel; Bensghir, Mustapha

doi:10.36347/sjmcr.2022.v10i06.026

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a 22-yearold woman with a history of seizures, levetiracetam administered in combination with carbamazepine enhanced the incidence of SJS, characterized by vesicles and erythematous papules. The condition improved following administration of levetiracetam, and carbamazepine was discontinued [16]. SJS mediated by carbamazepine can also arise in people with no history of seizures but who complain of bipolar syndromelike symptoms.…”

Section: Discussionmentioning

confidence: 99%

The Co-Existence of Agranulocytosis and Stevens-Johnson Syndrome (SJS) in Carbamazepine Therapy: A Case Report

Batool¹,

Voloshyna²,

Usama³

et al. 2022

Cureus

View full text Add to dashboard Cite

The therapeutic significance of carbamazepine in individuals with trigeminal neuralgia, epilepsy, and bipolar disorder is well recognized. Although it has high effectiveness, it raises the patient's risk for some adverse effects. The relationship between carbamazepine usage and agranulocytosis is well-established. Agranulocytosis is characterized by an unusually low number of neutrophils. This disorder poses a grave hazard to the patient since they are more likely to get potentially lethal bacterial or fungal infections. Moreover, carbamazepine is one of the most common causes of Stevens-Johnson syndrome (SJS), a severe skin condition with a high mortality rate. In cases where agranulocytosis and Stevens-Johnson syndrome coexist, the prognosis is relatively poor. We report a rare case of a patient who developed agranulocytosis and Stevens-Johnson syndrome after taking carbamazepine. Neutrophils accounted for 2.1% of the patient's differential leukocyte count. Furthermore, Naranjo's scale found a score of 8 for Stevens-Johnson syndrome, placing it in the "probable" category, while a score of 9 for agranulocytosis indicated that it was a confirmed adverse reaction to carbamazepine.

show abstract

Section: Discussionmentioning

confidence: 99%