Stevens-Johnson syndrome triggered by Levetiracetam—Caution for use with Carbamazepine

Sawal, Nishit; Kanga, Uma; Shukla, Garima; Goyal, Vinay; Srivastava, Achal Kumar

doi:10.1016/j.seizure.2020.06.004

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…In a 22-year-old woman with a history of seizures, levetiracetam administered in combination with carbamazepine enhanced the incidence of SJS, characterized by vesicles and erythematous papules. The condition improved following administration of levetiracetam, and carbamazepine was discontinued [ 16 ]. SJS mediated by carbamazepine can also arise in people with no history of seizures but who complain of bipolar syndrome-like symptoms.…”

Section: Discussionmentioning

confidence: 99%

The Co-Existence of Agranulocytosis and Stevens-Johnson Syndrome (SJS) in Carbamazepine Therapy: A Case Report

Batool¹,

Voloshyna²,

Usama³

et al. 2022

Cureus

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The therapeutic significance of carbamazepine in individuals with trigeminal neuralgia, epilepsy, and bipolar disorder is well recognized. Although it has high effectiveness, it raises the patient's risk for some adverse effects. The relationship between carbamazepine usage and agranulocytosis is well-established. Agranulocytosis is characterized by an unusually low number of neutrophils. This disorder poses a grave hazard to the patient since they are more likely to get potentially lethal bacterial or fungal infections. Moreover, carbamazepine is one of the most common causes of Stevens-Johnson syndrome (SJS), a severe skin condition with a high mortality rate. In cases where agranulocytosis and Stevens-Johnson syndrome coexist, the prognosis is relatively poor. We report a rare case of a patient who developed agranulocytosis and Stevens-Johnson syndrome after taking carbamazepine. Neutrophils accounted for 2.1% of the patient's differential leukocyte count. Furthermore, Naranjo's scale found a score of 8 for Stevens-Johnson syndrome, placing it in the "probable" category, while a score of 9 for agranulocytosis indicated that it was a confirmed adverse reaction to carbamazepine.

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Section: Discussionmentioning

confidence: 99%

The Co-Existence of Agranulocytosis and Stevens-Johnson Syndrome (SJS) in Carbamazepine Therapy: A Case Report

Batool¹,

Voloshyna²,

Usama³

et al. 2022

Cureus

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“…They are also used in genetic screening e.g. HLA-B*57:01 in Caucasian population for abacavir hypersensitivity, HLA-B*15:02 in Chinese and Asians for carbamazepine induced life-threatening conditions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) [9,29]. In the context of transplantation, mismatch of HLA alleles between donor and recipient impacts the solid organ and hematopoietic stem cell transplantation outcomes [3,26].…”

Section: Introductionmentioning

confidence: 99%

HLA-SPREAD: a natural language processing based resource for curating HLA association from PubMed abstracts

et al. 2022

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Extreme complexity in the Human Leukocyte Antigens (HLA) system and its nomenclature makes it difficult to interpret and integrate relevant information for HLA associations with diseases, Adverse Drug Reactions (ADR) and Transplantation. PubMed search displays ~ 146,000 studies on HLA reported from diverse locations. Currently, IPD-IMGT/HLA (Robinson et al., Nucleic Acids Research 48:D948–D955, 2019) database houses data on 28,320 HLA alleles. We developed an automated pipeline with a unified graphical user interface HLA-SPREAD that provides a structured information on SNPs, Populations, REsources, ADRs and Diseases information. Information on HLA was extracted from ~ 28 million PubMed abstracts extracted using Natural Language Processing (NLP). Python scripts were used to mine and curate information on diseases, filter false positives and categorize to 24 tree hierarchical groups and named Entity Recognition (NER) algorithms followed by semantic analysis to infer HLA association(s). This resource from 109 countries and 40 ethnic groups provides interesting insights on: markers associated with allelic/haplotypic association in autoimmune, cancer, viral and skin diseases, transplantation outcome and ADRs for hypersensitivity. Summary information on clinically relevant biomarkers related to HLA disease associations with mapped susceptible/risk alleles are readily retrievable from HLASPREAD. The resource is available at URL http://hla-spread.igib.res.in/. This resource is first of its kind that can help uncover novel patterns in HLA gene-disease associations.

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“…They are also used in genetic screening e.g. HLA-B*57:01 in Caucasian population for abacavir hypersensitivity, HLA-B*15:02 in Chinese and Asians for carbamazepine induced life-threatening conditions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) and also for SJS due to carbamazepine and other drug combinations (9,10). In the context of transplantation, mismatch of HLA alleles between donor and recipient impacts the solid organ and hematopoietic stem cell transplantation outcomes (11).…”

Section: Introductionmentioning

confidence: 99%

HLA-SPREAD: A Natural Language Processing based resource for curating HLA association from PubMed abstracts

Dholakia

Kalra

Misir

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Extreme complexity in the HLA system and its nomenclature makes it difficult to interpret and integrate relevant information for HLA associations with diseases, Adverse Drug Reactions (ADR), Transplantation. PubMed search displays ~110,000 studies on Human Leukocyte Antigens (HLA) reported from, diverse locations and on multiple populations and IPD-IMGT/HLA database houses data on 28,320 HLA alleles till date. We developed an automated pipeline with a unified graphical user interface HLA-SPREAD that provides a structured information on SNPs, Populations, REsources, ADRs and Diseases information. Information on HLA was extracted from ~24 million PubMed abstracts extracted using Natural Language Processing (NLP). Python scripts were used to mine and curate information on diseases, filter false positives and categorize to 24 tree hierarchical groups and named Entity Recognition (NER) algorithms and semantic analysis to infer HLA association(s). This resource from 116 countries and 47 ethnic groups provides interesting insights on: markers associated with allelic/haplotypic association in autoimmune, cancer, viral and skin diseases, transplantation outcome and ADRs for hypersensitivity. Summary information on clinically relevant biomarkers related to HLA disease associations with mapped susceptible/risk alleles are readily retrievable from HLASPREAD. This resource is first of its kind that can help uncover novel patterns in HLA gene-disease associations.

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Stevens-Johnson syndrome triggered by Levetiracetam—Caution for use with Carbamazepine

Cited by 6 publications

References 7 publications

The Co-Existence of Agranulocytosis and Stevens-Johnson Syndrome (SJS) in Carbamazepine Therapy: A Case Report

The Co-Existence of Agranulocytosis and Stevens-Johnson Syndrome (SJS) in Carbamazepine Therapy: A Case Report

HLA-SPREAD: a natural language processing based resource for curating HLA association from PubMed abstracts

HLA-SPREAD: A Natural Language Processing based resource for curating HLA association from PubMed abstracts

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