Stevensjohnson Syndrome Caused by a Health Drink (Eberu®) Containing Ophiopogonis Tuber

Mochitomi, Yuji; Inoue, Akiyo; Kawabata, Hideyuki; Ishida, Susumu; Kanzaki, Tamotsu

doi:10.1111/j.1346-8138.1998.tb02477.x

Cited by 26 publications

(23 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A 66-year old Japanese woman had self-medicated this remedy and subsequently fell acutely ill [20]. She developed StevensJohnson syndrome, a severe type of erythema exsudativum, with bullous and eroded skin lesions over her entire body as well as liver dysfunction.…”

Section: Ophiopogon Japonicus (Mai-meue-dong-tang)mentioning

confidence: 99%

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Ernst

2002

AGE

View full text Add to dashboard Cite

Unconventional therapies are increasingly popular, not least in populations of elderly individuals. This review summarizes the evidence regarding the risk unconventional therapies may entail for the elderly. Computerized literature searches were performed to locate all reports with original data on this topic. Most of the evidence found was anecdotal by nature and thus has obvious limitations. The results show that elderly patients can suffer harm from unconventional therapies. Herbal treatments are associated most frequently with adverse events. They can cause both direct toxicity and unwanted herb-drug interactions. Acupuncture, spinal manipulation and even massage therapy have also been implicated. Indirect risks exist if unconventional therapies are employed as a substitute for conventional treatments. It is concluded that unconventional therapies are not risk-free for elderly patients. All parties involved ought to be educated with a view of minimizing this risk, and more research is needed to increase our understanding of this area.

show abstract

Section: Ophiopogon Japonicus (Mai-meue-dong-tang)mentioning

confidence: 99%

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Ernst

2002

AGE

View full text Add to dashboard Cite

show abstract

“…48 It has also occurred in patients who have ingested ''natural medications'' and traditional Chinese herbal medications. [49][50][51] Pseudoephedrine, a common ingredient in over-the-counter cold remedies and decongestants, can cause TEN. 52 The period of greatest risk for developing SJS/TEN is in the first two months of treatment.…”

Section: Clinical Aspects Of Sjs/tenmentioning

confidence: 99%

Toxic epidermal necrolysis

Pereira

Mudgil

Rosmarin

2007

Journal of the American Academy of Dermatology

287

237

View full text Add to dashboard Cite

“…DISCUSSION DT-13 exerts a wide spectrum of physiological and pharmacological activities. 20) The beneficial effects of DT-13 on tumors 11) and other systems, such as in the cardiovascular 21) and immune systems 22) have been extensively investigated. However, studies on the effect of DT-13 on cancer metastases are rare.…”

Section: Effects Of Dt-13 On Egr-1 In Human Breast Cancer Cells Undermentioning

confidence: 99%

The Saponin Monomer of Dwarf Lilyturf Tuber, DT-13, Reduces Human Breast Cancer Cell Adhesion and Migration during Hypoxia via Regulation of Tissue Factor

Sun

Lin

Zhao

et al. 2010

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

In 2009, the most commonly diagnosed type of cancer among women in the United States was breast cancer, accounting for 27% (192370) of all new cancer cases.1) Despite improvements in detecting and treating the primary tumor, long-term survival is often compromised by the appearance of metastatic lesions in unrelated tissues such as the brain or bone.2) The metastatic dissemination of tumor cells requires the acquisition of biological properties including enhanced migratory behavior and the capacity to breach blood vessel walls and the dense collagenous matrix surrounding tumors.3,4) Currently, there is no effective therapy for this cancer in the advanced stages after metastasis, and new approaches are urgently needed to treat such a malignant disease.Hypoxia is an important factor that promotes cancer metastasis. 5,6) In contrast to established cell lines cultured under normal oxygen concentrations, tumors in the body grow under a specific internal environment characterized by much lower oxygen concentrations. Tissue factor (TF) is frequently over-expressed in human tumors and exhibits dual influences through its signaling and procoagulant activity. 7)In some cases, tumor cells were found to ectopically produce the main TF ligand, plasma protein factor VII, an observation that may suggest a cancer-specific 'autocrine' activation of the TF pathway.7) These new observations of TF suggest this unique molecule can be exploited in various ways to treat human cancer. As it is functionally involved in tumor initiation, growth and angiogenesis, TF could be a rational target for the development of agents to specifically kill tumor cells or block metastasis.8) Overall, several new findings related to TF create a fascinating prospect that this unique molecule could be explored in various ways to treat human cancer.Dwarf lilyturf tuber, a traditional Chinese medicinal (TCM) plant, is used widely in the clinics.9) The saponin monomer 13 of dwarf lilyturf tuber (DT-13), one of the saponin monomers of dwarf lilyturf tuber isolated from Ophiopogon japonicus (THUNB.) ker-Gaul, 9,10) has been found to exhibit anti-tumor effects.11) However, direct evidence for the mechanism of action of DT-13 on tumors during hypoxia is lacking. Interestingly, in our preliminary experiments, we found that DT-13 could inhibit hypoxia-induced adhesion of cancer cells. Thus, the purpose of this present study was to investigate the effects of DT-13 on human breast carcinoma metastasis in hypoxic conditions, and explore the possible mechanism of DT-13 against tumor metastases. MATERIALS AND METHODS Cell Lines and Cell CultureHuman breast carcinoma MDA-MB-435 cells were cultured as monolayers in Dulbecco's modified Eagle's medium media (DMEM, Gibco) supplemented with 10% fetal calf serum (FCS, Gibco), 100 U/ml penicillin and 100 mg/ml streptomycin. To create hypoxic conditions, 70-80% confluent cells were placed in an anaerobic chamber (HERAcell 150, Thermo) with 1% O 2 and 5% CO 2 at 37°C.Cytotoxicity Assays Inhibitory effects were determined using t...

show abstract

Stevensjohnson Syndrome Caused by a Health Drink (Eberu®) Containing Ophiopogonis Tuber

Cited by 26 publications

References 3 publications

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Adverse effects of unconventional therapies in the elderly: A systematic review of the recent literature

Toxic epidermal necrolysis

The Saponin Monomer of Dwarf Lilyturf Tuber, DT-13, Reduces Human Breast Cancer Cell Adhesion and Migration during Hypoxia via Regulation of Tissue Factor

Contact Info

Product

Resources

About