Stevia Eupatoria and Stevia Pilosa Extracts Inhibit the Proliferation and Migration of Prostate Cancer Cells

Martínez-Rojo, Elizabeth; Cariño-Cortés, Raquel; Berumen, Laura C.; Garcı́a-Alcocer, Guadalupe; Escobar-Cabrera, Jesica

doi:10.3390/medicina56020090

Cited by 9 publications

(11 citation statements)

References 33 publications

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“…A clinical trial that will analyze 75 approved anticancer agents for urothelial cancer, enlisting abiraterone, will provide more information on the efficacy of these agents in bladder cancer treatment [ 124 ]. Research is still lacking for small molecules that ortho- or allosterically interact with androgen receptors [ 125 , 126 ], as several other AR-targeted new drugs need to be investigated (such as RNA-based therapies), most of them for prostate cancer, although bladder cancer might also benefit from these [ 127 ].…”

Section: Bladder Cancer Therapiesmentioning

confidence: 99%

The Role of Androgens and Androgen Receptor in Human Bladder Cancer

et al. 2021

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Bladder cancer (urothelial carcinoma) is one of the most frequently diagnosed neoplasms, with an estimated half a million new cases and 200,000 deaths per year worldwide. This pathology mainly affects men. Men have a higher risk (4:1) of developing bladder cancer than women. Cigarette smoking and exposure to chemicals such as aromatic amines, and aniline dyes have been established as risk factors for bladder cancer and may contribute to the sex disparity. Male internal genitalia, including the urothelium and prostate, are derived from urothelial sinus endoderm; both tissues express the androgen receptor (AR). Several investigations have shown evidence that the AR plays an important role in the initiation and development of different types of cancer including bladder cancer. In this article, we summarize the available data that help to explain the role of the AR in the development and progression of bladder cancer, as well as the therapies used for its treatment.

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Section: Bladder Cancer Therapiesmentioning

confidence: 99%

The Role of Androgens and Androgen Receptor in Human Bladder Cancer

et al. 2021

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“…The researchers used the wound-healing assay in order to evaluate the migratory capacity of androgen-dependent and androgen-independent prostate cell lines (LNCaP and PC-3, respectively) after 24, 48 and 72 h. Both extracts were not cytotoxic in human fibroblasts in concentrations under 1000 µg/mL, whereas they significantly reduced the viability of prostate cancer cells in all concentrations used (250-3000 µg/mL), suggesting that they may be a potential source of molecules for the treatment of cancer. Treatment with stevia extracts in combination with enzalutamide resulted in greater inhibition of the proliferation and migration of prostate cancer cells compared to the extracts alone, but not compared to enzalutamide alone [68].…”

Section: Antitumor Effects Of Stevia Rebaudiana Derivatives In Other ...mentioning

confidence: 84%

“…We also found a recent study on the effects of Stevia pilosa and Stevia eupatoria on cancer cell proliferation and migration with interesting results that are worth reporting. In this study, the effects of a Stevia pilosa and a Stevia eupatoria methanolic root extract (SPME and SEME, respectively) were evaluated alone, as well as in combination with enzalutamide, on the cell viability and migration of prostate cancer cells [68]. Enzalutamide, an inhibitor of the androgen receptor pathway, has been approved as a hormonal therapy for castration-resistant prostate cancer [69].…”

Section: Antitumor Effects Of Stevia Rebaudiana Derivatives In Other ...mentioning

confidence: 99%

Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener

et al. 2022

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Stevia rebaudiana Bertoni is a perennial shrub from Paraguay that is nowadays widely cultivated, since it is increasingly being utilized as a sugar substitute in various foodstuffs due to its sweetness and minimal caloric content. These properties of the plant’s derivatives have spurred research on their biological activities revealing a multitude of benefits to human health, including antidiabetic, anticariogenic, antioxidant, hypotensive, antihypertensive, antimicrobial, anti-inflammatory and antitumor actions. To our knowledge, no recent reviews have surveyed and reported published work solely on the latter. Consequently, our main objective was to present a concise, literature-based review of the biological actions of stevia derivatives in various tumor types, as studied in in vitro and in vivo models of the disease. With global cancer estimates suggesting a 47% increase in cancer cases by 2040 compared to 2020, the data reviewed in this article should provide a better insight into Stevia rebaudiana and its products as a means of cancer prevention and therapy within the context of a healthy diet.

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“…To our knowledge and until the time of writing this manuscript, this is the first study to address the role of steviol glycosides from Stevia rebaudiana plant, in breast cancer cell migration. The only available information regarding cell migration comes from Stevia eupatoria and Stevia pilosa plants, whom methanolic extracts reduced the migratory potential of PC‐3 prostate cancer cells 32 …”

Section: Discussionmentioning

confidence: 99%

Steviol glycosides affect functional properties and macromolecular expression of breast cancer cells

2022

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Steviol glycosides, the active sweet components of stevia plant, have been recently found to possess a number of therapeutic properties, including some recorded anticancer ones against various cancer cell types (breast, ovarian, cervical, pancreatic, and colon cancer). Our aim was to investigate this anticancer potential on the two most commonly used breast cancer cell lines which differ in the phenotype and estrogen receptor (ER) status: the low metastatic, ERα+ MCF-7 and the highly metastatic, ERαÀ/ERβ+ MDA-MB-231. Specifically, glycosides' effect was studied on cancer cells': (a) viability, (b) functionality (proliferation, migration, and adhesion), and (c) gene expression (mRNA level) of crucial molecules implicated in cancer's pathophysiology. Results showed that steviol glycosides induced cell death in both cell lines, in the first 24 hr, which was in line with the antiapoptotic BCL2 decrease. However, cells that managed to survive showcased diametrically opposite behavior. The low metastatic ERα+ MCF-7 cells acquired an aggressive phenotype, depicted by the upregulation of all receptors and co-receptors (ESR, PGR, AR, GPER1, EGFR, IGF1R, CD44, SDC2, and SDC4), as well as VIM and MMP14. On the contrary, the highly metastatic ERαÀ/ERβ+ MDA-MB-231 cells became less aggressive as pointed out by the respective downregulation of EGFR, IGF1R, CD44, and SDC2. Changes observed in gene expression were compatible with altered cell functions. Glycosides increased MCF-7 cells migration and adhesion, but reduced MDA-MB-231 cells migratory and metastatic potential. In conclusion, the above data clearly demonstrate that steviol glycosides have different effects on breast cancer cells according to their ER status, suggesting that steviol glycosides might be examined for their potential anticancer activity against breast cancer, especially triple negative breast cancer (TNBC).

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Stevia Eupatoria and Stevia Pilosa Extracts Inhibit the Proliferation and Migration of Prostate Cancer Cells

Cited by 9 publications

References 33 publications

The Role of Androgens and Androgen Receptor in Human Bladder Cancer

The Role of Androgens and Androgen Receptor in Human Bladder Cancer

Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener

Steviol glycosides affect functional properties and macromolecular expression of breast cancer cells

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