Stevia Genus: Phytochemistry and Biological Activities Update

Borgo, Jimena; Laurella, Laura C.; Martini, Florencia; Catalán, César A.N.; Sülsen, Valeria P.

doi:10.3390/molecules26092733

Cited by 21 publications

(13 citation statements)

References 262 publications

(300 reference statements)

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“…In particular, the chemical composition of S. aristata was published by Zdero et al [46] in which beyerene derivatives and other terpenoids were reported. In vitro antiparasitic efficacy has been described for many compounds belonging to these groups [13,[47][48][49]. Interestingly, the effect of the sesquiterpene lactone eupatoriopicrin was determined on an in vivo model of T. cruzi infection [50].…”

Section: Discussionmentioning

confidence: 99%

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Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Albani

Borgo

Fabbri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cystic echinococcosis is a zoonotic disease caused by the parasite Echinococcus granulosus sensu lato (s.l.), which is worldwide distributed and causes long-lasting infections in animals and humans. The existing treatment is limited to the use of benzimidazoles, mainly albendazole (ABZ). However, it has unwanted side effects and its efficacy is about 50%. The Asteraceae family includes plants that have therapeutic applications (medicinal species) and has an important role in new drug development. The species belonging to a different genus of this family show a wide range of anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, and antiparasitic activities, among others. The aim of the present study was to evaluate the in vitro efficacy of extracts of four Asteraceae species against protoscoleces of E. granulosus sensu stricto (s.s.). On the other hand, the Stevia aristata extract was assessed on the murine cyst of E. granulosus (s.s.) and the efficacy of S. aristata extract was investigated in a murine model of CE. Stevia satureiifolia, S. aristata, Grindelia pulchella, and G. chiloensis extracts at 100 μg/mL caused a decrease in protoscoleces viability; however, S. aristata extract produced the greatest in vitro protoscolicidal effect. After 20 days of treatment with the highest concentration (100 μg/mL) of S. aristata extract, protoscoleces viability decreased to 0%. The tegumental changes observed by scanning electron microscopy were consistent with the reduction in vitality. The collapse of the germinal layer was registered in 60 ± 5.8% and 83.3 ± 12.0% of cysts treated during 4 days with 50 and 100 μg/ml, respectively. The half maximal effective concentration (EC50) value of the S. aristata extract against E. granulosus (s.s.) cysts was 47.86 μg/mL (96 h). The dosage of infected animals with the 50 mg kg−1 dose of S. aristata extract resulted in a significant reduction in cyst weight in comparison with the control group. In conclusion, S. aristata extract was demonstrated to exert a marked effect, both in vitro and in the murine model.

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Section: Discussionmentioning

confidence: 99%

“…Extracts and isolated compounds from the Stevia species have been shown to have a variety of biological activities. The majority of them have antioxidant, antiparasitic, antiviral, anti-inflammatory, and antiproliferative properties [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Albani

Borgo

Fabbri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Stevia genus is characterized by the presence of sesquiterpene lactones, diterpenoids and flavonoids, among other phytochemical groups (Borgo et al ., 2021). Anti-parasitic activity has been described for many compounds belonging to these groups (Sanchez Alberti et al ., 2018; Boniface and Ferreira, 2019; Sessa et al ., 2020; Sülsen, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Plants from the Stevia genus (Asteraceae) are a potential source of anti-protozoal and anti-microbial compounds (Ruiz-Ruiz et al ., 2017; Borgo et al ., 2021). Recently, it has been shown that dichloromethane extracts of Stevia species presented a significant activity on Trypanosoma cruzi epimastigotes (Beer et al ., 2016).…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic activity ofStevia multiaristataextract againstEchinococcus granulosus sensu stricto

et al. 2021

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Cystic echinococcosis is a zoonotic disease caused by the larval stage of the parasite Echinococcus granulosus sensu lato. The available anti-parasitic treatment is mostly limited to a continuous administration of albendazole. However, due to its numerous side-effects and efficacy of around 50%, there is a need to find new drugs to improve the treatment for this disease. In the current study, the in vitro and in vivo efficacy of a Stevia multiaristata extract against E. granulosus sensu stricto (s.s.) was demonstrated. Stevia multiaristata extract (100 and 50 μg mL−1) caused a quick viability decrease on protoscoleces which was consistent with the observed tegumental alterations. Loss of turgidity was detected in 95 ± 3.4% of cysts incubated with S. multiaristata extract during 2 days (100 μg mL−1) and the collapse of the germinal layer was observed in 60 ± 9.3% of cysts treated with 100 μg mL−1 of the S. multiaristata extract during 4 days. The half maximal effective concentration value was 69.6 μg mL−1 and the selectivity index for E. granulosus s.s. cysts was 1.9. In this clinical efficacy study, the treatment of infected mice with the S. multiaristata extract (50 mg kg−1) caused a significant decrease in the weight of the cysts compared with the control group. These results coincided with the tissue damage observed in the cysts at the ultrastructural level. In conclusion, we observed high protoscolicidal and cysticidal effects, and significant reduction in the weight of the cysts in experimentally infected mice following treatment with the S. multiaristata extract.

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“…Estafiatin 1 is a major characteristic terpenoid component of Achillea nobilis L. and Stevia alpina Griseb [ 5 , 6 , 7 , 8 ]. Achillea nobilis L. is considered renewable plant raw material that has a sustainable operational reserve, which makes it possible to obtain the biologically active sesquiterpene lactone estafiatin on an industrial scale.…”

Section: Introductionmentioning

confidence: 99%

Syntheses Based on 3,4α-Epoxy-1,5,7α,6β(H)-guai-10(14),11(13)-dien-6,12-olide

Адекенов¹

2022

Molecules

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The sesquiterpene γ-lactone estafiatin 1, the molecule of which has a structure of 3,4α-epoxy-1,5,7α,6β(H)-guai-10(14),11(13)-dien-6,12-olide, is characteristic of plants of the genera Achillea L. and Artemisia L. of the Asteraceae family. This article presents the results of chemical modification for three reaction centers of the estafiatin molecule 1: epoxy cycle, exomethylene group conjugated with γ-lactone carbonyl, and exomethylene group in position С10=С14; and at the same time 33 new derivatives were synthesized, the structures of which were established based on physicochemical constants, spectral data (IR-, PMR-, 13C-NMR), and X-ray diffraction analysis. The stereo- and regiospecificity, as well as the chemoselectivity of the reaction based on estafiatin molecule 1, are discussed. The reactivity of the substrate is significantly influenced by the stereochemistry of its molecule, the nature of the reagent, and the reaction medium. Based on the results of in silico screening, derivatives of estafiatin with high binding energies for both DNA-topoisomerase I and DNA-topoisomerase II were identified. The values of the inhibitory dose of IC50 for estafiatin 1 and its derivatives were determined on cell lines of eight types of tumors. In vivo experiments of the samples made it possible to establish that estafiatin 1 and its derivatives have pronounced antitumor activity against Pliss lymphosarcoma, Walker’s carcinosarcoma, sarcoma 45, sarcoma-180, alveolar liver cancer PC-1, leukemia P-388 and L-1210, and sarcoma-45 resistant to 5-fluorouracil.

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Stevia Genus: Phytochemistry and Biological Activities Update

Cited by 21 publications

References 262 publications

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s

Anthelmintic activity ofStevia multiaristataextract againstEchinococcus granulosus sensu stricto

Syntheses Based on 3,4α-Epoxy-1,5,7α,6β(H)-guai-10(14),11(13)-dien-6,12-olide

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