Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments

Hao, Shuang; Guthrie, Brian; Kim, Soo-Kyung; Balanda, Sergej; Kubicek, Jan; Murtaza, Babar; Khan, Naim A.; Khakbaz, Pouyan; Su, Judith; Goddard, William A.

doi:10.1038/s42004-024-01324-x

Commun Chem

2024

DOI: 10.1038/s42004-024-01324-x

|View full text |Cite

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments

Shuang Hao,

Brian Guthrie,

Soo-Kyung Kim

et al.

Help me understand this report

View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Whispering gallery mode optical resonators for biological and chemical detection: current practices, future perspectives, and challenges

Hao,

2024

Rep. Prog. Phys.

View full text Add to dashboard Cite

Sensors are important for a wide variety of applications include medical diagnostics and environmental monitoring. Due to their long photon confinement times, whispering gallery mode sensors are among the most sensitive sensors currently in existence. We briefly discuss what are whispering gallery mode sensors, the principles of whispering gallery mode sensing, and the history of the field, beginning with Mie theory. We discuss recent work in the field on using these whispering gallery mode resonators as sensors, focusing particularly on biological and chemical sensing applications. We discuss how sensorgrams are acquired and fundamental measurement limits. In addition, we discuss how to interpret binding curves and extract physical parameters such as binding affinity constants. We discuss the controversy surrounding single-molecule detection and discuss hybrid whispering gallery mode nanoparticle sensors. In addition, we place these sensors in context with others sensing technologies both labeled and label-free. Finally, we discuss what we believe are the most promising applications for these devices, outline remaining challenges, and provide an outlook for the future.

show abstract

Whispering gallery mode optical resonators for biological and chemical detection: current practices, future perspectives, and challenges

Hao,

2024

Rep. Prog. Phys.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments

Cited by 1 publication

References 112 publications

Whispering gallery mode optical resonators for biological and chemical detection: current practices, future perspectives, and challenges

Whispering gallery mode optical resonators for biological and chemical detection: current practices, future perspectives, and challenges

Contact Info

Product

Resources

About