Stewart–Treves syndrome—treatment and outcome in six patients from a single centre

Roy, Pratik; Clark, Matthew A.; Thomas, Jennifer

doi:10.1016/j.ejso.2004.07.027

Cited by 44 publications

(21 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Angiosarcoma, a highly vascular endothelial neoplasm, commonly arises de novo , but may also manifest as a secondary tumor subsequent to radiation therapy or in association with chronic lymphedema (for example Roy et al 2004). Both forms share grossly comparable clinical behavior and histomorphology (Billings et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

et al. 2014

View full text Add to dashboard Cite

Canine hemangiosarcoma is a highly aggressive vascular neoplasm associated with extensive clinical and anatomical heterogeneity and a grave prognosis. Comprehensive molecular characterization of hemangiosarcoma may identify novel therapeutic targets and advanced clinical management strategies, but there are no published reports of tumor-associated genome instability and disrupted gene dosage in this cancer. We performed genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds that are highly predisposed to this disease. The cohort exhibited limited global genomic instability, compared to other canine sarcomas studied to date, and DNA copy number aberrations (CNAs) were predominantly of low amplitude. Recurrent imbalances of several key cancer-associated genes were evident; however the global penetrance of any single CNA was low and no distinct hallmark aberrations were evident. Copy number gains of dog chromosomes 13, 24 and 31, and loss of chromosome 16, were the most recurrent CNAs involving large chromosome regions, but their relative distribution within and between cases suggests they most likely represent passenger aberrations. CNAs involving CDKN2A, VEGFA and the SKI oncogene were identified as potential driver aberrations of hemangiosarcoma development, highlighting potential targets for therapeutic modulation. CNA profiles were broadly conserved between the five breeds, although subregional variation was evident, including a near two-fold lower incidence of VEGFA gain in Golden Retrievers versus other breeds (22% versus 40%). These observations support prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly-distinct subtypes of canine hemangiosarcoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

et al. 2014

View full text Add to dashboard Cite

show abstract

“…These patients usually present with purplish, multicentric lesions in a lymphedematous extremity, often have aggressive disease, and are thought to carry a poor prognosis. Others have reported some long-term survival in small series [23].…”

Section: Cutaneous Angiosarcoma Associated With Radiation or Lymphedemamentioning

confidence: 98%

“…There have been about 300 cases of Steward-Treves syndrome reported world-wide [23]. These patients usually present with purplish, multicentric lesions in a lymphedematous extremity, often have aggressive disease, and are thought to carry a poor prognosis.…”

Section: Cutaneous Angiosarcoma Associated With Radiation or Lymphedemamentioning

confidence: 99%

Malignant tumors of blood vessels: Angiosarcomas, hemangioendotheliomas, and hemangioperictyomas

Koch

Nielsen

Yoon

2008

Journal of Surgical Oncology

104

112

View full text Add to dashboard Cite

Sarcomas that arise from or resemble the components of blood vessels are uncommon and include angiosarcomas, hemangioendotheliomas, and hemangiopericytomas. This article reviews the management of these three types of sarcomas. Diagnosis can sometimes be difficult, with the diagnosis of hemangiopericytoma versus solitary fibrous tumor currently in debate. Each of these sarcomas subtypes has certain unique clinical traits. The mainstay of treatment is surgical resection, sometimes combined with radiation therapy. Adjuvant chemotherapy is unproven but can be considered. For patients with advanced disease, various chemotherapeutic regimens may result in meaningful responses in a minority of patients.

show abstract

“…Angiosarcomas of the breast are very rare tumors with a poor prognosis, originating from endothelial cells. Angiosarcomas of the breast can develop as a primary or secondary malignancies or they can arise due to chronic lymphoedema of the upper extremity following mastectomy and radical dissection or radiotherapy of the axillary lymph nodes [11]. Primary angiosarcoma usually occurs in younger women, and often involves the breast parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Breast angiosarcoma one year after adenosquamous endometrial cancer — diagnostic pitfalls

et al. 2012

View full text Add to dashboard Cite

AbstractAngiosarcoma of the breast is a rare and very aggressive tumors originated from endothelial cells lining blood vessels. We report a case of a 55-year-old postmenopausal female with a primary breast angiosarcoma diagnosed just a one year after radical hysterectomy and radiation therapy due to endometrial cancer. The patient initially presented with postmenopausal bleeding. Cytology and biopsy of the endometrium were performed and endometrial adenosquamous carcinoma was diagnosed followed by radical hysterectomy and postoperative local radiatiotherapy (50 Gy). One year later patient presented with a great painful tumorous mass in the right breast. Physical examination revealed an oval tumor, located in upper and outer quadrant of the right breast, around 15 cm in diameter. Mammography and ultrasonography were performed. The angiosarcoma of the breast was confirmed by biopsy. The patient underwent radical mastectomy. Histopathology proved the diagnosis of angiosarcoma (high-grade, numerous mitoses over 10/10 HPF, necrosis, “blood lakes”, infiltrative borders). Differential diagnosis of a breast angiosarcoma should be considered in all painful breast tumours no mather the time and the location of the previous radiation treatment even if benign characteristics of these masses have been detected by mammography and breast ultrasound.

show abstract

Stewart–Treves syndrome—treatment and outcome in six patients from a single centre

Cited by 44 publications

References 17 publications

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

Malignant tumors of blood vessels: Angiosarcomas, hemangioendotheliomas, and hemangioperictyomas

Breast angiosarcoma one year after adenosquamous endometrial cancer — diagnostic pitfalls

Contact Info

Product

Resources

About