Stewart–Treves syndrome—treatment and outcome in six patients from a single centre

Abstract

Early diagnosis and treatment by radical ablative surgery confers a reasonable prognosis with this rare but aggressive disease. A nihilistic approach is unjustified.

The spectrum of rare morphological variants of cutaneous epithelioid angiosarcoma

“…The characteristic presentation as large violaceous nodules or plaques, either on the head and neck of elderly males or in the setting of previous radiotherapy or longstanding severe lymphoedema, is a further diagnostic clue. [2][3][4][5]12,17,18 The final diagnosis is, however, entirely dependent on the appropriate immunophenotype with expression of endothelial cell antigens.…”

“…It typically arises in three dis-tinctive clinical settings: (i) on sun-damaged skin of the elderly (conventional cutaneous angiosarcoma); (ii) at the site of previous radiation treatment (post-radiation cutaneous angiosarcoma); and (iii) in lymphoedematous limbs (lymphoedema-associated cutaneous angiosarcoma). [1][2][3][4][5] Conventional cutaneous angiosarcoma is the most common form, affecting sun-exposed skin of the elderly, with a male predilection. 4,6 Its clinical presentation is characterized by large erythematous to violaceous patches, plaques, or nodules, most commonly affecting the face and scalp.…”

Stewart-Treves syndrome: Pathogenesis and management

“…We and others advocate radical ablative surgery with an early diagnosis. 51,52 Even in cases of early surgical treatment, prognosis remains dismal, with a high rate of local recurrence and metastasis. Amputation of the limb or forequarter is preferred over wide local surgical excision.…”

Major Upper-Limb Amputations for Malignant Tumors

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Even in recurrent tumors, amputation is typically performed only when limb preservation is no longer possible. 15,16 One reason why major upper-limb amputations are avoided is that, unlike lower limb prostheses, upperlimb prostheses are inadequate aesthetic and functional substitutes for the native limbs.…”