Sticky Platelet Syndrome: 35 Years of Growing Evidence

Kubisz, Peter; Holly, Pavol; Staško, Ján

doi:10.1055/s-0038-1676581

Cited by 20 publications

(3 citation statements)

References 69 publications

(89 reference statements)

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“…Our findings could also be related to the sticky platelet syndrome, a thrombophilic qualitative platelet disorder characterized by increased in vitro platelet adhesion and aggregation in response to very low concentrations of the weak platelet agonist ADP and/or epinephrine, and increased risk of arterial ischemic events [ 38 ]. This possibility deserves further investigation.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton’s Tyrosine Kinase

Duan¹,

Goldmann²,

Li³

et al. 2021

IJMS

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High platelet reactivity leading to spontaneous platelet aggregation (SPA) is a hallmark of cardiovascular diseases; however, the mechanism underlying SPA remains obscure. Platelet aggregation in stirred hirudin-anticoagulated blood was measured by multiple electrode aggregometry (MEA) for 10 min. SPA started after a delay of 2–3 min. In our cohort of healthy blood donors (n = 118), nine donors (8%) with high SPA (>250 AU*min) were detected. Pre-incubation of blood with two different antibodies against the platelet Fc-receptor (anti-FcγRIIA, CD32a) significantly reduced high SPA by 86%. High but not normal SPA was dose-dependently and significantly reduced by blocking Fc of human IgG with a specific antibody. SPA was completely abrogated by blood pre-incubation with the reversible Btk-inhibitor (BTKi) fenebrutinib (50 nM), and 3 h after intake of the irreversible BTKi ibrutinib (280 mg) by healthy volunteers. Increased SPA was associated with higher platelet GPVI reactivity. Anti-platelet factor 4 (PF4)/polyanion IgG complexes were excluded as activators of the platelet Fc-receptor. Our results indicate that high SPA in blood is due to platelet FcγRIIA stimulation by unidentified IgG complexes and mediated by Btk activation. The relevance of our findings for SPA as possible risk factor of cardiovascular diseases and pathogenic factor contributing to certain autoimmune diseases is discussed.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton’s Tyrosine Kinase

Duan¹,

Goldmann²,

Li³

et al. 2021

IJMS

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“…The most common SPS type is the SPS type II, followed by the SPS type I (approximately 30%). SPS type III is rarely found and diagnosed in only about 1% of SPS patients [35,36]. The different types improve clinically identical and there are no differences in treatment.…”

Section: Methodsmentioning

confidence: 99%

High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss

Yagmur¹,

Bast

Mühlfeld

et al. 2019

JCM

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Platelet hyperaggregability, known as sticky platelet syndrome (SPS), is a prothrombotic disorder that has been increasingly associated with pregnancy loss. In this retrospective study, we aimed to investigate the clinical and diagnostic relevance of SPS in 208 patients with infertility and unexplained pregnancy loss history. We studied 208 patients that had been referred to undergo a dose-dependent platelet aggregation response to adenosine diphosphate and epinephrine using light transmission aggregometry modified by Mammen during an 11-year period. Patients’ platelet aggregation response was compared with platelet function in 29 female healthy controls of fertile age with no previous history of pregnancy loss. We found a prevalence of SPS type II (33.2%) in 208 female patients with infertility and pregnancy loss. ∆-epinephrine-induced platelet aggregation in patients with SPS was significantly decreased (median 7% and range −21 to 43%) compared to patients without SPS (median 59%, range 7–88% and p < 0.0001) and healthy controls (median 57%, range 8–106% and p < 0.0001). The optimum SPS-diagnostic cutoff value for ∆-epinephrine aggregation was ≤32% (sensitivity 95.7%, specificity 95.2%). SPS patients with low-dose acetylsalicylic acid (ASA) therapy (n = 56) showed improved pregnancy outcome (32 pregnancies; live births n = 18 (56%)) compared to SPS patients without low-dose ASA (n = 13) (3 pregnancies; live births n = 1 (33%)). Our study demonstrates the clinical and diagnostic relevance of platelet hyperaggregation in women with infertility and pregnancy loss history. Further studies should investigate the potential of SPS as a novel decisional tool with both diagnostic and clinical implications in infertility and pregnancy loss.

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“…The first thrombotic event usually occurs before 40 years of age and without prominent acquired risk factors. Direct genetic background of this inherited thrombophilic disorder is not sufficiently known, but the genetic changes of platelet membrane receptors play a possible role in platelet activation and aggregation (1,2).…”

Section: Introductionmentioning

confidence: 99%

Platelet miRNA Expression in Patients with Sticky Platelet Syndrome

Belakova,

Zolkova,

Vadelova

et al. 2023

Acta Medica Martiniana

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Sticky platelet syndrome (SPS) is a disorder with familial occurrence and autosomal dominant trait characterized by platelet hyperaggregability in response to a low concentration of adenosine diphosphate (ADP) and/or epinephrine (EPI). The etiology of SPS may be associated with platelet microRNAs (miRNAs), which are considered as potential biomarkers of platelet function and antiplatelet therapy. We were monitoring the expression of platelet miRNAs in patients with laboratory diagnosed SPS and healthy controls. We have found a statistically significant increased expression of both miR-423-5p and miR-338-3p as well as a statistically significant decreased expression of miR-425-5p between the group of patients with diagnosed SPS type II and the group of healthy controls, which seems to be an interesting issue for a further research.

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Sticky Platelet Syndrome: 35 Years of Growing Evidence

Cited by 20 publications

References 69 publications

Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton’s Tyrosine Kinase

Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton’s Tyrosine Kinase

High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss

Platelet miRNA Expression in Patients with Sticky Platelet Syndrome

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