Stiffness measurements on spherical surfaces of prostate models, using a resonance sensor

Åstrand, Anders P.; Jalkanen, Ville; Andersson, Britt M.; Lindahl, Olof

doi:10.1007/978-3-642-29305-4_368

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…Three spherical silicone phantoms (Shore hardness 33) were cast using a mold with a diameter of 40 mm, as described in [ 30 , 31 ]. To simulate embedded stiffer nodules in soft tissue, inclusions of small spheres of silicone (Shore hardness 88) were made with diameters D = 2.5 mm, 4 mm, and 6 mm.…”

Section: Methodsmentioning

confidence: 99%

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Prostate Cancer Detection with a Tactile Resonance Sensor—Measurement Considerations and Clinical Setup

Åstrand

Andersson

Jalkanen

et al. 2017

Sensors

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Tumors in the human prostate are usually stiffer compared to surrounding non-malignant glandular tissue, and tactile resonance sensors measuring stiffness can be used to detect prostate cancer. To explore this further, we used a tactile resonance sensor system combined with a rotatable sample holder where whole surgically removed prostates could be attached to detect tumors on, and beneath, the surface ex vivo. Model studies on tissue phantoms made of silicone and porcine tissue were performed. Finally, two resected human prostate glands were studied. Embedded stiff silicone inclusions placed 4 mm under the surface could be detected in both the silicone and biological tissue models, with a sensor indentation of 0.6 mm. Areas with different amounts of prostate cancer (PCa) could be distinguished from normal tissue (p < 0.05), when the tumor was located in the anterior part, whereas small tumors located in the dorsal aspect were undetected. The study indicates that PCa may be detected in a whole resected prostate with an uneven surface and through its capsule. This is promising for the development of a clinically useful instrument to detect prostate cancer during surgery.

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Section: Methodsmentioning

confidence: 99%

“…For the other two, the inclusions with D = 4 mm and D = 2.5 mm, d were 2.2 mm and 1.6 mm. The procedure to position the stiffer nodules inside the mold has been described elsewhere [ 31 ]. The diameters of the nodules and depths were chosen to be close to the limit of detection for the 5 mm in diameter sensor tip used in this study [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Prostate Cancer Detection with a Tactile Resonance Sensor—Measurement Considerations and Clinical Setup

Åstrand

Andersson

Jalkanen

et al. 2017

Sensors

Self Cite

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“…Therefore, it is important to understand how the measured parameters of the resonance sensor are affected by different , I Z and v i . Therefore, we constructed a measurement system with adjustable positioning and movement features [12,13]. However, the maximum error of the system has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Contact angle and indentation velocity dependency for a resonance sensor—Evaluation on soft tissue silicone models

Åstrand¹,

Jalkanen²,

Andersson³

et al. 2013

Journal of Medical Engineering & Technology

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Human tissue stiffness can vary due to different tissue conditions such as cancer tumours. Earlier studies show that stiffness may be detected with a resonance sensor that measures frequency shift and contact force at application. Through the frequency shift and the contact force, a tissue stiffness parameter can be derived. This study evaluated how the probe application angle and indentation velocity affected the results and determined the maximum parameter errors. The evaluation was made on flat silicone discs with specified hardness. The frequency shift, the force and the stiffness parameter all varied with contact angle and indentation velocity. A contact angle of ≤10° was acceptable for reliable measurements. A low indentation velocity was recommended. The maximum errors for the system were <1.1% of the measured values. It was concluded that contact angle and indentation velocity have to be considered in the clinical setting. The angular dependency is especially important in clinical use for studying stiffness of human soft tissue, e.g. in prostate cancer diagnosis.

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Stiffness measurements on spherical surfaces of prostate models, using a resonance sensor

Cited by 2 publications

References 10 publications

Prostate Cancer Detection with a Tactile Resonance Sensor—Measurement Considerations and Clinical Setup

Prostate Cancer Detection with a Tactile Resonance Sensor—Measurement Considerations and Clinical Setup

Contact angle and indentation velocity dependency for a resonance sensor—Evaluation on soft tissue silicone models

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