1999
DOI: 10.1016/s0026-0495(99)90010-0
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Stiffness of the aortic wall in hypercholesterolemic children

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Cited by 37 publications
(26 citation statements)
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“…Iannuzzi et al demonstrated an influence of hypercholesterolemia on age-related modification in the elastic properties of the aorta. A remodelling of the aortic wall in HC children could explain the different age-dependent increase in aortic elastic modulus and stiffness [33]. Stiffness parameter b of the descending aorta assessed by TEE, which was measured in portions where the intima was morphologically normal or mildly thickened, was significantly higher in familial and non-familial hypercholesterolemic patients, thus clearifying that the stiffness of the aorta in hyperlipidemic patients has already been increased before exacerbation of aortic atherosis even begins [6].…”
Section: Comparison With Previous Studiesmentioning
confidence: 95%
See 1 more Smart Citation
“…Iannuzzi et al demonstrated an influence of hypercholesterolemia on age-related modification in the elastic properties of the aorta. A remodelling of the aortic wall in HC children could explain the different age-dependent increase in aortic elastic modulus and stiffness [33]. Stiffness parameter b of the descending aorta assessed by TEE, which was measured in portions where the intima was morphologically normal or mildly thickened, was significantly higher in familial and non-familial hypercholesterolemic patients, thus clearifying that the stiffness of the aorta in hyperlipidemic patients has already been increased before exacerbation of aortic atherosis even begins [6].…”
Section: Comparison With Previous Studiesmentioning
confidence: 95%
“…Several previous studies demonstrated impaired aortic distensibility evaluated by different techniques in HC patients [6,[32][33][34][35][36][37][38][39]. Severe dyslipidemia does not overtly influence aortic dimensions but leads to impairment of aortic elastic properties before the occurance of clinical manifestations of atherosclerotic disease [32].…”
Section: Comparison With Previous Studiesmentioning
confidence: 98%
“…These studies examined patients with familial hypercholesterolemia characterized by extremely high serum cholesterol levels. Earlier studies have also reported an absence of significant association between arterial stiffness and hyperlipidemia (38,39). One of these studies (38) examined hypercholesterolemic children at the age of 3 to 14 years.…”
Section: Hyperlipidemia and Pulse Pressurementioning
confidence: 99%
“…24-29 Decreased arterial elasticity can be detected in childhood in those with cardiovascular risk factors. 30, 31 Arterial stiffness can be assessed noninvasively using pulse wave velocity (PWV) or the β stiffness index (SI) of the carotid artery. 32 PWV measurement involves measuring the timing and magnitude of the reflected pressure wave that …”
Section: Vascular Stiffnessmentioning
confidence: 99%