Rationale-There is a paucity of information about the association of seizure severity and quality of life in people living with epilepsy (PLWE) in sub-Saharan Africa. We evaluated the relationship between seizure severity and health-related quality of life of patients with epilepsy being followed up in an outpatient neurology clinic in urban central Uganda Methods-Forty-eight PLWE who met the study inclusion criteria were enrolled. The study questionnaire was comprised of the Chalfont Seizure Severity Scale, and the Quality of Life Inventory in Epilepsy (QOLIE-31). Spearman's rank correlation coefficient was used to determine the association between seizure severity and quality of life score.
Results-The median age of the study participants was 25 years, with median age (IQR) of epilepsy onset of 12 (6−18) years. Over 57.4% of the study participants were unemployed. The mean (SD) of QOLIE-31 and Seizure Severity Score was 62.5 (14.5) and 62.4 (1. 6), respectively. There was no gender difference in the seizure severity scores (P = 0. 451). An inverse relationship existed between seizure severity and the total QOLIE-31 score (Spearman's rank correlation coefficient, r = −0.48, p = 0.001), and seizure worry (r = −0.31, p=0.030),