Stigmasterol activates Cdc42-Arp2 and Erk1/2-Creb pathways to enrich glutamatergic synapses in cultures of brain neurons

Haque, Md. Nazmul; Bhuiyan, Mohammad Maqueshudul Haque; Moon, Il Soo

doi:10.1016/j.nutres.2018.04.022

Cited by 24 publications

(10 citation statements)

References 25 publications

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“…Lipophilic profiles could show the presence of steroid derivatives, but those works are not included in this review because herein are just referred the isolated and fully characterized metabolites. Nevertheless, the presence of β-sitosterol derivatives seems to be important due to their recognised biological properties and potential use in treatment of various illnesses [42], but also stigmasterol seems to be a potential therapeutic agent for neurodegenerative diseases [43]. Therefore, S. stellata can be a source of these important secondary metabolites.…”

Section: Structural Pattern Of the Secondary Metabolites Isolated mentioning

confidence: 99%

Scabiosa Genus: A Rich Source of Bioactive Metabolites

et al. 2018

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The genus Scabiosa (family Caprifoliaceae) is considered large (618 scientific plant names of species) although only 62 have accepted Latin binominal names. The majority of the Scabiosa species are widely distributed in the Mediterranean region and some Scabiosa species are used in traditional medicine systems. For instance, Scabiosa columbaria L. is used traditionally against diphtheria while S. comosa Fisch. Ex Roem. and Schult. is used in Mongolian and Tibetan traditional medical settings to treat liver diseases. The richness of Scabiosa species in secondary metabolites such as iridoids, flavonoids and pentacyclic triterpenoids may contribute to its use in folk medicine. Details on the most recent and relevant pharmacological in vivo studies on the bioactive secondary metabolites isolated from Scabiosa species will be summarized and thoroughly discussed.

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Section: Structural Pattern Of the Secondary Metabolites Isolated mentioning

confidence: 99%

Scabiosa Genus: A Rich Source of Bioactive Metabolites

et al. 2018

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“…It also inhibited NMDA receptor-mediated excitotoxicity related to ischemic stroke [ 54 ]. Stigmasterol was reported to participate in axon and dendrite development, the modulation of synaptic transmission [ 55 ], reduction of amyloidogenic amyloid precursor protein (APP) processing, inhibition of acetylcholine esterase, and amelioration of memory impairment [ 56 ]. Ursolic acid protected the ischemic brain in mice by activating Nrf2 pathway, inhibiting the TLR4/NF- κ B pathway, and regulating metalloprotease/anti-metalloprotease imbalance [ 57 – 59 ].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology‐Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood‐Brain Barrier

Zhang

Wang

Cheng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Ischemic stroke is the most common type of cerebrovascular accident worldwide. It causes long-term disability and death. Qingkailing (QKL) injection is a traditional Chinese patent medicine which has been clinically applied in the treatment of ischemic stroke for nearly thirty years. In the present study, network pharmacology combined with experimentation was used to elucidate the mechanisms of QKL. ADME screening and target prediction identified 62 active compounds and 275 targets for QKL. Topological screening of the protein-protein interaction (PPI) network was used to build a core PPI network consisting of 408 nodes and 17,830 edges. KEGG enrichment indicated that the main signaling pathway implicated in ischemic stroke involved hypoxia-inducible factor-1 (HIF-1). Experimentation showed that QKL alleviated neurological deficits, brain infraction, blood-brain barrier (BBB) leakage, and tight junction degeneration in a mouse ischemic stroke model. Two-photon laser scanning microscopy was used to evaluate BBB permeability and cerebral microvessel structure in living mice. HIF-1α, matrix metalloproteinase-9 (MMP-9), and tight junction proteins such as occludin, zonula occludins-1 (ZO-1), claudin-5, and VE-Cadherin were measured by western blotting. QKL upregulated ZO-1 and downregulated HIF-1α and MMP-9. QKL has a multiapproach, multitarget, and synergistic effect against ischemic stroke.

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“…Wu et al found that Hederagenin could be used as novel autophagic enhancer to play a role in neuroprotection by improving motor deficits in Parkinson's disease mice model 34 . Stigmasterol could ameliorate memory impairment and promotes neuritogenesis and synaptogenesis 35,36 . Ginsenosides from ginseng showed the great therapeutic potential in AD 37,38 .…”

Section: Discussionmentioning

confidence: 99%

A Network Pharmacology-Based Study on Alzheimer disease prevention and treatment of Qiong Yu Gao

You

Chen

et al. 2020

Preprint

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Background and objective: As the pathological mechanisms of AD is complex, increasing evidence have demonstrated Chinese Medicine with multi-ingredients and multi-targets may be more suitable for the treatment of diseases with complex pathogenesis. Therefore, the study was to preliminarily decipher the bioactive compounds and potential mechanisms of Qiong Yu Gao (QYG) for AD prevention and treatment by an integrated network pharmacology approach. Methods: Putative ingredients of QYG and significant genes of AD were retrieved from public database after screening. Then QYG ingredients target proteins/genes were obtained by target fishing. Compound-target-disease network was constructed using Cytoscape to decipher the mechanism of QYG for AD. KEGG pathway and GO enrichment analysis were performed to investigate the molecular mechanisms and pathways related to QYG for AD treatments. Results: Finally, 70 compounds and 511 relative drug targets were collected. In which, 17 representative direct targets were found. Gene ontology enrichment analysis revealed that the adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway was the key biological processes and were regulated simultaneously by the 17 direct targets. KEGG pathway enrichment analysis found that three signaling pathways were closely related with AD treatment by QYG, including PI3K-Akt signaling pathway, regulation of actin cytoskeleton pathway and insulin resistance pathway. Conclusion: This study demonstrated that QYG exerted the effect of treating AD by regulating multi-targets with multi-components. Furthermore, the study demonstrated that a network pharmacology-based approach was useful for elucidation of the interrelationship between complex diseases and interventions of Chinese herbal medicines.

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Stigmasterol activates Cdc42-Arp2 and Erk1/2-Creb pathways to enrich glutamatergic synapses in cultures of brain neurons

Cited by 24 publications

References 25 publications

Scabiosa Genus: A Rich Source of Bioactive Metabolites

Scabiosa Genus: A Rich Source of Bioactive Metabolites

Network Pharmacology‐Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood‐Brain Barrier

A Network Pharmacology-Based Study on Alzheimer disease prevention and treatment of Qiong Yu Gao

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