Stilbenes and Its Derivatives and Glycosides

Hădărugă, Nicoleta-Gabriela; Hădărugă, Daniel-Ioan

doi:10.1007/978-3-030-81404-5_14-1

Cited by 1 publication

(1 citation statement)

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“…The geometrical compatibility and the favorable interaction energy of guest compounds (Rv and CP) with the host molecule, γ-CD, were theoretically evaluated by molecular modeling and docking experiments [32][33][34][35]. First, the molecules were built up using the Add Hydrogen & Model Build module in HyperChem 7.52 (HyperCube, Inc., Gainesville, FL, USA).…”

Section: Molecular Modeling and γ-Cd Docking Of Resveratrol And Cispl...mentioning

confidence: 99%

Beneficial Effects of Resveratrol and γ-Cyclodextrin on the Hematological and Biochemical Parameters of Healthy Wistar Rats Treated with Cisplatin: A PCA Approach

Hădărugă,

Gârban,

Baltă

et al. 2023

Biomedicines

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It is well known that platinum-based antineoplastic agents, including cisplatin (CP), have side effects that limit their use. Nefrotoxicity, neurotoxicity, and hemolytic anemia are the most common side effects. There are few studies on the reduction in these effects that involves nanoencapsulation; however, almost none involve cyclodextrins (CDs). Changes in the hematological and biochemical parameters of healthy Wistar rats treated with solutions of γ-cyclodextrin/resveratrol/cisplatin (γ-CD/Rv/CP) ternary complexes are investigated for the first time. They are intraperitoneally injected with γ-CD/Rv/CP solutions containing 5 mg CP/kg.b.w. Single shots were administered to six groups of Wistar rats (six individuals for every group) using γ-CD/Rv/CP, γ-CD/CP, γ-CD/Rv complexes, as well as positive- and negative-control groups, respectively. Thirty-two hematological and biochemical parameters were evaluated from blood samples and used as input variables for the principal component analysis (PCA) discrimination of the groups. The best protection was obtained for the γ-CD/Rv/CP ternary complex, which determined closer biochemical values to the control group. These values significantly differ from those of the γ-CD/CP treated group, especially for the IP, UA, and T-Pro kidney-related biochemical parameters. This finding proves the beneficial influence of Rv during CP administration through CD-based carriers.

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Section: Molecular Modeling and γ-Cd Docking Of Resveratrol And Cispl...mentioning

confidence: 99%