Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model

Gao, Yidan; Wu, Yun; Tie, Fangfang; Wang, Honglun

doi:10.1016/j.heliyon.2024.e32007

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e32007

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Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model

Yidan Gao,

Yun Wu,

Fangfang Tie

et al.

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Antidiabetic potential of fenugreek (Trigonella foenum‐graecum): A magic herb for diabetes mellitus

Sarker,

Ray,

Dutta

et al. 2024

Food Science & Nutrition

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Fenugreek (Trigonella foenum‐graecum) is a widely grown dietary herb in Asia, and its seeds are traditionally used for several diseases, including diabetes. The seeds and leaves possess a variety of compounds that play an important role in regulating their hypoglycemic effect. However, so far, no extensive systematic review exists on its antidiabetic effect, highlighting the molecular mechanisms and isolated compounds. The purpose of this review is to summarize the preclinical and clinical antidiabetic properties of fenugreek and its isolated compounds by focusing on underlying mechanisms. PubMed, Google Scholar, Science Direct, and Scopus databases were searched to retrieve articles until June, 2024. Preclinical studies demonstrated that the antidiabetic effect of fenugreek was mostly associated with enhanced glucose transporter type‐4 (GLUT4) translocation and hexokinase activity, decreased glucose‐6‐phosphatase and fructose‐1,6‐bisphosphatase activities, inhibited α‐amylase and maltase activities, protected β cells, and increased insulin release. Furthermore, few studies have reported its role as a glucagon‐like peptide‐1 (GLP‐1) modulator, 5′‐AMP‐activated kinase (AMPK) activator, and dipeptidyl peptidase‐IV (DPP‐IV) inhibitor. Further clinical trials showed that fenugreek seeds improved blood glucose levels, insulin resistance, insulin sensitivity, and lipid profiles. This study highlights significant evidence of the antidiabetic effect of fenugreek and its isolated compounds; therefore, it could be a potential therapy for diabetes.

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Antidiabetic potential of fenugreek (Trigonella foenum‐graecum): A magic herb for diabetes mellitus

Sarker,

Ray,

Dutta

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Effects of arginine supplementation in high-carbohydrate diets on the growth, hematological parameters, and hepatic and skeletal muscle glucose metabolism of juvenile mirror carp (Cyprinus carpio) based on PI3K/Akt signaling pathway

Li,

Fan,

et al. 2024

Aquaculture Reports

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Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model

Cited by 2 publications

References 56 publications

Antidiabetic potential of fenugreek (Trigonella foenum‐graecum): A magic herb for diabetes mellitus

Antidiabetic potential of fenugreek (Trigonella foenum‐graecum): A magic herb for diabetes mellitus

Effects of arginine supplementation in high-carbohydrate diets on the growth, hematological parameters, and hepatic and skeletal muscle glucose metabolism of juvenile mirror carp (Cyprinus carpio) based on PI3K/Akt signaling pathway

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