Still's Disease, Severe Thrombocytopenia, and Acute Hepatitis Associated with Acute Parvovirus B19 Infection

Longo, Giuseppe; Luppi, Mario; Bertesi, Marcello; Ferrara, Leonardo; Torelli, Giuseppe; Emilia, Giovanni

doi:10.1086/517644

Cited by 36 publications

(16 citation statements)

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“…The results obtained for case 3 corroborate other data providing evidence that parvovirus B19 may be a cause of hepatic dysfunction by mechanisms that are not yet elucidated (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Some authors suggest a direct effect of parvovirus B19 infection after interaction with its cellular receptors, the erythrocyte P antigens, which are present on erythroid and liver cells (29).…”

Section: Discussionsupporting

confidence: 85%

“…Liver dysfunctions associated with parvovirus B19 have been described by several authors, especially involving acute hepatitis cases (3)(4)(5)(6)(7)(8)(9)(10)(11)(12), and the transmission of parvovirus B19 to patients with liver diseases has possibly led to exacerbations of disease in patients with cirrhosis (13) and liver transplant (14).…”

Section: Introductionmentioning

confidence: 99%

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Detection of human parvovirus B19 in a patient with hepatitis

Pinho

Alves

Vieira

et al. 2001

Braz J Med Biol Res

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Parvovirus B19 has been associated by some investigators with cases of severe hepatitis. The aim of the present study was to determine the presence of active parvovirus B19 infection among 129 Brazilian patients with non-A-E hepatitis. The patients were assayed for antibodies against parvovirus B19, IgM class, by ELISA. In IgM-positive cases, parvovirus B19 DNA was assayed by PCR in serum and liver tissue and parvovirus VP1 antigen in liver tissue was assayed by immunohistochemistry. Antibodies against parvovirus B19, IgM class, were detected in 3 (2.3%) of 129 patients with non-A-E hepatitis. Previous surgery and blood transfusions were reported by these 3 patients. One patient was a 56-year-old female with severe hepatitis, with antimitochondrial antibody seropositivity and submassive necrosis at liver biopsy, who responded to corticosteroid therapy. Strong evidence for active parvovirus B19 infection was found in this patient, with parvovirus B19 DNA being detected by PCR in liver tissue. Furthermore, parvovirus VP1 antigen was also detected in liver tissue by immunohistochemistry. The other two IgM-positive patients were chronic hepatitis cases, but active infection was not proven, since neither viral DNA nor antigen were detected in their liver tissues. This and other reports suggest a possible relation between parvovirus B19 infection and some cases of hepatitis.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Detection of human parvovirus B19 in a patient with hepatitis

Pinho

Alves

Vieira

et al. 2001

Braz J Med Biol Res

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“…A temporary but moderated thrombocytopenia was reported in another case for which no platelet count was available (2). Thrombocytopenia has been previously reported in children and adults in primary infections with various other viruses, including severe forms that involved, for instance, hepatitis A virus (12), Epstein-Barr virus (9), or parvovirus B19 (6). The mechanisms of severe thrombocytopenia in the setting of acute viral infection is believed to be immune mediated, and platelet-associated antibodies have been frequently reported (9,11).…”

Section: Case Reportmentioning

confidence: 99%

Severe Thrombocytopenia Associated with Acute Hepatitis E Virus Infection

et al. 2008

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We describe here what is, to the best of our knowledge, the third reported case of severe thrombocytopenia associated with acute hepatitis E virus infection. The patient was a 72-year-old French woman. It seems likely that the cause of the thrombocytopenia was acute hepatitis E virus infection, possibly occurring via an immune mechanism. No complications were noted, in contrast to the two previous reports.

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“…Several reports have suggested a triggering infection in ASD [3][4][5][6][7][8][9][10]. We describe a patient with ASD associated with acute Mycoplasma pneumoniae infection.…”

Section: Adult Still's Disease (Asd) Is a Systemic Inflammatory Disormentioning

confidence: 94%

“…Laboratory studies were notable for the following values: erythrocyte sedimentation rate, 116 mm/h; hemoglobin, 10 A chest radiograph showed an infiltrate of the left lower lobe. Findings on radiographs of shoulders, elbows, wrists, knees, and ankles were normal.…”

Section: Adult Still's Disease (Asd) Is a Systemic Inflammatory Disormentioning

confidence: 99%

Adult Still's Disease Associated with Mycoplasma pneumoniae Infection

Pérez

Artola

2001

Clinical Infectious Diseases

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Adult Still's disease (ASD) is a systemic inflammatory disorder of unknown origin. Several reports have suggested a triggering infection in ASD. We describe a case of ASD associated with acute Mycoplasma pneumoniae infection. The close temporal relationship between ASD and acute infection strongly suggests that M. pneumoniae triggered ASD. We suggest that M. pneumoniae should be added to the list of infectious agents that may play a role in its etiology.

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Still's Disease, Severe Thrombocytopenia, and Acute Hepatitis Associated with Acute Parvovirus B19 Infection

Cited by 36 publications

References 0 publications

Detection of human parvovirus B19 in a patient with hepatitis

Detection of human parvovirus B19 in a patient with hepatitis

Severe Thrombocytopenia Associated with Acute Hepatitis E Virus Infection

Adult Still's Disease Associated with Mycoplasma pneumoniae Infection

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