Still seeking balance in opioid management for acute sickle cell disease pain

Fasipe, Titilope; Hulbert, Monica L.

doi:10.1002/pbc.29741

Cited by 1 publication

(2 citation statements)

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“…[14] [17] Since opioids form the mainstay of management of severe vasoocclusive episodes, there are always concerns about the effects of prolonged use of opioids including tolerance-in which increasingly higher doses are required to produce the same pharmacologic effect, physical dependence-in which continual usage of the drug is required for biologic functioning and opioid induced hyperanalgesia (OIH) in which the experience of pain is amplified because of the sensitization of the nociceptive pathways. [20] The use of short acting opioids such as pentazocine mainly in Nigeria contributes to these concerns as it has a short half-life and can predispose the patient seeking more doses to relieve their pain.…”

Section: ]mentioning

confidence: 99%

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Management of Opioid Use Disorder in Sickle Cell Anaemia amidst Growing Menace in the General Population

Aboluwarin,

Ojuawo,

Akanbi

et al. 2023

OJPed

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Nigeria has a very high number of sickle cell disease (SCD) population with addition of 150,000 babies born annually with the disease. Early infant diagnosis and good care make many of these babies survive to adulthood. Severe pain requiring moderately strong or very strong analgesics is a common presentation of patients with Sickle Cell Anaemia. Paediatricians find ready usefulness of Opioids which are very useful for the painful episodes among these patients. Therefore, the chances of abuse and addiction to these medications become very high and constitute additional burden on the deficient manpower in the health sector. Opioid Use Disorder among Sickle Cell Disease patients has subtle presentation, so a high index of suspicion is required to make both the diagnosis and referral to treatment centres. In this review, the epidemiology, pain pathophysiology, behavioural and pharmacologic therapy have been re-examined.

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Section: ]mentioning

confidence: 99%

“…Apart from being useful in managing opioid use disorder, CBT can also be used as a non-pharmacologic strategy for coping with pain in SCD. [20] [24]…”

Section: Cognitive Behavioural Therapymentioning

confidence: 99%