Stillbirth Due to Haemolytic Disease of the Newborn

Walker, William O.; Murray, Sheilagh; Russell, J. K.

doi:10.1111/j.1471-0528.1957.tb06287.x

Cited by 35 publications

(7 citation statements)

References 15 publications

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“…On the whole, anti‐D prophylaxis is an example of a significant triumph of modern preventive medicine. In England and Wales, registered deaths due to RhHDN fell from 1 in 2180 births in 1953 to 1 in 5400 in 1977 and to 1 in 62,500 in 1990 19–21 . The frequency of Rh immunisation has also decreased considerably since the introduction of RhD prophylaxis.…”

Section: Antenatal Prophylaxismentioning

confidence: 99%

The prevention of Rh haemolytic disease of the fetus and newborn — general background

Contreras

1998

BJOG

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Section: Antenatal Prophylaxismentioning

confidence: 99%

The prevention of Rh haemolytic disease of the fetus and newborn — general background

Contreras

1998

BJOG

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“…6 Even if affected, haemolytic disease in the first affected infant was less severe when compared to subsequently affected siblings. 7 In our study, a single case of Rh-D HDFN occurred in a primigravida who was previously sensitised by an out of group platelet transfusion for dengue haemorrhagic fever two years back.…”

Section: Amongmentioning

confidence: 61%

“…13 Walker et al noticed that the risk of stillbirth in a woman who previously delivered mildly affected infant was 2%, whereas in a woman who delivered one previous stillbirth was as high as 70%. 7 In this analysis, eleven mothers of infants with Rh-D HDFN had undergone postpartum RhIG prophylaxis during previous deliveries. Since intrauterine transfusion was not practiced in study setting, there was no single foetus that had undergone the same.…”

Section: Amongmentioning

confidence: 99%

CLINICAL CHARACTERISTICS AND MANAGEMENT OF Rh-D HAEMOLYTIC DISEASE OF NEWBORN

Vilambil¹,

Dharmadas²,

Usha³

et al. 2017

jemds

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BACKGROUNDIn Rh-D haemolytic disease of foetus and newborn (HDFN), newborns can be severely affected, thereby associated with extensive morbidity and mortality. Aim-The aim of this study is to describe the clinical profile of Rh-D HDFN. Settings and Design-This was a descriptive study conducted in newborn, who had Rh-D HDFN. Setting was Depts. of Transfusion Medicine and Paediatrics in Govt. Medical College, Trivandrum. MATERIALS AND METHODSEnrolment of newborn was done according to inclusion criteria. Maternal and neonatal details were noted and risk of jaundice, severity of disease and intensity of treatment was assessed. Statistical Analysis-All statistical data were analysed using SPSS software version 16. RESULTS 29 (65.9%) belonged to male gender and 15 (34.1%) to female gender. The mean bilirubin levels in neonates on Day 1, 2, 3, 4 and 5 were 4.15, 6.66, 9.44, 11.1 and 11.14 mg% respectively; 20 (45.5%) belonged to low risk, 13 (29.5%) to low intermediate risk, 7 (15.9%) to high intermediate risk and 4 (9.1%) to high risk categories; 4 (9.1%) belonged to no anaemia category, 17 (38.6%) belonged to mild anaemia category, 19 (43.2%) to moderate category and 4 (9.1%) to severe category; 35 (79.5%) of infants showed signs of haemolysis; 33 (75%), 7 (15.9%), 3 (6.8%) and 1 (2.3%) infants had mild, moderate, severe and very severe disease respectively; 20 (45.5%) infants required no treatment; 13 (29.5%) infants were treated only with phototherapy. IVIG was given along with phototherapy in 7 (15.9%) infants; 4 (9.1%) infants were treated with exchange transfusion along with IVIG and phototherapy. Neonates were transfused with 9 (20.5%) packed red blood cells, 3 (6.8%) platelets and 2 (4.5%) fresh frozen plasma. Results of intensity of treatment was 20 (45.5%) belonged to grade 0, 13 (29.5%) to grade 1 category; 7 (15.9%) fell into grade 2, 3 (6.8%) into grade 3 and 1 (2.3%) into grade 4 category of treatment. CONCLUSIONMale infants had higher risk of developing Rh-D HDFN. Majority of infants had mild hyperbilirubinaemia and anaemia only. Disease was mild among 3/4 th of infants and almost half of the infants required no treatment.

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“…The national mortality for cases of HDN at the time was 14%. Walker and Murray concluded that it could be brought down to 2% with optimal treatment (Walker et al 1957). George Knox, a medically qualified statistician working with Walker in Newcastle, did much of the work and thinking that allowed Cyril (later Sir Cyril) Clarke (FRS 1970) in Liverpool to develop anti-D prophylaxis, which resulted in the dramatic fall in incidence and deaths from HDN.…”

Section: Haemolytic Disease Of the Newbornmentioning

confidence: 99%

Patrick Mollison CBE. 17 March 1914—26 November 2011

CraftAlan

2020

Biogr. Mems Fell. R. Soc.

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Patrick Mollison was a pioneer in blood transfusion, playing a major role in changing it from a risky procedure to one which is now extremely safe. The urgent need for blood during World War II provided a stimulus for the development of this important lifesaving measure. His first major contribution was to devise a mechanism whereby blood could be stored for more than just short periods. Mixing donated blood with acid–citrate–dextrose (ACD) became a standard procedure for almost 30 years and was used worldwide. He later took a special interest in haemolytic disease of the newborn (HDN), which was largely due to Rhesus incompatibility between mother and baby. He was also involved with work which eventually led to HDN becoming preventable with the use of anti-D treatment of mothers. He wrote the first standard textbook on blood transfusion; almost 70 years later it is in its eleventh edition and still bears his name in the title. He spent his working life in blood transfusion and the study of the scientific aspects of this subject, developing a university department at Hammersmith Hospital and publishing almost 200 scientific papers as well as the textbook. He was very much a clinical scientist rather than a front-line clinician, although he was physician to Her Majesty Queen Elizabeth and was present at the birth of all four of her children.

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Stillbirth Due to Haemolytic Disease of the Newborn

Cited by 35 publications

References 15 publications

The prevention of Rh haemolytic disease of the fetus and newborn — general background

The prevention of Rh haemolytic disease of the fetus and newborn — general background

CLINICAL CHARACTERISTICS AND MANAGEMENT OF Rh-D HAEMOLYTIC DISEASE OF NEWBORN

Patrick Mollison CBE. 17 March 1914—26 November 2011

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