Stimbiotics Supplementation Promotes Growth Performance by Improving Plasma Immunoglobulin and IGF-1 Levels and Regulating Gut Microbiota Composition in Weaned Piglets

Chen, Wen Ning; Yin, Chenggang; Li, Jing; Sun, Wenjuan; Yan-pin, LI; Wang, Chengwei; Pi, Yu; Cordero, Gustavo; Li, Xilong; Jiang, Xianren

doi:10.3390/biology12030441

Cited by 7 publications

(7 citation statements)

References 50 publications

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“…Long-chain (n-3) fatty acids [65] and symbiotics [66] are additives that have profiles that can replace APCs [67] and are able to preserve the intestinal health of piglets via the maintenance of alpha and beta diversity without causing intestinal dysbiosis, an effect observed in all groups of this study for both diversities (Figures 1 and 2).…”

Section: Gut Microbiotamentioning

confidence: 78%

Enhancing Weaned Piglet Health and Performance: The Role of Autolyzed Yeast (Saccharomyces cerevisiae) and β-Glucans as a Blood Plasma Alternative in Diets

Barducci,

Santos,

Pacheco

et al. 2024

Animals

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The objective of this study was to evaluate the inclusion of the autolyzed yeast (AY) Saccharomyces cerevisiae with or without an immunomodulator (1,3/1,6 β-glucans) as a total/partial substitute for blood plasma (BP) in the diet of post-weaning piglets; zootechnical performance, intestinal health and microbiota, immune responses and energy metabolism were assessed. A total of 240 castrated male and female piglets, with a mean age of 22 days and mean initial weight of 5.24 ± 0.82 kg, were randomly divided into blocks of four treatments with 12 replicates. The dietary inclusions were blood plasma (BP), autolyzed yeast (AY), autolyzed yeast + immunomodulator (AYI) and 50% BP and 50% AY (BPAY). In pre-initial phase II (29–35 days), piglets fed AY showed better feed conversion (FCR = 1.358) than the piglets in the BP (1.484), AYI (1.379) and BPAY (1.442) groups, i.e., 8.49% (0.126), 1.52% (0.021) and 4.50% (0.084), respectively (p = 0.0293). In the total period (21–42 days), better FCR was observed in the AYI (1.458) group, i.e., 4.64% (0.071), 1.15% (0.017) and 4.58% (0.070), than in the BP (1.529), AY (1.475) and BPAY (1.528) groups, respectively (p = 0.0150). In piglets fed AY (n = 3) and BPAY (n = 2), there was a reduction in the number of medications, i.e., 82.35% (−14n) and 88.23% (−15n), respectively (p = 0.0001), compared with that in the BP group (n = 17). In the AY group (73.83 mg/dL), AYI group (69.92 mg/dL), and BPAY group (69.58 mg/dL), piglets exhibited increases in triglyceride levels of 79.32%, 69.83%, and 69.00%, respectively, in comparison to those in the BP group, which had triglyceride levels of 41.17 mg/dL (p = 0.0400). The beta-hydroxybutyrate concentration in the AY group (79.96 ng/μL) was lower by 31.95%, 22.64%, and 5.89% compared to the BP group (117.50 ng/μL), AYI group (103.36 ng/μL), and BPAY group (84.67 ng/μL), respectively (p = 0.0072). In the AYI group, there was modulation of the microbiota, with an increase in the relative abundance of bacteria of the genera Lactobacillus, Collinsella and Bulleidia. AY, associated or not associated with an immunomodulator, is a potential substitute for BP in diets for piglets in the nursery phase, with positive effects on immune, metabolic, and intestinal microbial performance.

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Section: Gut Microbiotamentioning

confidence: 78%

Enhancing Weaned Piglet Health and Performance: The Role of Autolyzed Yeast (Saccharomyces cerevisiae) and β-Glucans as a Blood Plasma Alternative in Diets

Barducci,

Santos,

Pacheco

et al. 2024

Animals

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“…The above results match our results. At the same time, the level of immunoglobulin can also affect production performance [ 40 ], which is one of the reasons for the improvement in production performance after IMCS training.…”

Section: Discussionmentioning

confidence: 99%

Intermittent and Mild Cold Stimulation Maintains Immune Function Stability through Increasing the Levels of Intestinal Barrier Genes of Broilers

Xing

Zhang

et al. 2023

Animals

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In order to improve the adaptability of broilers to low-temperature environments and their ability to resist acute cold stress (ACS), 240 one-day-old broilers were selected and randomly divided into three groups. The control treatment (CC) group was raised at the conventional feeding temperature from 1–43 days (d), the cold stimulation treatment (CS) group was kept at 3 °C below the temperature of CC at 1 d intervals for 3 and 6 h from 15 to 35 d, namely, CS3 and CS6, respectively. Then, all broilers were kept at 20 °C from 36 to 43 d. ACS was then carried out at 44 d, and the ambient temperature was dropped to 10 °C for 6 h. The study investigated the production performance, as well as levels of intestinal barrier genes (including Claudin-1, E-cadherin, Occludin, ZO-1, ZO-2 and Mucin2), secretory IgA in duodenum and jejunum, and immunoglobulins (IgA and IgG) in serum. The results showed that IMCS could increase the daily weight gain and decrease the feed conversion ratio. During IMCS, the expression levels of intestinal barrier genes were up-regulated and the content of secretory IgA was increased. When IMCS ceased for one week, the level of immunoglobulins in serum stabilized, and the expression levels of Occludin, ZO-2 and Mucin2 still maintained high levels. After ACS, broilers that received IMCS training maintained high levels of intestinal barrier genes and secretory IgA.

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“…IgA is the main component of mucosal defense system and is the rst line of defense against pathogenic invasion. Among the plasma immunoglobulins, IgG occurs at the highest concentrations, and is an important component in the resistance to infection [17]. IL-2 is an indicator of anti-tumor immune function and not only stimulates the growth, proliferation and differentiation of T cells, but also functions as an important immune enhancer [18].…”

Section: Effect Of Supplemental Feeding Lactobacillus Rhamnosus and C...mentioning

confidence: 99%

Effect of supplemental feeding of Lactobacillus rhamnosus and compound probiotics on growth performance, immunity, fecal fermentation parameters and microbiota structure of suckling foals

WANG,

ZHANG,

et al. 2024

Preprint

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(1) In this study, we investigated the effects of dietary supplementation with Lactobacillus rhamnosus and compound probiotics on the growth performance and microbiota structure of suckling Ili horse foals (aged 1 month; average weight 69.83 ± 13.76 kg). (2) At d 0, d 30, d 60 and d 90 of the regular feeding period, the weights of the foals were recorded, blood samples were obtained from the jugular vein and feces were collected by rectal extraction for the determination of microbial diversity and fermentation parameters. (3) The results showed that dietary supplementation with Lactobacillus rhamnosus and compound probiotics in 1-month-old suckling foals affected the production of volatile fatty acids in the intestine by changing the composition and abundance of intestinal microorganisms, promoting the digestion and absorption of nutrients, enhancing the level of nutrient metabolism and immunity to promote growth performance. (4) In conclusion, dietary supplementation with Lactobacillus rhamnosus and compound probiotics has a time-dependent positive effect on the growth performance of suckling foals.

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Stimbiotics Supplementation Promotes Growth Performance by Improving Plasma Immunoglobulin and IGF-1 Levels and Regulating Gut Microbiota Composition in Weaned Piglets

Cited by 7 publications

References 50 publications

Enhancing Weaned Piglet Health and Performance: The Role of Autolyzed Yeast (Saccharomyces cerevisiae) and β-Glucans as a Blood Plasma Alternative in Diets

Enhancing Weaned Piglet Health and Performance: The Role of Autolyzed Yeast (Saccharomyces cerevisiae) and β-Glucans as a Blood Plasma Alternative in Diets

Intermittent and Mild Cold Stimulation Maintains Immune Function Stability through Increasing the Levels of Intestinal Barrier Genes of Broilers

Effect of supplemental feeding of Lactobacillus rhamnosus and compound probiotics on growth performance, immunity, fecal fermentation parameters and microbiota structure of suckling foals

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