Stimulated embryo production as a parameter of estrogenic exposure via sediments in the freshwater mudsnail Potamopyrgus antipodarum

Duft, Martina; Schulte‐Oehlmann, Ulrike; Weltje, Lennart; Tillmann, Michaela; Oehlmann, Jörg

doi:10.1016/s0166-445x(03)00102-4

Cited by 137 publications

(71 citation statements)

References 32 publications

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“…Furthermore, Andersen et al (1999) reported an increased egg production in the copepod Acartia tonsa induced by BPA. Duft et al (2003) found an increased embryo production in BPA-treated specimens of the mudsnail Potamopyrgus antipodarum. Corresponding effects (especially a higher maturity index) were observed in a very recent field study with gammarids sampled at a site downstream of a sewage treatment plant Schirling et al, 2005).…”

Section: Discussionmentioning

confidence: 87%

“…It is a key building block of polycarbonates and can be found in many products like epoxy resin, dental sealants and composites, as well as in coatings of metal food and beverage cans. So far, only a few studies have reported effects of BPA on invertebrates (Watts et al, 2001a;Jobling et al, 2002;Pascoe et al, 2002;Duft et al, 2003;Segner et al, 2003) and the mode of action in these organisms remains still unknown.…”

Section: Introductionmentioning

confidence: 99%

“…G. fossarum is a keystone species and a representative for other invertebrates of the lotic communities because of its function as shredder and its importance for the food chain. As previous studies indicated, BPA is able to affect reproductive and developmental processes in invertebrates like the number of eggs produced by Potamopyrgus antipodarum (Duft et al, 2003) or the emergence time and percentage of adults in Chironomus riparius (Watts et al, 2001b). As well, our endpoints for the investigations were selected according to their association with the reproductive system, and included biochemical as well as histological parameters.…”

Section: Introductionmentioning

confidence: 99%

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Bisphenol A in Artificial Indoor Streams: II. Stress Response and Gonad Histology in Gammarus fossarum (Amphipoda)

et al. 2005

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The effects of the world wide-distributed chemical bisphenol A (BPA) on the endocrine system of vertebrates have been demonstrated in several studies. Here, we report on the impact of BPA (0, 5, 50 and 500 microg/l nominally, deduced effective concentrations 0, 0.24, 2.4, and 24.1 microg/l, respectively, all at 15 degrees C) on the 70 kD stress protein family (hsp70), the 90 kD stress protein family (hsp90), and gonad histology of the crustacean Gammarus fossarum exposed in artificial indoor streams. The animals were exposed for a maximum of 103 days and samples were taken at the beginning and at days 34, 69 and 103 of the experiment. Exposure to BPA resulted in accelerated maturation of oocytes in females and in a decline in the number and size of early vitellogenic oocytes. The level of hsp90, which plays a pivotal role in vertebrate sex steroid signal transduction, was significantly reduced by BPA. In all five streams, measured parameters did not indicate any captivity stress for a period of 69 days. Beyond this time, the mortality rate and proteotoxic effects, the latter measured by hsp70 expression, were found to be elevated.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bisphenol A in Artificial Indoor Streams: II. Stress Response and Gonad Histology in Gammarus fossarum (Amphipoda)

et al. 2005

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“…Many studies confirmed the inverted U response that classical endocrinology acknowledges (Duft et al 2003;Gupta 2000;Jobling et al 2003;Markey 2001a;Takai 2000;Talsness et al 2000). These new studies demonstrated that exposure to a biologically active chemical within the range in which free hormones operate can have an entirely different suite of effects that change during progressive stages of development than when the same chemical is administered in high doses after an individual has fully developed.…”

Section: Paradigm-breaking Approachesmentioning

confidence: 71%

Commentary: Setting Aside Tradition When Dealing with Endocrine Disruptors

Colborn

2004

ILAR Journal

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In 1996, the US Congress directed the Environmental Protection Agency to produce screens and assays to detect estrogenic and other endocrine-disrupting chemicals in food and water. To date, there are none. Years have been wasted in attempts to utilize traditional toxicological approaches to solve the problem, when in retrospect, it is now apparent that the delay in part stems from the reluctance to attack the problem with entirely new approaches. To develop new testing protocols, it is necessary to set aside much of the dogma of toxicology and to begin again with open minds. A few pertinent examples are provided concerning what has been overlooked and what needs to be done. In particular, it is necessary to give close attention to the selection of animal strain and diet, factors that were only loosely controlled historically when one takes into consideration what has been learned in the last decade. Vast numbers of animals have been sacrificed, and more will be sacrificed, in futile attempts to validate assays and to develop safety standards unless knowledge gained over the past decade concerning the sensitivity and complexity of the endocrine system is taken into consideration.

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“…Potential for effects from AP-contaminated sediments has been demonstrated for crustacea (Zulkosky et al, 2002 -see above) and molluscs: Duft et al (2003) showed that embryo production in the gastropod Potamopyrgus antipodium was stimulated in response to long-term exposure to sediments spiked with environmentally realistic concentrations of EDs (OP, NP and BPA). The lowest observed effect concentration (LOEC) was 1 µg kg -1 for all test compounds.…”

Section: Current Environmental Protection Measures and Gaps In Risk Amentioning

confidence: 99%

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

et al. 2005

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This review provides insights into the distribution and impact of oestrogens and xenooestrogens in the aquatic environment and highlights some significant knowledge gaps in our understanding of endocrine disrupting chemicals. Key areas of uncertainty in the assessment of risk include the role of estuarine sediments in mediating the fate and bioavailability of environmental (xeno)oestrogens (notably their transfer to benthic organisms and estuarine food chains), together with evidence for endocrine disruption in invertebrate populations.Emphasis is placed on using published information to interpret the behaviour and effects of a small number of 'model compounds' thought to contribute to oestrogenic effects in nature; namely, the natural steroid 17β-estradiol (E2) and the synthetic hormone 17α-ethinylestradiol (EE2), together with the alkylphenols octyl-and nonylphenol (OP, NP) as oestrogen mimics. Individual sections of the review are devoted to sources and concentrations of (xeno)oestrogens in waterways, sediment partitioning and persistence, bioaccumulation rates and routes, assays and biomarkers of oestrogenicity, and, finally, a synopsis of reproductive and ecological effects in aquatic species.

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Stimulated embryo production as a parameter of estrogenic exposure via sediments in the freshwater mudsnail Potamopyrgus antipodarum

Cited by 137 publications

References 32 publications

Bisphenol A in Artificial Indoor Streams: II. Stress Response and Gonad Histology in Gammarus fossarum (Amphipoda)

Bisphenol A in Artificial Indoor Streams: II. Stress Response and Gonad Histology in Gammarus fossarum (Amphipoda)

Commentary: Setting Aside Tradition When Dealing with Endocrine Disruptors

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

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