Stimulated TNF-α release in macrophage and enhanced migration of dermal fibroblast by β-glucan

Son, Hyun Joo; Han, Dong‐Wook; Baek, Hyun Sook; Lim, Hye Ryeon; Lee, Mi Hee; Woo, Yeon I.; Park, Jong Chul

doi:10.1016/j.cap.2006.11.010

Cited by 6 publications

(1 citation statement)

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“…Chronic wounds are characterized by a prolonged inflammatory phase where macrophages in granulation tissue, after stimulation with β-glucans, act as a source of growth factors and inflammatory cytokines (IL-6, IL-1β and TNFα), this pro-inflammatory event being mediated by the Dectin-1 receptor [ 18 ]. In another experiment, it was verified that macrophages can also stimulate other cells such as keratinocytes and fibroblasts that reepithelialize the wound and create granulation tissue [ 19 , 20 ].…”

Section: Wound Healing Activity Of β-Glucans: In Vitro Experimentsmentioning

confidence: 99%

β-Glucans: Multi-Functional Modulator of Wound Healing

Majtán

Jeseňák

2018

Molecules

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β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases.

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Section: Wound Healing Activity Of β-Glucans: In Vitro Experimentsmentioning

confidence: 99%