Stimulating Effect of Gastrin on Cell Proliferation Kinetics in Canine Fundic Mucosa

Willems, Glenda; Vansteenkiste, Y.; Limbosch, Jean-Michel

doi:10.1016/s0016-5085(72)80042-8

Cited by 147 publications

(26 citation statements)

References 17 publications

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“…This is in agreement with a previous study in which gastrin or histamine in equivalent doses with regard to acid secretion was administered to dogs for 4 h (24). Gastrin increased the labelling index, whereas histamine had no effect (24). The present study used a longer period of stimulation (2 days).…”

Section: Trophic Effect Of Histamine-2 Agonbtsupporting

confidence: 93%

“…The present study, however, did not show any effect of the H2 agonist impromidine on the stem cell proliferation in the oxyntic mucosa. This is in agreement with a previous study in which gastrin or histamine in equivalent doses with regard to acid secretion was administered to dogs for 4 h (24). Gastrin increased the labelling index, whereas histamine had no effect (24).…”

Section: Trophic Effect Of Histamine-2 Agonbtsupporting

confidence: 93%

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Effect of the Histamine-2 Agonist Impromidine on Stem Cell Proliferation of Rat Oxyntic Mucosa

Brenna

Tielemans²,

Kleveland³

et al. 1995

Scandinavian Journal of Gastroenterology

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Section: Trophic Effect Of Histamine-2 Agonbtsupporting

confidence: 93%

Section: Trophic Effect Of Histamine-2 Agonbtsupporting

confidence: 93%

Effect of the Histamine-2 Agonist Impromidine on Stem Cell Proliferation of Rat Oxyntic Mucosa

Brenna

Tielemans²,

Kleveland³

et al. 1995

Scandinavian Journal of Gastroenterology

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“…A trophic effect of physiological concentrations of gastrin has not been confirmed in gastric antral mucosa [3], pancreas [10], small intestine [7,24], colon [8] or gallbladder [19]. In fact, the only part of the gut that is unanimously recognised as a target for the growthpromoting effect of gastrin is the oxyntic mucosa of the stomach [13,29]. In vivo mitotic activity of both epithelial stem cells and enterochromaffin-like (ECL) cells in this tissue is selectively stimulated by gastrin in experimental animals [12,28].…”

Section: Introductionmentioning

confidence: 99%

Gastrin stimulates epithelial cell proliferation in the oesophagus of rats

Nieuwenhove¹,

Backer

Chen

et al. 1998

Virchows Archiv

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Gastrin can induce mitotic stimulation in the oxyntic mucosa of the stomach, sometimes leading to abnormal growth. We examined whether gastrin was able to influence cell proliferation in the oesophageal epithelium. Rats were treated with gastrin, omeprazole or saline for 3 days, or were subjected to fundectomy or sham operation. Bromodeoxyuridine labelling (LI) and mitotic (MI) indices were counted in the proliferative zone of the squamous epithelium. Infusion of exogenous gastrin, treatment with omeprazole or fundectomy raised the LI and the MI values in the oesophageal epithelium, indicating that gastrin stimulates cell proliferation in the oesophageal mucosa in the rat.

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“…The gastric mucosa is maintained through proliferation of stem cells in the neck region of the glands [58]. Gastrin acts directly [59] on the stem cells or lineage committed precursor cells located in the neck of the glands, whereby the selection for parietal cell fate and proliferation is increased.…”

Section: Neuronal Pathwaymentioning

confidence: 99%

Achlorhydria is associated with gastric microbial overgrowth and development of cancer: Lessons learned from the gastrin knockout mouse

Friis‐Hansen

2006

Scandinavian Journal of Clinical and Laboratory Investigation

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Gastrin and gastrin receptor-deficient mice have been used for genetic dissection of the role of gastrins in maintaining gastric homeostasis and control of acid secretion. The gastrin knockout mice are achlorhydric due to inactivation of the ECL and parietal cells. Moreover, this achlorhydria is associated with intestinal metaplasia and bacterial overgrowth, which ultimately leads to the development of gastric tumours. The association between progastrin, progastrin-derived processing intermediates and colorectal carcinogenesis has also been examined through genetic or chemical cancer induction in several mouse models, although the clinical relevance of these studies remains unproven. While others have focused on models of increased gastrin production, the present review describes the lessons learned from gastrin-deficient mice. Study of these mice helps our understanding of how dysregulation of gastrin secretion may be implicated in human disease.

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Stimulating Effect of Gastrin on Cell Proliferation Kinetics in Canine Fundic Mucosa

Cited by 147 publications

References 17 publications

Effect of the Histamine-2 Agonist Impromidine on Stem Cell Proliferation of Rat Oxyntic Mucosa

Effect of the Histamine-2 Agonist Impromidine on Stem Cell Proliferation of Rat Oxyntic Mucosa

Gastrin stimulates epithelial cell proliferation in the oesophagus of rats

Achlorhydria is associated with gastric microbial overgrowth and development of cancer: Lessons learned from the gastrin knockout mouse

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